Epiandrosterone Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Epiandrosterone interacts with medications. The heart of this page is the interaction list — every drug Epiandrosterone is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Epiandrosterone is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Epiandrosterone against your medication
Add one medicationDrugs that interact with Epiandrosterone
0 medications have a known interaction with Epiandrosterone, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Epiandrosterone. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Epiandrosterone combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Epiandrosterone: Uses, Safety & Side Effects
Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic performance. There is very little high-quality human research showing it works, it can carry hormone-related side effects, and it may cause a positive result on drug tests, so caution is strongly advised.
- Part used
- Synthesized compound (not a plant part)
- Common forms
- Capsules, tablets, powders
- Muscle building and strength
- Bodybuilding 'prohormone' supplement
- Boosting androgen/DHT levels
- Athletic performance
- Fat loss and body recomposition
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
It is a hormone-related supplement with limited safety data and real potential for androgenic side effects.
When used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects inc...
Read the full pregnancy detailWhen used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects inc...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Epiandrosterone is a steroid-related compound that the body naturally makes as a breakdown product (metabolite) of DHEA, which itself comes from the adrenal glands. It is closely linked to testosterone and DHT (dihydrotestosterone) chemistry.
As a supplement, epiandrosterone is made in a lab and sold as a so-called 'prohormone.' It is not an herb or a plant product. It is mostly marketed to bodybuilders and athletes who want to build muscle, gain strength, or improve their physique. You will usually find it as a capsule, tablet, or powder.
How it works
Epiandrosterone is thought to be converted in the body into androgens such as DHT, which is a potent form of testosterone-related hormone. The idea behind the supplement is that boosting these hormones could promote muscle growth, strength, and other 'androgenic' effects.
This proposed mechanism is based mainly on what we know about hormone chemistry and on laboratory reasoning. It is not backed by solid, controlled human research showing how much of the compound is actually converted, or what real-world benefits result. Treat the mechanism as a theory more than a proven fact.
Does Epiandrosterone work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Epiandrosterone, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 7 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Athletic performance
Although there is interest in using oral epiandrosterone for athletic performance, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Although there is interest in using oral epiandrosterone for ED, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Although there is interest in using oral epiandrosterone for muscle recovery after exercise, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Muscle strength
Although there is interest in using oral epiandrosterone for increasing muscle strength, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Obesity
Although there is interest in using oral epiandrosterone for weight loss, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Psychological well-being
Although there is interest in using oral epiandrosterone for improving well-being, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Insufficient Reliable Evidence To Rate Sexual arousal
Although there is interest in using oral epiandrosterone for increasing sexual arousal, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Because epiandrosterone can act on the body's hormone (androgen) pathways, it may carry the same kinds of risks as other prohormone or anabolic-type products. People with hormone-sensitive conditions, prostate problems, liver disease, heart disease, high cholesterol, or a history of hair loss should be especially cautious or avoid it entirely.
Supplements like this are not tightly regulated, so the actual contents and purity can vary between products. Some prohormone products have been found to contain undisclosed ingredients.
Pregnancy and breastfeeding: Avoid it. Hormone-altering substances can be harmful to a developing baby and there is no safety data during breastfeeding.
Athletes: Be aware that epiandrosterone and its metabolites may trigger a positive result on drug or doping tests. Always check with a pharmacist or doctor before using it.
Side effects
Reported and expected side effects relate to its androgenic (male-hormone) activity and may include acne, oily skin, hair loss or scalp thinning, increased body or facial hair, mood changes, and irritability.
Like other prohormone products, there are concerns about possible effects on cholesterol, the liver, the prostate, and the body's own natural hormone production. In women, androgenic supplements can cause unwanted masculinizing effects. Serious effects are not well studied, which is itself a reason for caution.
Stop using it and seek medical care if you notice signs of liver trouble (such as yellowing skin or eyes, dark urine, or severe abdominal pain) or any other concerning symptoms.
Dosing
There is no established, medically recommended dose for epiandrosterone. It has not been studied well enough to define a safe and effective amount.
If a product is used, follow the directions on the label and do not exceed them. Because this is a hormone-related supplement with real potential risks, talk with a pharmacist or doctor before starting, and avoid combining it with other prohormone or hormone products.
Epiandrosterone & Pregnancy
Epiandrosterone & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Epiandrosterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Epiandrosterone
24 brands in our database make a supplement containing Epiandrosterone.
Supplement products with Epiandrosterone
37 products in our database contain Epiandrosterone. Open any to see its full ingredient list and every drug interaction we check.
Epiandrosterone: Common Questions
What is Epiandrosterone used for, and does it work?
Does Epiandrosterone interact with prescription medications?
How are Epiandrosterone interactions rated?
Is it safe to take Epiandrosterone with my medications?
Where does this Epiandrosterone interaction information come from?
What is Epiandrosterone used for?
Is Epiandrosterone a steroid?
Is Epiandrosterone safe?
Can it cause a failed drug test?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Epiandrosterone
A rotating sample of real supplements in our database that list Epiandrosterone — open any to see its full ingredients and every drug interaction we check.
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