Herb & supplement monograph

Mullein Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Mullein interacts with medications. The heart of this page is the interaction list — every drug Mullein is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Mullein is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Mullein

122 medications have a known interaction with Mullein, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Abciximab interaction
AbrocitinibCibinqo
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcenocoumarolSintrom
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, IbuprofenCombogesic
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Acetaminophen, Ibuprofen interaction
Acetylsalicylic AcidEntrophen
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Acetylsalicylic Acid interaction Acetylsalicylic Acid drug page: uses, dosage & side effects
Alteplase, TpaActilyse, Activase
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Alteplase, Tpa interaction
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction
Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction Aluminum Hydroxide, Aspirin, Magnesium Hydroxide drug page: uses, dosage & side effects
Anacaulase-bcdbNexoBrid
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Anacaulase-bcdb interaction
AnagrelideAgrylin
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Anagrelide interaction Anagrelide drug page: uses, dosage & side effects
AnisindioneMiradon
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Anisindione interaction
Antithrombin IiiThrombate III
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Antithrombin Iii interaction
ApixabanEliquis
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Apixaban interaction Apixaban drug page: uses, dosage & side effects
ArgatrobanArgatroban
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Argatroban interaction
AspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin interaction Aspirin drug page: uses, dosage & side effects
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interaction
Aspirin, ButalbitalAxotal
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Butalbital interaction
Aspirin, Butalbital, CaffeineFiorinal
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Butalbital, Caffeine interaction Aspirin, Butalbital, Caffeine drug page: uses, dosage & side effects
Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction
Aspirin, Butalbital, Caffeine, PhenacetinMarnal
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Butalbital, Caffeine, Phenacetin interaction
Aspirin, CaffeineAnacin
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine interaction
Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Codeine Phosphate interaction
Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction
Aspirin, Caffeine, Dover's PwdAcedoval, Dovacet
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Dover's Pwd interaction
Aspirin, Caffeine, HydrocodoneDamason-P
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Hydrocodone interaction
Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin drug page: uses, dosage & side effects
Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Orphenadrine interaction
Aspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
Minor Anticoagulant/antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.

Read the full Mullein + Aspirin, Caffeine, Phenacetin, Propoxyphene interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Mullein combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Mullein affects

Every type of medication (drug category) Mullein is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Mullein interacts with
Anticoagulant/antiplatelet Drugs
Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Monograph

Mullein: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits are not well proven, but it is generally considered low-risk for short-term use in healthy adults. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a medical condition.

Mullein
Scientific name
Verbascum thapsus
Family
Scrophulariaceae
Part used
Leaves and flowers (sometimes roots)
Common forms
Tea (infusion), tincture, capsules, syrups, lozenges, and ear oil drops
People commonly use it for
  • Cough and chest congestion
  • Sore throat
  • Bronchitis and respiratory irritation
  • Earache (traditional ear oil)
  • Mild inflammation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated for short-term use, but human safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Mullein is a tall flowering plant with soft, fuzzy leaves and a long stalk of yellow flowers that can grow up to about 2 meters high. It grows wild across many temperate and mountain regions of Europe, Asia, and North America, often in dry, sunny areas along roadsides and fields.

People have used mullein in folk medicine for hundreds of years, mainly for breathing and throat problems. The leaves and flowers are the parts most often used. They are commonly brewed into a tea, made into syrups or tinctures, or infused into oil that is dropped into the ear for earaches.

How it works

Mullein contains several plant compounds that may explain its traditional uses. These include mucilage (a slippery, gel-like substance), saponins, flavonoids, and iridoid glycosides such as aucubin.

The mucilage is thought to coat and soothe irritated tissues in the throat and airways, which is why mullein is used for coughs and sore throats. The flavonoids and other compounds have shown possible anti-inflammatory and antimicrobial activity in laboratory studies. Keep in mind these mechanisms are mostly based on test-tube and animal research, and they have not been clearly confirmed in well-designed human trials.

Effectiveness

Does Mullein work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 10 uses evaluated
10 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Mullein, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 10 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for asthma, there is insufficient reliable information about the clinical effects of mullein for this condition.

Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for bronchitis, there is insufficient reliable information about the clinical effects of mullein for this condition.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for cough, there is insufficient reliable information about the clinical effects of mullein for this purpose.

Insufficient Reliable Evidence To Rate Diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for diarrhea, there is insufficient reliable information about the clinical effects of mullein for this purpose.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical mullein for hemorrhoids, there is insufficient reliable information about the clinical effects of mullein for this purpose.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for influenza, there is insufficient reliable information about the clinical effects of mullein for this condition.

Insufficient Reliable Evidence To Rate Migraine headache
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for migraine headache, there is insufficient reliable information about the clinical effects of mullein for this condition.

Insufficient Reliable Evidence To Rate Otitis media
Rating & evidence shown verbatim from Natural Medicines

Topical mullein has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Pneumonia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral mullein for pneumonia, there is insufficient reliable information about the clinical effects of mullein for this condition.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical mullein is helpful for healing episiotomy wounds.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Mullein is generally considered low-risk for short-term use in healthy adults when taken as a tea or labeled supplement. Still, because human safety studies are limited, it should be used with care.

The tiny hairs on mullein leaves can irritate the throat or skin in some people, so teas are usually strained well. People with allergies to plants in the same family may be more likely to react. Do not put any liquid, including mullein ear oil, into the ear if you have or suspect a ruptured eardrum, or if there is drainage or severe pain — see a healthcare provider instead.

For pregnancy and breastfeeding, there is not enough reliable safety information, so the safest choice is to avoid mullein. Children, older adults, and people with chronic health conditions should check with a pharmacist or doctor before using it.

Side effects

Mullein is usually well tolerated. Reported side effects are generally mild and may include throat or skin irritation (often from the plant's tiny hairs) and occasional stomach upset.

Allergic reactions are possible but uncommon. Stop using mullein and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing. Because the seeds of the plant can be toxic, only use products made from the leaves and flowers from a reputable source.

Mullein: Reported Adverse Effects

Documented safety reports on Mullein from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Dermatitis Dermatologic

Two case reports have described dermatitis, with positive patch tests, after topical exposure to the whole plant, or by occupational inhalation of plant dust. In the case of topical exposure, the patient also had positive patch tests to other plants.

  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for mullein. The amount used varies widely between products and traditional recipes, such as teas, tinctures, capsules, and syrups.

The safest approach is to follow the directions on the product label and not exceed the recommended amount. If you are unsure how much to take or whether mullein is appropriate for you, ask a pharmacist or doctor. A well-made tea is typically prepared by steeping the dried leaves or flowers in hot water and straining well to remove the irritating plant hairs.

Pregnancy & Breastfeeding

Mullein & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Mullein & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Mullein monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Mullein

144 brands in our database make a supplement containing Mullein.

Product directory

Supplement products with Mullein

783 products in our database contain Mullein. Open any to see its full ingredient list and every drug interaction we check.

Echinacea Immune Support by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 0.85 Oz(s) · 24 Gram(s) Off market View ingredients & interactions Echinamide Active Defense Honey Lemon Syrup by Natural Factors Liquid 5 fl. Oz. · 150 mL Off market View ingredients & interactions Elderberry Syrup Defense Formula by Quantum Health Liquid 4 fl. Oz. · 120 mL Off market View ingredients & interactions Elderberry with Vitamin C & Echinacea by Windmill Natural Vitamins Other (e.g. Tea Bag) 60 Wafer(s) Off market View ingredients & interactions Elderberry+ by Quantum Health Liquid 4 fl. Oz. · 118 mL Off market View ingredients & interactions Elderberry+ Great Raspberry Flavor 200 mg by Quantum Health Lozenge 36 Lozenge(s) Off market View ingredients & interactions Elderberry+ Lozenges Raspberry Flavor 200 mg by Quantum Health Lozenge 36 Lozenge(s) Off market View ingredients & interactions Fenugreek Seed Complex by MNP Michael's Naturopathic Programs Tablet Or Pill 60 Vegetarian Tablet(s) Off market View ingredients & interactions Fenugreek Seed Complex by MNP Michael's Naturopathic Programs Tablet Or Pill 60 Vegetarian Tablet(s) Off market View ingredients & interactions Fenugreek Seed Complex by MNP Michael's Naturopathic Programs Tablet Or Pill 60 Vegetarian Tablet(s) Off market View ingredients & interactions First Cleanse 1 Morning Formula by Renew Life Capsule 30 Vegetable Capsule(s) Off market View ingredients & interactions First Cleanse 1 Morning Formula by Renew Life Capsule 30 Capsule(s) Off market View ingredients & interactions First Cleanse 1 Morning Formula by Renew Life Capsule 30 Capsule(s) Off market View ingredients & interactions FirstDetox I Morning Formula by Advanced Naturals Capsule 30 Vegetable Capsule(s) Off market View ingredients & interactions Formula 17 Immune Support by NESS Nutritional Enzyme Support System Capsule 90 Capsule(s) Off market View ingredients & interactions Formula 17 Immune Support by NESS Nutritional Enzyme Support System Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions Formula 301 Sinus Support by NESS Nutritional Enzyme Support System Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions Formula 301 Sinus Support by NESS Nutritional Enzyme Support System Capsule 90 Capsule(s) Off market View ingredients & interactions Four by Nature's Sunshine Capsule 100 Capsule(s) Off market View ingredients & interactions Full Spectrum Mullein Leaf 500 mg by Swanson Premium Brand Capsule 60 Capsule(s) Off market View ingredients & interactions HCP-X by Nature's Sunshine Capsule 100 Capsule(s) Off market View ingredients & interactions Herbal Iron by New Sun Capsule 100 Capsule(s) Off market View ingredients & interactions Herbal Lung Formula by Indiana Botanic Gardens Capsule 30 Capsule(s) Off market View ingredients & interactions Herbal Lung Formula by Indiana Botanic Gardens Capsule 30 Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Mullein: Common Questions

What is Mullein used for, and does it work?
People use Mullein for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Mullein interact with prescription medications?
Yes. We list 122 medications with a known interaction with Mullein. Use the checker above to see how Mullein interacts with a specific drug.
How are Mullein interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Mullein with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Mullein interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Mullein commonly used for?
It is most often used as a tea or syrup to soothe coughs, sore throats, and chest congestion, and traditionally as an ear oil for earaches. These are traditional uses and are not strongly proven by clinical research.
Is Mullein safe to take?
For most healthy adults, short-term use of Mullein tea or labeled supplements is generally considered low-risk. Because human safety data are limited, it is best to check with a pharmacist or doctor, especially if you have a health condition.
Can I use Mullein while pregnant or breastfeeding?
There is not enough reliable safety information, so the safest choice is to avoid Mullein during pregnancy and breastfeeding unless your doctor advises otherwise.
Does Mullein actually cure coughs or ear infections?
There is no strong human evidence that Mullein cures these conditions. It may help soothe irritation, but it should not replace proper medical care for infections or ongoing symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Mullein

A rotating sample of real supplements in our database that list Mullein — open any to see its full ingredients and every drug interaction we check.

See all 783 products with Mullein →
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