Medication interaction hub

What Supplements Interact with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Acetaminophen, Brompheniramine, Phenylpropanolamine brand name: Dimetapp Cold and Flu. Every interaction below applies to the brands too.

216 Interactions 9 Major 168 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Brompheniramine, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Brompheniramine, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

This combination cold medicine deserves real care around supplements, mainly because of the decongestant it contains. Phenylpropanolamine, one of the three ingredients in Dimetapp Cold and Flu (alongside acetaminophen and brompheniramine), is a stimulant, and the most serious entries here are herbs like ephedra that push heart rate and blood pressure in the same direction. The other major concern is alcohol, since regular or heavy drinking raises the liver risk that already comes with acetaminophen.

Beyond those, the pattern is milder but wide. Everyday caffeine sources such as coffee, tea, and cocoa can amplify the jittery, wired feeling, a cluster of herbs adds sun sensitivity, and a few things (activated charcoal especially) can blunt how much of the medicine your body absorbs, so space doses well apart. Of the 216 ingredients on file, 9 rate major, 168 moderate, and 39 minor.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 168 Minor 39 No known interaction 1,236

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Brompheniramine, Phenylpropanolamine: Top Interactions at a Glance

The Acetaminophen, Brompheniramine, Phenylpropanolamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 216 interacting ingredients — plus 1,236 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Brompheniramine, Phenylpropanolamine Combinations Today

The Acetaminophen, Brompheniramine, Phenylpropanolamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Probable Vitamin C + Acetaminophen, Brompheniramine, Phenylpropanolaminei

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Brompheniramine, Phenylpropanolaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Minor Likelihood Possible Beet + Acetaminophen, Brompheniramine, Phenylpropanolaminei

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Brompheniramine, Phenylpropanolaminei

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction Minor Likelihood Possible Black Pepper + Acetaminophen, Brompheniramine, Phenylpropanolaminei

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Bilberry + Acetaminophen, Brompheniramine, Phenylpropanolaminei

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Brompheniramine, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 216 with a Acetaminophen, Brompheniramine, Phenylpropanolamine interaction on file and 1,236 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Brompheniramine, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Caffeine with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Beet with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Ashwagandha with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Black Pepper with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Full Black Pepper + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Testolone with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Thuja with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Thunder God Vine with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Tinospora Cordifolia with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.

Full Tinospora Cordifolia + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Tragacanth with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Turmeric with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Uva Ursi with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Valerian with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Vitamin A with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Wheatgrass with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Winter Cherry with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).

Full Winter Cherry + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Yohimbe with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with stimulant drugs can have additive effects.

Full Yohimbe + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Zizyphus with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Thyroid Extract with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine answer

Can you take Hibiscus Sabdariffa with Acetaminophen, Brompheniramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.

Full Hibiscus Sabdariffa + Acetaminophen, Brompheniramine, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Brompheniramine, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Brompheniramine, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Brompheniramine, Phenylpropanolamine sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Brompheniramine, Phenylpropanolamine through this category.

Related: does Acetaminophen, Brompheniramine, Phenylpropanolamine deplete any nutrients?

Acetaminophen, Brompheniramine, Phenylpropanolamine has 1 reported nutrient association in the research literature — see the Acetaminophen, Brompheniramine, Phenylpropanolamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Brompheniramine, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Brompheniramine, Phenylpropanolamine.

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Pharmacist Counseling Corner

Acetaminophen, Brompheniramine, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Acetaminophen, Brompheniramine, Phenylpropanolamine?
Our database currently documents 216 ingredients with a known Acetaminophen, Brompheniramine, Phenylpropanolamine interaction (9 major, 168 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 216. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Acetaminophen, Brompheniramine, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Ephedra and Peyote, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Brompheniramine, Phenylpropanolamine?
Plenty of supplements coexist fine with Acetaminophen, Brompheniramine, Phenylpropanolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Dimetapp Cold and Flu have the same supplement interactions as Acetaminophen, Brompheniramine, Phenylpropanolamine?
Yes — Dimetapp Cold and Flu all contain Acetaminophen, Brompheniramine, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Brompheniramine, Phenylpropanolamine deplete any vitamins or nutrients?
It might — Acetaminophen, Brompheniramine, Phenylpropanolamine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Brompheniramine, Phenylpropanolamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Brompheniramine, Phenylpropanolamine and my other medications?
This page covers Acetaminophen, Brompheniramine, Phenylpropanolamine against supplements and herbal ingredients. Checking Acetaminophen, Brompheniramine, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.