Cannabidiol (cbd) + Acetaminophen, Brompheniramine, Phenylpropanolamine
Acetaminophen, Brompheniramine, Phenylpropanolamine brand name: Dimetapp Cold and Flu.
Acetaminophen, Brompheniramine, Phenylpropanolamine falls into 3 drug categories that Cannabidiol (cbd) can interact with; the most serious is rated moderate. Cannabidiol may increase levels of drugs metabolized by CYP1A2.
Read the full interaction reportCannabidiol (cbd) and Acetaminophen, Brompheniramine, Phenylpropanolamine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Cannabidiol (cbd) interacts with whole categories of medication. Acetaminophen, Brompheniramine, Phenylpropanolamine falls into 3 of those categories, so it can interact with Cannabidiol (cbd) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Brompheniramine, Phenylpropanolamine
Acetaminophen, Brompheniramine, Phenylpropanolamine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Cannabidiol (cbd) interacts with.
In vitro research shows that cannabidiol inhibits CYP1A2. Furthermore, clinical studies show that cannabidiol may inhibit the metabolism of caffeine, a CYP1A2 substrate. Two pharmacokinetic studies in healthy adults show that taking cannabidiol dosed 640 mg once up to 750 twice daily increases the area under the curve of caffeine. However, results are mixed over whether cannabidiol impacts peak serum levels of caffeine.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
This Dimetapp Cold and Flu combo packs three ingredients, but the one tied to this interaction is acetaminophen, which the liver partly clears using an enzyme called CYP1A2. Since CBD can slow that enzyme down, your body may break acetaminophen down a little more slowly, which could nudge its levels up.
For most people taking a normal dose, this is a minor concern. The bigger thing to watch is total acetaminophen, since it's hard on the liver in large amounts. None of these are prodrugs, so CBD wouldn't make them work harder, just linger a bit longer. The brompheniramine (a sedating antihistamine) plus CBD could also add to drowsiness. Check with your pharmacist before combining them, especially if you use CBD daily.
- Yamaori S, Kushihara M, Yamamoto I, Watanabe K. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective potent inhibitors of human CYP1 enzymes. Biochem Pharmacol 2010;79(11):1691-8.
- Thai C, Tayo B, Critchley D. A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects. Clin Pharmacol Drug Dev. 2021. PubMed
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
- Bansal S, Zamarripa CA, Spindle TR, et al. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clin Pharmacol Ther 2023.
GLUCURONIDATED DRUGS
2 of 3Acetaminophen, Brompheniramine, Phenylpropanolamine also falls under GLUCURONIDATED DRUGS.
In vitro research shows that cannabidiol inhibits uridine diphosphoglucuronosyl transferase (UGT) 1A9 and UGT2B7, enzymes responsible for glucuronidation. Theoretically, this could decrease the clearance and increase levels of glucuronidated drugs.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Dimetapp Cold and Flu, which mixes acetaminophen (Tylenol), brompheniramine (an antihistamine), and phenylpropanolamine (a decongestant). One way your body clears acetaminophen is through enzymes called UGTs. In lab dishes, CBD slows those same enzymes down. The theory is that acetaminophen could hang around a little longer and build up slightly.
I want to be honest about how soft this evidence is. It comes only from test-tube studies, not from real people, so we don't know if it matters in everyday life. If anything, you might feel a bit more drowsy or notice more acetaminophen in your system, but that's not proven. The bigger real-world tip: don't double up on Tylenol from other products. Run your CBD plan past your pharmacist first.
- Epidiolex (cannabidiol) prescribing information. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Available at: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (accessed 5/9/2019)
CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES
3 of 3Acetaminophen, Brompheniramine, Phenylpropanolamine also falls under CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES.
In vitro research shows that cannabidiol inhibits CYP2E1. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece that matters with this combo product: the acetaminophen in your Dimetapp is partly handled by a liver enzyme called CYP2E1. In lab studies (test tube, not people), CBD appears to slow that enzyme down. In theory, slowing it could let a bit more acetaminophen linger in your system. The good news is that this has never actually been reported in humans, so it stays in the 'possible on paper' category for now.
Why I still mention it: acetaminophen is hard on the liver in high amounts. If you take this cold medicine regularly, layer on other Tylenol-containing products, or drink alcohol, that's where I'd be more careful. The brompheniramine and phenylpropanolamine parts aren't the concern here. Before pairing CBD with this product, check in with your pharmacist or doctor so you can keep your total acetaminophen in a safe range.
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cannabidiol (cbd) Also Interacts With Other Medications
Cannabidiol (cbd) has 1,050 moderate known drug interactions in our database — the Acetaminophen, Brompheniramine, Phenylpropanolamine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cannabidiol (cbd)
We haven’t checked that one against Cannabidiol (cbd) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cannabidiol (cbd). Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Brompheniramine, Phenylpropanolamine
This page covers Cannabidiol (cbd) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Brompheniramine, Phenylpropanolamine page lists 216 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Peyote (major).
By severity: 9 major · 168 moderate · 39 minor.
From our pharmacist’s overview on the Acetaminophen, Brompheniramine, Phenylpropanolamine page
“This combination cold medicine deserves real care around supplements, mainly because of the decongestant it contains. Phenylpropanolamine, one of the three ingredients in Dimetapp Cold and Flu (alongside acetaminophen and brompheniramine), is a stimulant, and the most serious entries here are herbs like ephedra that push heart rate and…”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Brompheniramine, Phenylpropanolamine interaction page
Where Cannabidiol (cbd) and Acetaminophen, Brompheniramine, Phenylpropanolamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#523 of 1,452 supplements looked up here in the last 7 days
#85 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cannabidiol (cbd)
What is Cannabidiol (cbd)?
- Anxiety and stress
- Sleep problems
- Chronic pain
- Certain seizure disorders
- Inflammation
CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorders (as a prescription drug), while most other popular uses are still backed by limited or early research. Product quality varies a lot, so talk with your pharmacist or doctor before using it, especially if you take other medicines.
Other Drugs & Cannabidiol (cbd)
Browse every other medication we’ve checked against Cannabidiol (cbd) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,050 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Orphenadrine ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Griseofulvin ›
- Ivabradine ›
Showing 60 of 1,050 moderate interactions — see all 1,050 on the Cannabidiol (cbd) page.
No interaction 1,779 drugs checked — show the list
We also checked Cannabidiol (cbd) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Aspirin ›
- Rosuvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Methotrexate ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Levothyroxine, Liothyronine ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Cephalexin ›
- Cyclopentolate ›
- Acetylsalicylic Acid ›
- Ezetimibe ›
- Mannitol ›
- Carbidopa, Levodopa ›
- Thyroid Hormone ›
- Spironolactone ›
- Levodopa ›
- Dexmethylphenidate ›
- Levothyroxine Sodium ›
- Pizotifen ›
- Daptomycin ›
- Lenvatinib ›
- Canagliflozin, Metformin ›
- Flutemetamol F-18 ›
- Hexobarbitone ›
- Cefaclor ›
- Mitomycin ›
- Insulin Degludec, Liraglutide ›
- Magnesium Hydroxide (otc Drug) ›
- Hydroxychloroquine ›
- Pegunigalsidase Alfa-iwxj ›
- Minoxidil ›
- Casanthranol, Docusate ›
- Atenolol ›
- Hethylphenidate Hcl ›
- Factor 7a ›
- Salbutamol Sulfate ›
- Hydrochlorothiazide ›
- Insulin Human, Sodium Chloride ›
- Alginic Acid, Aluminum Hydroxide ›
- Alglucosidase Alpha ›
- Bentoquatam ›
- Azelaic Acid ›
- Vancomycin ›
- Tocainide ›
- Phenylephrine ›
Showing the 60 most looked-up of 1,779 medications checked with no known interaction — see the full Cannabidiol (cbd) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Brompheniramine, Phenylpropanolamine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Brompheniramine, Phenylpropanolamine as a medicine that can lower these. This is not an interaction with Cannabidiol (cbd) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Brompheniramine, Phenylpropanolamine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cannabidiol (cbd) and Acetaminophen, Brompheniramine, Phenylpropanolamine Together: Common Questions
Can you take Cannabidiol (cbd) with Acetaminophen, Brompheniramine, Phenylpropanolamine?
Why are there 3 interactions listed for Cannabidiol (cbd) and Acetaminophen, Brompheniramine, Phenylpropanolamine?
How serious is the Cannabidiol (cbd) and Acetaminophen, Brompheniramine, Phenylpropanolamine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.