Medication interaction hub

What Supplements Interact with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide brand name: Bufferin. Every interaction below applies to the brands too.

253 Interactions 7 Major 208 Moderate 38 Minor

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bufferin pairs aspirin with calcium and magnesium antacids, and its interaction list earns genuine caution, not panic. The dominant concern is bleeding: 202 of the 253 supplements and herbs on file can add to aspirin's blood-thinning effect, raising the chance of bruising or gastrointestinal bleeds. Beer and wine sit among the seven major-rated entries, since alcohol taken with aspirin raises the risk of stomach bleeding, and that pairing happens without much thought.

A smaller set works differently. A few herbs, Siberian cocklebur among them, can strain the kidneys on top of aspirin, while activated charcoal and viscous fibers can blunt absorption of anything swallowed, so keep those well apart from a dose. The antacid components can also cut absorption of certain minerals. The 208 moderate and 38 minor entries carry less urgency, but the seven majors, alcohol included, are worth understanding before opening a supplement bottle.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide: Top Interactions at a Glance

The most significant Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 253 interacting ingredients — plus 1,199 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide + supplement combinations in our database, best-documented first. Open any card for the full report.

The complete list

Every Supplement Checked Against Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide

All 1,452 ingredients in our database, ranked by severity — 253 with a Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interaction on file and 1,199 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Straight answers

Can You Take It With Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Thyme with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.

Full Thyme + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Tianeptine with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Chronic use of aspirin might increase the levels and clinical effects of tianeptine.

Full Tianeptine + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Tiratricol with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might increase the hypoprothrombinemic effects of oral anticoagulants.

Full Tiratricol + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Tragacanth with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Tree Of Heaven with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or antic...

Full Tree Of Heaven + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Tree Turmeric with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleedi...

Full Tree Turmeric + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Turmeric with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Turmeric + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Vanadium with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Vanadium + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Vinpocetine with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vinpocetine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Vinpocetine + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Vitamin E with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Wasabi with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Wasabi + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take White Pepper with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits platelet aggregation.

Full White Pepper + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Yerba Mate with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Yerba Mate + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Arnica with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Blue-green Algae with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.

Full Blue-green Algae + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Chinese Prickly Ash with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Chinese prickly ash might inhibit platelet aggregation.

Full Chinese Prickly Ash + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Coffee with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Coffee + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Cola Nut with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cola Nut + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Docosahexaenoic Acid (dha) with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Docosahexaenoic Acid (dha) + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer

Can you take Fenugreek with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.

Full Fenugreek + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide sits in 8 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Antacids 13 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

13 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide through this category.

About Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide

Aspirin is a pain reliever and anti-inflammatory medication used to treat pain, fever, arthritis, and help prevent heart attacks and strokes.

Generic name: Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide  ·  Brand name: Bufferin.

See the full Aspirin drug information

Related: does Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide deplete any nutrients?

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide has 8 reported nutrient associations in the research literature — see the Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide.

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Pharmacist Counseling Corner

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide & Supplements: Common Questions

What supplements interact with Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?
More than you might expect — 253 in total, though they are far from equal: 7 are rated major, 208 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide supplement interactions are the most serious?
The 7 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?
Usually yes — most people on Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Bufferin have the same supplement interactions as Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide?
Yes — Bufferin all contain Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide deplete any vitamins or nutrients?
It might — Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide and my other medications?
This page covers Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide against supplements and herbal ingredients. Checking Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Aspirin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 3, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.