Medication interaction hub

What Supplements Interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Chlorpheniramine, Phenylephrine, Phenylpropanolamine brand name: Rutuss. Every interaction below applies to the brands too.

229 Interactions 10 Major 175 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine, Phenylephrine, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rutuss combines an antihistamine, chlorpheniramine, with two decongestants, phenylephrine and phenylpropanolamine, and its supplement interactions call for real care. Ten of the 229 ingredients on file carry a major rating. Because the decongestants are stimulants, herbs with stimulant effects, ephedra above all, can push blood pressure and heart rate into dangerous territory. Grapefruit can raise the drug's levels by blocking the enzyme that clears it, while St. John's wort does the opposite and can weaken it.

Most of the rest, 175 moderate and 44 minor entries, repeats those themes at lower intensity. Everyday caffeine sources add stimulant load, drying and sedating botanicals stack onto the antihistamine, and a smaller set raises sun sensitivity or touches serotonin. If an herbal stimulant is part of your day, even something as ordinary as strong tea, that pairing is the one to sort out with a pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 175 Minor 44 No known interaction 1,223

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorpheniramine, Phenylephrine, Phenylpropanolamine: Top Interactions at a Glance

The Chlorpheniramine, Phenylephrine, Phenylpropanolamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorpheniramine, Phenylephrine, Phenylpropanolamine Combinations Today

The Chlorpheniramine, Phenylephrine, Phenylpropanolamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Coffee + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Cranberry + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible American Elder + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Marshmallow + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Uva Ursi + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Garlic + Chlorpheniramine, Phenylephrine, Phenylpropanolaminei

Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine, Phenylephrine, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 229 with a Chlorpheniramine, Phenylephrine, Phenylpropanolamine interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Cranberry with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take American Elder with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Marshmallow with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Uva Ursi with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Purple Nut Sedge with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Quercetin with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Rabdosia Rubescens with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Raspberry Ketone with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Rauwolscine with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Resveratrol with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Rooibos with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Rue with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Sage with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Same with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.

Full Same + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Schizonepeta with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Securinega Suffruticosa with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Slippery Elm with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Sulforaphane with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer

Can you take Sweet Annie with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Chlorpheniramine, Phenylephrine, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine, Phenylephrine, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine, Phenylephrine, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine, Phenylephrine, Phenylpropanolamine sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine, Phenylephrine, Phenylpropanolamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine, Phenylephrine, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine, Phenylephrine, Phenylpropanolamine.

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Pharmacist Counseling Corner

Chlorpheniramine, Phenylephrine, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine?
Our database currently documents 229 ingredients with a known Chlorpheniramine, Phenylephrine, Phenylpropanolamine interaction (10 major, 175 moderate, 44 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 229. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Chlorpheniramine, Phenylephrine, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Ephedra, Henbane and Lithium, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine, Phenylephrine, Phenylpropanolamine?
Plenty of supplements coexist fine with Chlorpheniramine, Phenylephrine, Phenylpropanolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Rutuss have the same supplement interactions as Chlorpheniramine, Phenylephrine, Phenylpropanolamine?
Yes — Rutuss all contain Chlorpheniramine, Phenylephrine, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine, Phenylephrine, Phenylpropanolamine and my other medications?
This page covers Chlorpheniramine, Phenylephrine, Phenylpropanolamine against supplements and herbal ingredients. Checking Chlorpheniramine, Phenylephrine, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.