Marjoram - Chlorpheniramine, Phenylephrine, Phenylpropanolamine Interaction
Herbal: Marjoram
Also Known As: Origanum majorana, Essence de Marjolaine, Garden Marjoram, Gartenmajoran, Huile de Marjolaine, Knotted Marjoram, Maggiorana, Majoran, Majorana Aetheroleum Oil, Majorana Herb, Manjerona, Mardkouch, Marjolaine, Marjolaine des Jardins, Marjolaine Ordinaire
Drug: Chlorpheniramine, Phenylephrine, Phenylpropanolamine
Brand names:
Rutuss
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Chlorpheniramine, Phenylephrine, Phenylpropanolamine is classified as belonging to the following category: Anticholinergic Drugs
In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity. Theoretically, using marjoram in medicinal amounts along with anticholinergic drugs might decrease the effectiveness of marjoram or the anticholinergic agent.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
- Chung, Y. K., Heo, H. J., Kim, E. K., Kim, H. K., Huh, T. L., Lim, Y., Kim, S. K., and Shin, D. H. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol.Cells 4-30-2001;11(2):137-143.
Marjoram Overview
Marjoram is an herb native to the Mediterranean region and is related to oregano. It is often utilized in several ways, including as food and in commercial products, such as soaps.
Marjoram is a good source of antioxidants and is purported to have a variety of potential health benefits. It has been used in traditional medicine to several conditions, including respiratory problems, insomnia, and digestive disorders. It is also sometimes used in aromatherapy to promote relaxation and stress relief.
Marjoram - More Interactions
Marjoram interacts with 334 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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