Medication interaction hub

What Supplements Interact with Dorzolamide Hydrochloride, Timolol Maleate?

Dorzolamide Hydrochloride, Timolol Maleate brand name: Cosopt PF. Every interaction below applies to the brands too.

71 Interactions 1 Major 59 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dorzolamide Hydrochloride, Timolol Maleate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dorzolamide Hydrochloride, Timolol Maleate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The one major-rated interaction with Cosopt PF (dorzolamide and timolol eye drops for glaucoma) belongs to Indian snakeroot, and it is the entry to understand first. Timolol is a beta-blocker that reaches the bloodstream even from an eye drop, and Indian snakeroot may deepen that effect enough to slow the heart or drop blood pressure too far. With 71 interacting ingredients on file, this page rewards a careful read rather than a skim.

Most of the list, 60 ingredients including goldenseal and CBD, can slow how the body clears timolol, letting the drug and its side effects build. Beyond that single major entry, 59 are rated moderate and 11 minor. A few, policosanol among them, add directly to timolol's pressure-lowering action, and six may lower the seizure threshold, worth knowing if seizures are already part of your medical history.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 59 Minor 11 No known interaction 1,381

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dorzolamide Hydrochloride, Timolol Maleate: Top Interactions at a Glance

The most significant Dorzolamide Hydrochloride, Timolol Maleate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 71 interacting ingredients — plus 1,381 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dorzolamide Hydrochloride, Timolol Maleate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Indian Snakeroot + Dorzolamide Hydrochloride, Timolol Maleatei

Theoretically, taking Indian snakeroot with beta-blockers might increase the risk of bradycardia and/or hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Dorzolamide Hydrochloride, Timolol Maleate

All 1,452 ingredients in our database, ranked by severity — 71 with a Dorzolamide Hydrochloride, Timolol Maleate interaction on file and 1,381 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dorzolamide Hydrochloride, Timolol Maleate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hibiscus Sabdariffa with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2D6 substrates.

Full Hibiscus Sabdariffa + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Hordenine with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full Hordenine + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Puravive with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Eleuthero with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Humann Superbeets Heart Chews with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Kava with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Valerian with Dorzolamide Hydrochloride, Timolol Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Full Valerian + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Indian Snakeroot with Dorzolamide Hydrochloride, Timolol Maleate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking Indian snakeroot with beta-blockers might increase the risk of bradycardia and/or hypotension.

Full Indian Snakeroot + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Ayahuasca with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.

Full Ayahuasca + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Goldenseal with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Octacosanol with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.

Full Octacosanol + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Policosanol with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.

Full Policosanol + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Syrian Rue with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Syrian Rue + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take 1,3-dmaa with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Acacia Rigidula with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 su...

Full Acacia Rigidula + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Active Hexose Correlated Compound (ahcc) with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Berberine with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.

Full Berberine + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Beta-methylphenethylamine (bmpea) with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.

Full Beta-methylphenethylamine (bmpea) + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Biofeedback with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Dorzolamide Hydrochloride, Timolol Maleate answer

Can you take Black Cohosh with Dorzolamide Hydrochloride, Timolol Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.

Full Black Cohosh + Dorzolamide Hydrochloride, Timolol Maleate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dorzolamide Hydrochloride, Timolol Maleate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dorzolamide Hydrochloride, Timolol Maleate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dorzolamide Hydrochloride, Timolol Maleate sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Dorzolamide Hydrochloride, Timolol Maleate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Dorzolamide Hydrochloride, Timolol Maleate through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Dorzolamide Hydrochloride, Timolol Maleate through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dorzolamide Hydrochloride, Timolol Maleate through this category.

Related: does Dorzolamide Hydrochloride, Timolol Maleate deplete any nutrients?

Dorzolamide Hydrochloride, Timolol Maleate has 1 reported nutrient association in the research literature — see the Dorzolamide Hydrochloride, Timolol Maleate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dorzolamide Hydrochloride, Timolol Maleate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dorzolamide Hydrochloride, Timolol Maleate.

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Pharmacist Counseling Corner

Dorzolamide Hydrochloride, Timolol Maleate & Supplements: Common Questions

What supplements interact with Dorzolamide Hydrochloride, Timolol Maleate?
In our interaction database, 71 supplement and herbal ingredients have an interaction with Dorzolamide Hydrochloride, Timolol Maleate on file — 1 rated major, 59 moderate, and 11 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Indian Snakeroot, Ayahuasca, Goldenseal.
Which Dorzolamide Hydrochloride, Timolol Maleate supplement interactions are the most serious?
Focus on the major group: Indian Snakeroot. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Dorzolamide Hydrochloride, Timolol Maleate?
That depends entirely on which supplement. The honest answer for Dorzolamide Hydrochloride, Timolol Maleate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Cosopt PF have the same supplement interactions as Dorzolamide Hydrochloride, Timolol Maleate?
Yes — Cosopt PF all contain Dorzolamide Hydrochloride, Timolol Maleate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Dorzolamide Hydrochloride, Timolol Maleate deplete any vitamins or nutrients?
It might — Dorzolamide Hydrochloride, Timolol Maleate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Dorzolamide Hydrochloride, Timolol Maleate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Dorzolamide Hydrochloride, Timolol Maleate and my other medications?
This page covers Dorzolamide Hydrochloride, Timolol Maleate against supplements and herbal ingredients. Checking Dorzolamide Hydrochloride, Timolol Maleate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.