Medication interaction hub

What Supplements Interact with Edrophonium?

Edrophonium brand names: Reversol, Enlon, Tensilon. Every interaction below applies to the brands too.

22 Interactions 21 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Edrophonium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Edrophonium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Edrophonium (Tensilon, Enlon) is a short-acting medicine given in clinics, usually to test for myasthenia gravis or reverse muscle relaxants, and none of the 22 supplements on this page rise above moderate concern. Nearly all of them act the same way edrophonium does, blocking the enzyme that breaks down acetylcholine, so pairing them can push cholinergic side effects too far: cramping, drooling, sweating, a slow heart rate. Betel nut carries the strongest evidence, and huperzine A, a popular memory supplement, works by this exact mechanism.

One entry runs the other way. European barberry may blunt cholinergic drugs, which matters when an accurate response to edrophonium is the entire point. Since a clinician gives this medicine, tell whoever administers it what you take beforehand. With 21 moderate entries and a single minor one, this is a list worth checking against your supplement shelf, not a cause for alarm.

— , Clinical Pharmacist · July 18, 2026

Moderate 21 Minor 1 No known interaction 1,430

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Edrophonium: Top Interactions at a Glance

The most significant Edrophonium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 22 interacting ingredients — plus 1,430 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Edrophonium + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Betel Nut + Edrophoniumi

In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.

Read the full interaction Moderate Likelihood Possible Arenaria Rubra + Edrophoniumi

Arenaria rubra, by inhibiting acetylcholinesterase, may theoretically interact with other acetylcholinesterase inhibitors like donepezil and rivastigmine, commo...

Read the full interaction Moderate Likelihood Possible Bacopa + Edrophoniumi

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.

Read the full interaction Moderate Likelihood Possible Bael + Edrophoniumi

Bael leaf extract shows acetylcholinesterase (AChE) inhibitory activity in vitro.

Read the full interaction Moderate Likelihood Possible Boxwood + Edrophoniumi

Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Read the full interaction Moderate Likelihood Possible Calamus + Edrophoniumi

Theoretically, concurrent use of cholinergic drugs and calamus might have an additive effect and increase the risk of cholinergic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Edrophonium

All 1,452 ingredients in our database, ranked by severity — 22 with a Edrophonium interaction on file and 1,430 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Edrophonium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Poria Mushroom with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.

Full Poria Mushroom + Edrophonium answer

Can you take Purple Nut Sedge with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Edrophonium answer

Can you take Sage with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might have additive effects when used with cholinergic drugs.

Full Sage + Edrophonium answer

Can you take Syrian Rue with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the effects and adverse effects of cholinergic drugs.

Full Syrian Rue + Edrophonium answer

Can you take Teazle with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Full Teazle + Edrophonium answer

Can you take Thyme with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.

Full Thyme + Edrophonium answer

Can you take Toothed Clubmoss with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties.

Full Toothed Clubmoss + Edrophonium answer

Can you take Deanol with Edrophonium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.

Full Deanol + Edrophonium answer

Can you take Betel Nut with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.

Full Betel Nut + Edrophonium answer

Can you take Arenaria Rubra with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Arenaria rubra, by inhibiting acetylcholinesterase, may theoretically interact with other acetylcholinesterase inhibitors like donepezil and...

Full Arenaria Rubra + Edrophonium answer

Can you take Bacopa with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.

Full Bacopa + Edrophonium answer

Can you take Bael with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bael leaf extract shows acetylcholinesterase (AChE) inhibitory activity in vitro.

Full Bael + Edrophonium answer

Can you take Boxwood with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Edrophonium answer

Can you take Calamus with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cholinergic drugs and calamus might have an additive effect and increase the risk of cholinergic effects.

Full Calamus + Edrophonium answer

Can you take Clubmoss with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Full Clubmoss + Edrophonium answer

Can you take Dimethylsulfoxide (dmso) with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of cholinergic adverse effects when taken with cholinergic drugs.

Full Dimethylsulfoxide (dmso) + Edrophonium answer

Can you take European Barberry with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with cholinergic drugs might decrease the effects of cholinergic drugs.

Full European Barberry + Edrophonium answer

Can you take Huperzine A with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.

Full Huperzine A + Edrophonium answer

Can you take Iboga with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga might have additive effects with cholinergic drugs.

Full Iboga + Edrophonium answer

Can you take Marjoram with Edrophonium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Edrophonium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Edrophonium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Edrophonium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Edrophonium sits in 2 interaction categories. Open any one to see what the group means:

Cholinergic Drugs 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Edrophonium through this category.

Acetylcholinesterase (Ache) Inhibitors 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Edrophonium through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Edrophonium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Edrophonium.

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Pharmacist Counseling Corner

Edrophonium & Supplements: Common Questions

What supplements interact with Edrophonium?
Our database currently documents 22 ingredients with a known Edrophonium interaction (0 major, 21 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 22. The highest-ranked right now: Betel Nut, Arenaria Rubra, Bacopa.
Which Edrophonium supplement interactions are the most serious?
None of the Edrophonium supplement interactions on file are currently rated major. The most significant are the 21 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Edrophonium?
Plenty of supplements coexist fine with Edrophonium; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Reversol have the same supplement interactions as Edrophonium?
Yes — Reversol, Enlon, Tensilon all contain Edrophonium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Edrophonium and my other medications?
This page covers Edrophonium against supplements and herbal ingredients. Checking Edrophonium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.