Medication interaction hub

What Supplements Interact with Ertugliflozin, Metformin Hydrochloride?

Ertugliflozin, Metformin Hydrochloride brand name: Segluromet. Every interaction below applies to the brands too.

257 Interactions 2 Major 217 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ertugliflozin, Metformin Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ertugliflozin, Metformin Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take Segluromet (ertugliflozin and metformin) for type 2 diabetes, check this list before you add a supplement, not after. Two of the 257 entries are rated major: Siberian cocklebur has caused severe low blood sugar in people, and activated charcoal can soak up an oral dose before it absorbs. Most of the other 217 moderate entries either add to the glucose lowering, raising your risk of a low, or push blood sugar up and work against the drug.

A few bulking fibers and charcoal products can also cut how much of the metformin half you absorb, so keep them well separated from your dose. Even beer sits in the moderate column, since alcohol can trigger lows while its carbohydrates worsen glucose control. If you start anything from this page, test your blood sugar more often; the 38 minor entries carry far less weight than those two majors.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 217 Minor 38 No known interaction 1,195

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ertugliflozin, Metformin Hydrochloride: Top Interactions at a Glance

The most significant Ertugliflozin, Metformin Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 257 interacting ingredients — plus 1,195 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ertugliflozin, Metformin Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Ertugliflozin, Metformin Hydrochloridei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ertugliflozin, Metformin Hydrochloridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Ertugliflozin, Metformin Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 257 with a Ertugliflozin, Metformin Hydrochloride interaction on file and 1,195 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ertugliflozin, Metformin Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Chaga with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.

Full Chaga + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chicory with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chinese Cucumber with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects.

Full Chinese Cucumber + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chinese Mallow with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with Chinese mallow might increase the risk for hypoglycemia.

Full Chinese Mallow + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chirata with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chokeberry with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chokeberry + Ertugliflozin, Metformin Hydrochloride answer

Can you take Chromium with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Ertugliflozin, Metformin Hydrochloride answer

Can you take Cissus Quadrangularis with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cissus Quadrangularis + Ertugliflozin, Metformin Hydrochloride answer

Can you take Clove with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Full Clove + Ertugliflozin, Metformin Hydrochloride answer

Can you take Coca with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antidiabetes drugs.

Full Coca + Ertugliflozin, Metformin Hydrochloride answer

Can you take Cod Liver Oil with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Cod Liver Oil + Ertugliflozin, Metformin Hydrochloride answer

Can you take Codonopsis with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Codonopsis + Ertugliflozin, Metformin Hydrochloride answer

Can you take Collard with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of collard leaves and stems has been shown to reduce glucose levels.

Full Collard + Ertugliflozin, Metformin Hydrochloride answer

Can you take Colocynth with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Colocynth + Ertugliflozin, Metformin Hydrochloride answer

Can you take Combretum Micranthum with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Combretum micranthum leaf with antidiabetes drugs might increase the risk of hypoglycemia.

Full Combretum Micranthum + Ertugliflozin, Metformin Hydrochloride answer

Can you take Coriander with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Coriander + Ertugliflozin, Metformin Hydrochloride answer

Can you take Corn Silk with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking corn silk with antidiabetes drugs might increase the risk of hypoglycemia.

Full Corn Silk + Ertugliflozin, Metformin Hydrochloride answer

Can you take Corydalis Yanhusuo with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Corydalis Yanhusuo + Ertugliflozin, Metformin Hydrochloride answer

Can you take Cowhage with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.

Full Cowhage + Ertugliflozin, Metformin Hydrochloride answer

Can you take Cucumber with Ertugliflozin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.

Full Cucumber + Ertugliflozin, Metformin Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ertugliflozin, Metformin Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ertugliflozin, Metformin Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ertugliflozin, Metformin Hydrochloride sits in 4 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Ertugliflozin, Metformin Hydrochloride through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Ertugliflozin, Metformin Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ertugliflozin, Metformin Hydrochloride through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ertugliflozin, Metformin Hydrochloride through this category.

Related: does Ertugliflozin, Metformin Hydrochloride deplete any nutrients?

Ertugliflozin, Metformin Hydrochloride has 4 reported nutrient associations in the research literature — see the Ertugliflozin, Metformin Hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ertugliflozin, Metformin Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ertugliflozin, Metformin Hydrochloride.

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Pharmacist Counseling Corner

Ertugliflozin, Metformin Hydrochloride & Supplements: Common Questions

What supplements interact with Ertugliflozin, Metformin Hydrochloride?
Our database currently documents 257 ingredients with a known Ertugliflozin, Metformin Hydrochloride interaction (2 major, 217 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 257. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Ertugliflozin, Metformin Hydrochloride supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ertugliflozin, Metformin Hydrochloride?
Plenty of supplements coexist fine with Ertugliflozin, Metformin Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Segluromet have the same supplement interactions as Ertugliflozin, Metformin Hydrochloride?
Yes — Segluromet all contain Ertugliflozin, Metformin Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ertugliflozin, Metformin Hydrochloride deplete any vitamins or nutrients?
It might — Ertugliflozin, Metformin Hydrochloride has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ertugliflozin, Metformin Hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ertugliflozin, Metformin Hydrochloride and my other medications?
This page covers Ertugliflozin, Metformin Hydrochloride against supplements and herbal ingredients. Checking Ertugliflozin, Metformin Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.