Drug & supplement interaction

Apple + Ertugliflozin, Metformin Hydrochloride

Ertugliflozin, Metformin Hydrochloride brand name: Segluromet.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Apple has a moderate interaction with Ertugliflozin, Metformin Hydrochloride. Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Apple and Ertugliflozin, Metformin Hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Ertugliflozin, Metformin Hydrochloride

Ertugliflozin, Metformin Hydrochloride falls under ANTIDIABETES DRUGS — the group Apple interacts with.

Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Clinical research suggests that consuming apples or drinking apple juice can raise blood glucose levels, with the effects of drinking apple juice being more significant than consuming apples.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Segluromet combines two medicines (ertugliflozin and metformin) that work together to lower your blood sugar. Neither one is a prodrug, so this isn't about your body activating the drug. Instead, the concern here is simpler: apple juice can carry a fair amount of natural sugar, and drinking a lot of it could nudge your blood sugar up, which works against what your medication is trying to do.

Keep in mind this is theoretical, based on the sugar content rather than any direct chemical clash. A whole apple has fiber that blunts the sugar hit, so it's much gentler than juice. Enjoy apples as a normal part of your diet. If you drink juice often or notice your numbers running high, mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Apple Also Interacts With Other Medications

Apple has 47 major, 252 moderate known drug interactions in our database — the Ertugliflozin, Metformin Hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Major 47 Moderate 252 No known interaction 2,531 (incl. Ertugliflozin, Metformin Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Apple

Covers the 2,830 medications we’ve checked against Apple. Pick one to open its full report.

From our Q&A

Questions About Apple or Ertugliflozin, Metformin Hydrochloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Apple or Ertugliflozin, Metformin Hydrochloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ertugliflozin, Metformin Hydrochloride

This page covers Apple only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ertugliflozin, Metformin Hydrochloride page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Ertugliflozin, Metformin Hydrochloride page

“If you take Segluromet (ertugliflozin and metformin) for type 2 diabetes, check this list before you add a supplement, not after. Two of the 257 entries are rated major: Siberian cocklebur has caused severe low blood sugar in people, and activated charcoal can soak up an oral dose before it absorbs.”

Reviewed by 2 · Jul 18, 2026

Open the Ertugliflozin, Metformin Hydrochloride interaction page

One more smart check

Taking Apple as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,841 real supplement products containing Apple, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apple. Your product may carry other ingredients that interact with Ertugliflozin, Metformin Hydrochloride too, on top of Apple — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Apple and Ertugliflozin, Metformin Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Apple
Top 10%

#97 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ertugliflozin, Metformin Hydrochloride
Top 25%

#404 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Apple

What is Apple?

Apple
  • General nutrition and fiber intake
  • Heart and cholesterol health
  • Blood sugar and weight management
  • Digestive regularity
  • Antioxidant support

Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy diet. While research suggests apples may support heart and digestive health, most claims about concentrated apple supplements or extracts are not strongly proven, so enjoy apples as food and talk with your pharmacist before using high-dose products.

Read the full Apple monograph & all interactions
Keep checking

Other Drugs & Apple

Browse every other medication we’ve checked against Apple — both the ones with a known interaction and the ones without. Select any drug for the full detail.

47Major
252Moderate
0Minor
2,530No known interaction
47 Major 252 Moderate 2,530 No interaction
Major

47 interactions

Moderate

252 interactions

Showing 60 of 252 moderate interactions — see all 252 on the Apple page.

No interaction 2,530 drugs checked — show the list

We also checked Apple against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,530 medications checked with no known interaction — see the full Apple list.

See the full Apple interactions page
See every supplement checked against Ertugliflozin, Metformin Hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Apple monograph › Uses, safety, and every drug interaction in one place Ertugliflozin, Metformin Hydrochloride supplement interactions › Every supplement checked against Ertugliflozin, Metformin Hydrochloride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Apple and Ertugliflozin, Metformin Hydrochloride Together: Common Questions

Can you take Apple with Ertugliflozin, Metformin Hydrochloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Apple and Ertugliflozin, Metformin Hydrochloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ertugliflozin, Metformin Hydrochloride and Apple?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.