Medication interaction hub

What Supplements Interact with Nizatidine?

Nizatidine brand names: Axid, Axid Injection. Every interaction below applies to the brands too.

31 Interactions 1 Major 9 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nizatidine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nizatidine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nizatidine (Axid) reduces stomach acid to treat heartburn and ulcers, and its supplement list earns real attention rather than a passing glance. The one major-rated entry is activated charcoal, which can soak up the drug in the gut and cut how much reaches your bloodstream. Most of the rest follow two patterns: bulk fibers and gums such as glucomannan and guar gum that can blunt absorption of pills in general, and acid-raising herbs that work directly against what nizatidine is trying to do.

Of the 31 ingredients on file, one rates major, nine moderate, and 21 minor. Beer and wine also appear, since H2-blockers of this type may raise blood alcohol levels more than you would expect. For the fibers and gums, spacing them well apart from your nizatidine dose covers most of the concern, and the full entries below spell out the specifics for each one.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 9 Minor 21 No known interaction 1,421

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nizatidine: Top Interactions at a Glance

The most significant Nizatidine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 31 interacting ingredients — plus 1,421 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nizatidine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Nizatidinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Nizatidine

All 1,452 ingredients in our database, ranked by severity — 31 with a Nizatidine interaction on file and 1,421 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nizatidine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Northern Prickly Ash with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, northern prickly ash might decrease the effectiveness of H2-blockers.

Full Northern Prickly Ash + Nizatidine answer

Can you take Quassia with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of H2-blockers.

Full Quassia + Nizatidine answer

Can you take Glucomannan with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Nizatidine answer

Can you take Beer with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use might increase blood alcohol levels and adverse effects.

Full Beer + Nizatidine answer

Can you take Guar Gum with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Nizatidine answer

Can you take Gum Arabic with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Nizatidine answer

Can you take Slippery Elm with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Nizatidine answer

Can you take Tragacanth with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Nizatidine answer

Can you take Wine with Nizatidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use might increase blood alcohol levels and adverse effects.

Full Wine + Nizatidine answer

Can you take Thyroid Extract with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Nizatidine answer

Can you take Agar with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Nizatidine answer

Can you take Aletris with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that aletris increases stomach acid, aletris might decrease the effectiveness of H2-blockers.

Full Aletris + Nizatidine answer

Can you take Algin with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Nizatidine answer

Can you take Alpinia with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, alpinia might decrease the effectiveness of H2-blockers.

Full Alpinia + Nizatidine answer

Can you take Betaine Hydrochloride with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Full Betaine Hydrochloride + Nizatidine answer

Can you take Black Psyllium with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Nizatidine answer

Can you take Blessed Thistle with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Full Blessed Thistle + Nizatidine answer

Can you take Blond Psyllium with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Nizatidine answer

Can you take Calamus with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calamus might reduce the effectiveness of H2-blockers.

Full Calamus + Nizatidine answer

Can you take Calumba with Nizatidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calumba might decrease the effectiveness of H2-blockers.

Full Calumba + Nizatidine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nizatidine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nizatidine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nizatidine sits in 2 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nizatidine through this category.

H2-Blockers 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Nizatidine through this category.

About Nizatidine

Nizatidine is an H2 blocker used to treat duodenal ulcers, gastric ulcers, and acid reflux (GERD), including erosive esophagitis.

Generic name: Nizatidine  ·  Brand names: Axid, Axid Injection.

See the full Nizatidine drug information

Related: does Nizatidine deplete any nutrients?

Nizatidine has 12 reported nutrient associations in the research literature — see the Nizatidine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nizatidine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nizatidine.

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Pharmacist Counseling Corner

Nizatidine & Supplements: Common Questions

What supplements interact with Nizatidine?
More than you might expect — 31 in total, though they are far from equal: 1 are rated major, 9 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Nizatidine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nizatidine?
Usually yes — most people on Nizatidine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Axid have the same supplement interactions as Nizatidine?
Yes — Axid, Axid Injection all contain Nizatidine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nizatidine deplete any vitamins or nutrients?
It might — Nizatidine has 12 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nizatidine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nizatidine and my other medications?
This page covers Nizatidine against supplements and herbal ingredients. Checking Nizatidine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nizatidine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.