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Dietary supplement

Acai Ingredients & Drug Interactions

by Sundown Naturals

Acai label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acai against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acai is a dietary supplement by Sundown Naturals with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, weight loss, energy and vitality.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acai extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acai by Sundown Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Acai by Sundown Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Acai by Sundown Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: acai extract. Acai is a berry used in supplements primarily for antioxidant properties, though clinical evidence for most claimed benefits remains incomplete.

The softgel also holds several inactive ingredients — soybean oil, gelatin, vegetable glycerin, yellow beeswax, and soy lecithin — that serve as the capsule material and carrier.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Acai product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Acai's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“antioxidant support for health and vitality”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for acai isn't established in our data. The product is marketed for aging skin, athletic performance, erectile dysfunction, and cholesterol — but reliable evidence to rate it for any of these is insufficient.

That doesn't mean it doesn't work; it means the clinical studies we have aren't robust enough to draw firm conclusions yet.

The evidence, ingredient by ingredient Acai

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acai as a food is generally well tolerated. As a concentrated supplement, though, high-dose effects aren't well studied, so quality and long-term safety aren't fully known.

For pregnancy and breastfeeding, the data is thin: concentrated acai supplements haven't been studied in either state, so caution is advised. Talk with your pharmacist or doctor before using this during pregnancy or while breastfeeding — they can help you weigh what you know against individual circumstances.

Side effects, ingredient by ingredient Acai

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Acai.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on antidiabetes drugs (like metformin, sulfonylureas, or insulin), flag this supplement before starting — acai may interfere with blood sugar control. Check your exact medications using the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Acai is a popular antioxidant supplement, but the clinical case for it is still being built. If you take antidiabetes medications, check with us or your pharmacist first — acai may shift your blood sugar unpredictably.

Otherwise, it's well tolerated as a food, though concentrated-supplement safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acai, straight from the product label.

Brand Sundown Naturals
Barcode (UPC) 030768199661
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56590
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acai by Sundown Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
45
UPC/BARCODE
030768199661
IngredientAmount% DV
Acai extract50 mg--

Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, Soy Lecithin, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE TWO (2) SOFTGELS TWICE DAILY, PREFERABLY WITH MEALS.

Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Formulation

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

General Statements

1000 mg per serving

Fast-Acting Liquid Softgel!

Antioxidant for Health & Vitality*

Smart Facts Brazilian Acai provides natural flavonoids and antioxidants for health and vitality.* Antioxidants help protect against free radicals that can damage cells.* Rapid release softgels ensure that the active ingredients of this unique superfood are released quickly into the digestive system for optimum benefit.

SUPERFOOD from BRAZIL

Questions? Call toll free 1-888-VITAHELP (848-2435) or visit us at www.sundownnaturals.com

FDA Statement of Identity

HERBAL SUPPLEMENT

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Seals/Symbols

FREE OF Gluten & Wheat

PLEASE RECYCLE

GUARANTEED QUALITY LABORATORY TESTED

General

Prod. No. 19966 03D B19965 AAD

Brand IP Statement(s)

2014

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acai by Sundown Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acai label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acai by Sundown Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container45 Amounts shown are per serving.

Acai extract

Interacts with
86 drugs
50 mg per serving

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacki...

Acai extract monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Soy Lecithin, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acai by Sundown Naturals Drug Interactions

Want to check YOUR meds against Acai?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Acai extract 86

Individual Drug Interactions

The ingredients in Acai interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Acai interact with drugs. Each result below shows which ingredient is responsible. Acai extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Acai with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Acai extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.

Likelihood Possible Evidence D
Acai extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acai, from the product label.

Sundown Naturals

See all Sundown Naturals products
Name
Rexall Sundown, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-888-848-2435
Web Address
www.sundownnaturals.com
Pharmacist Counseling Corner

Acai by Sundown Naturals: Common Questions

Does Acai by Sundown Naturals interact with any medications?
Yes. Based on its ingredients, Acai has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acai contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does acai actually work for weight loss or cholesterol?
The evidence isn't solid enough to say yes. Our data shows insufficient reliable evidence to rate it for obesity or high cholesterol. That's not the same as saying it doesn't work — just that the clinical studies so far haven't been strong enough to prove it.
Is acai safe if I'm pregnant or breastfeeding?
Concentrated acai supplements haven't been studied in pregnancy or while breastfeeding, so there isn't enough safety data either way. Talk with your pharmacist or doctor before using it during these times — they can give you advice tailored to your situation.
What are the side effects of acai supplements?
Adverse effects aren't documented in our data for this product. Acai as a food is generally well tolerated, but high-dose effects and long-term safety of concentrated supplements aren't well studied, so we don't have a full picture.
Can I take this if I'm on diabetes medication?
You should check with your pharmacist first. Preliminary research shows acai may increase or decrease fasting blood sugar unpredictably, which could interfere with how your diabetes drugs work. Use the medication checker here or call ahead so we can review your specific medications.
What exactly is acai extract?
It's a concentrated form of acai berry, a fruit used in supplements for its antioxidant content. As a food, acai is generally safe, but we know less about concentrated supplements at higher doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Acai is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acai label
Go deeper

The Full Monographs Behind Acai’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acai

Interacts with 86 drugs

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often atta...

Read the full Acai monograph →
Sources

Sources & How We Checked

Acai's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acai 2 references
  1. Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

See these in context on the Acai monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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