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Dietary supplement

Acida-Zyme Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Acida-Zyme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acida-Zyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Acida-Zyme is a dietary supplement by Progressive Professional from Progressive Laboratories with 2 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acida-Zyme by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Acida-Zyme by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acida-Zyme by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Acida-Zyme contains 2 active ingredients: betaine hydrochloride and pepsin. Betaine hydrochloride is a form of hydrochloric acid meant to increase stomach acidity and support digestion.

Pepsin is a protease—a digestive enzyme that breaks down proteins in the stomach. The product also contains two inactive ingredients: hydroxypropyl methylcellulose and vegetable lubricant, which help form and lubricate the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme and acid support formula.
  • We looked for evidence on: Dyspepsia, indigestion, bloating, protein digestion.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for betaine hydrochloride is insufficient to rate its effectiveness for the conditions it's marketed for—indigestion, low stomach acid, poor thyroid function, diarrhea, rheumatoid arthritis, food sensitivities, and hay fever. We hold no effectiveness data for pepsin either.

Neither ingredient has established evidence in our records that would justify its use for any specific condition.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride can irritate your stomach and should not be taken if you have ulcers, gastritis, or true acid reflux—it may worsen those conditions. It may cause heartburn.

The product should be avoided in pregnancy because there isn't enough safety data. During breastfeeding, safety has not been established, so avoid it.

Pepsin is generally well tolerated for most adults, but it may cause digestive upset or allergic reactions in some people. In rare cases, occupational exposure to pepsin as an airborne powder has caused allergic rhinitis or asthma in workers.

Safety in pregnancy and breastfeeding has not been established; if you're pregnant or breastfeeding, talk to your pharmacist or doctor before use.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take proton pump inhibitors (PPIs), H2-blockers, or antacids. All three drug types may become less effective if you add betaine hydrochloride.

No interactions are documented for pepsin in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is marketed to support stomach acid and digestion, but the evidence for either ingredient is insufficient. If you take any acid-reducing medication—PPIs, H2-blockers, or antacids—check your specific drugs with the tool on this page before starting.

If you have ulcers, gastritis, or acid reflux, this product isn't appropriate for you. Talk to your pharmacist about whether it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acida-Zyme, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821004082
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299153
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acida-Zyme by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
Servings per container
90
UPC/BARCODE
351821004082
IngredientAmount% DV
Betaine Hydrochloride750 mg--
Pepsin45 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Vegetable Lubricant

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: One vegetable capsule after each meal, or as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health care professional.

Not to be used by pregnant or lactating women.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of reach of children.

Contains: Milk

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Digestive Aid

Seals/Symbols

Certified GMP Compliant GMP Good Manufacturing Practices 21 CFR 111

Formula

Betaine HCI and Pepsin

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acida-Zyme by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acida-Zyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acida-Zyme by Progressive Professional from Progressive Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
750 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pepsin

No known
interactions
45 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Vegetable Lubricant. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acida-Zyme by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against Acida-Zyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Acida-Zyme interact with 36 drugs. Click any drug to see the details.

1 of the 2 ingredients in Acida-Zyme interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Acida-Zyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acida-Zyme, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Acida-Zyme by Progressive Professional from Progressive Laboratories: Common Questions

Does Acida-Zyme by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, Acida-Zyme has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acida-Zyme contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or GERD?
No. Betaine hydrochloride increases stomach acid and is not safe for people with true acid reflux or gastritis. This product could make those conditions worse. Talk to your pharmacist about what's actually appropriate for you.
Will this work if I'm already taking an antacid or PPI?
Probably not as well as the antacid or PPI is meant to. Betaine hydrochloride increases stomach acid, which directly opposes what those medications do. You shouldn't take them together without advice from your pharmacist.
Is there any proven evidence this helps with digestion?
The evidence is insufficient to rate. We don't hold established proof that either betaine hydrochloride or pepsin works for indigestion or any of the other uses claimed on the label.
Is it safe to use while pregnant or breastfeeding?
No. Betaine hydrochloride should be avoided in pregnancy because there isn't enough safety data. Pepsin safety in pregnancy hasn't been established either. Neither ingredient is recommended during breastfeeding without medical advice. Talk to your pharmacist or doctor if you're pregnant or nursing.
Can this cause side effects?
Yes. Betaine hydrochloride may irritate your stomach and cause heartburn, especially if you have ulcers or gastritis. Pepsin may cause digestive upset or, rarely, allergic reactions. In people exposed to airborne pepsin powder occupationally, allergic rhinitis and asthma have occurred.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acida-Zyme label
Go deeper

The Full Monographs Behind Acida-Zyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Acida-Zyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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