Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Gly-Control Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Gly-Control label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gly-Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gly-Control is a dietary supplement by Progressive Professional from Progressive Laboratories with 7 active ingredients. Its ingredients are commonly taken for blood sugar and diabetes support, athletic performance and muscle building, lowering cholesterol.Based on those ingredients, 1,140 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema extract, Cinnamon extract, Bitter Melon extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gly-Control by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Gly-Control by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gly-Control by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Gly-Control contains seven active ingredients. Vanadium is a mineral that may support blood sugar control; gymnema is an herbal extract traditionally used in blood sugar management; ecklonia cava is a brown seaweed extract; bitter melon is a vegetable extract with a long history in traditional medicine; chromium is a mineral cofactor involved in glucose metabolism; cinnamon extract comes from the bark of cinnamon trees; and goat's rue is a plant powder.

Three inactive ingredients — hydroxypropylmethylcellulose, glyceryl monostearate, and rice flour — are fillers and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Blood sugar support and glucose metabolism.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Dyslipidemia, Hyperlipidemia, Hypercholesterolemia — and 4 related terms.
  • The strongest evidence on file: Vanadium is rated "Likely Effective" for Vanadium deficiency (Natural Medicines).
  • Also on file: Chromium is rated "Likely Effective" for Chromium deficiency.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

For most of the uses this product may be marketed for, the evidence in our data is insufficient to rate how well it works. Vanadium shows likely effectiveness for vanadium deficiency, but insufficient evidence for athletic performance, cancer, diabetes, and high cholesterol.

Ecklonia cava shows possibly effective evidence for high cholesterol only. Chromium is possibly effective for diabetes and likely effective for chromium deficiency, but possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Gymnema, bitter melon, and cinnamon all show insufficient evidence for diabetes and the other conditions listed. Goat's rue has insufficient evidence for lactation support.

The evidence, ingredient by ingredient Vanadium Gymnema Ecklonia Cava Bitter Melon Chromium Cassia Cinnamon Goat's Rue

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vanadium at supplement doses can cause gastrointestinal side effects — stomach discomfort, diarrhea, gas, and nausea — especially above 1.8 mg daily; in rare cases, long-term high doses have caused kidney damage. Gymnema is generally well tolerated short-term but can lower blood sugar; a rare case of drug-induced liver inflammation has been reported.

Ecklonia cava caused hair loss in one trial participant and nausea or heartburn in others; it also contains iodine, which may be a concern for those sensitive to seaweed. Bitter melon commonly causes gastrointestinal upset in 3% to 16% of users and rarely may harm the kidneys.

Chromium is usually tolerated but can cause irritability, mood changes, headaches, and insomnia; serious cases of anemia and blood disorders have been rare. Cinnamon extract at high doses over time may stress the liver due to its coumarin content; a rash and one case of low blood sugar seizure have been reported.

Goat's rue has limited human safety data; the fresh plant is toxic. For pregnancy and breastfeeding: vanadium supplements should be avoided during pregnancy and breastfeeding; gymnema and ecklonia cava should be avoided during both due to insufficient data; bitter melon is traditionally avoided in pregnancy but safety during breastfeeding is unclear; chromium from food or prenatal vitamins is generally acceptable, but extra supplement doses should be avoided unless your doctor advises otherwise; cinnamon food amounts are likely safe, but high supplement doses should be avoided; and goat's rue data are insufficient — discuss with your doctor or pharmacist.

Side effects, ingredient by ingredient Vanadium Gymnema Ecklonia Cava Bitter Melon Chromium Cassia Cinnamon Goat's Rue

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Goat's Rue, Vanadium, Bitter Melon, Gymnema, Chromium, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gly-Control, check with your doctor or pharmacist if you take blood thinners (anticoagulant or antiplatelet drugs like warfarin, aspirin, or clopidogrel) — vanadium, cinnamon, and goat's rue may increase bleeding risk. If you take diabetes medications or insulin, watch for signs of low blood sugar — vanadium, gymnema, bitter melon, chromium, and cinnamon all may lower blood glucose.

If you take levothyroxine for thyroid disease, chromium may reduce its absorption. Also check if you take drugs processed through your liver's CYP1A2 or CYP2C9 pathways, or drugs affected by P-glycoprotein — gymnema and bitter melon may alter their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gly-Control is formulated for blood sugar support, but most of its ingredients lack strong evidence for that purpose. If you take diabetes medications, blood thinners, levothyroxine, or any other regular prescription, check your medication list against the interaction tool on this page before you start.

If you're pregnant, breastfeeding, or have kidney or liver concerns, talk with your doctor or pharmacist about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gly-Control, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821010502
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261228
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gly-Control by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetable Capsule(s)
Maximum serving Sizes:
2 Vegetable Capsule(s)
Servings per container
60
UPC/BARCODE
351821010502
IngredientAmount% DV
Vanadium50 mcg--
Gymnema extract500 mg--
Ecklonia cava extract10 mg--
Bitter Melon extract450 mg--
Chromium200 mcg167%
Cinnamon extract125 mg--
Goat's Rue, Powder150 mg--

Other ingredients: Hydroxypropylmethylcellulose, Glyceryl Monostearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Directions: Two vegetable capsules twice daily, or more, as recommended by a health care professional.

Sold only for dispensing by a licensed health care professional

Formulated by Mitchell A. Fleisher , M.D, D.Ht, D.A.B.F.M., Dc.A.B.C.T.

Precautions

Pregant and/or lactating women should consult their physician prior to use.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of reach of children.

Brand IP Statement(s)

Zychrome is a registered trademark of InterHealth Nutraceuticals, Inc. Seanol P is a registered trademark of Simply Healthy, LLC. Cinnulin PF is a registered trademark of Integrity Nutraceuticals International.

Progressive Professional from Progressive Laboratories

Formulation

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Clinically formulated to support normal range blood sugar levels

Seals/Symbols

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Formula

Zychrome Cinnulin PF and Seanol P

FDA Statement of Identity

Herbal-Mineral Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gly-Control by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gly-Control label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gly-Control by Progressive Professional from Progressive Laboratories

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetable Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vanadium

Interacts with
208 drugs
50 mcg per serving Form: Bis-Glycinato OxoVanadium

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...

Vanadium monograph & interactions

Gymnema extract

Interacts with
851 drugs
500 mg per serving

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema extract monograph & interactions

Ecklonia cava extract

No known
interactions
10 mg per serving Form: Phlorotannin

Ecklonia cava is an edible brown seaweed rich in plant compounds called phlorotannins that are studied as antioxidants. Early human and lab research h...

Ecklonia cava extract monograph & interactions

Bitter Melon extract

Interacts with
282 drugs
450 mg per serving

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...

Bitter Melon extract monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Dinicocysteinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Cinnamon extract

Interacts with
442 drugs
125 mg per serving

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

Cinnamon extract monograph & interactions

Goat's Rue, Powder

Interacts with
122 drugs
150 mg per serving Form: Galega officinalis

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research....

Goat's Rue, Powder monograph & interactions

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Glyceryl Monostearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gly-Control by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against Gly-Control?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,140Drugs
794 Moderate 346 Minor

Ingredients driving the most interactions

Gymnema extract 851
Cinnamon extract 442
Bitter Melon extract 282
Vanadium 208
Chromium 178

Individual Drug Interactions

The ingredients in Gly-Control interact with 1,140 drugs. Click any drug to see the details.

6 of the 7 ingredients in Gly-Control interact with drugs. Each result below shows which ingredient is responsible. Gymnema extract Cinnamon extract Bitter Melon extract Vanadium Chromium Goat's Rue, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Gly-Control with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema extract full monograph & interactions

Cinnamon extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon extract full monograph & interactions

Bitter Melon extract3 drug types · 282 drugs

Antidiabetes Drugs

Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Pazopanib (Votrient)

Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Bitter Melon extract full monograph & interactions

Vanadium2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Goat's Rue, Powder1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Laboratory research suggests that goat's rue extract can inhibit platelet aggregation. Theoretically, goat's rue might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Goat's Rue, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gly-Control, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Gly-Control by Progressive Professional from Progressive Laboratories: Common Questions

Does Gly-Control by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, Gly-Control has a known interaction with 1,140 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gly-Control contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Gly-Control help my diabetes?
Most of the ingredients in Gly-Control, including vanadium, gymnema, bitter melon, and cinnamon, have insufficient reliable evidence for diabetes in the data we hold. Only chromium shows possibly effective evidence for diabetes. Talk with your doctor about whether this product fits into your diabetes plan.
Can I take Gly-Control if I'm pregnant?
No — vanadium supplements, gymnema, and ecklonia cava should be avoided during pregnancy. Bitter melon is traditionally avoided in pregnancy. Cinnamon food amounts are likely safe, but high supplement doses should be avoided. Chromium from food or a prenatal vitamin is fine, but extra supplement doses need your doctor's approval. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning pregnancy.
What are the most common side effects I might notice?
Vanadium, gymnema, bitter melon, and chromium can all cause gastrointestinal upset — stomach discomfort, gas, nausea, or diarrhea. Chromium may also cause headaches, irritability, or mood changes. Ecklonia cava caused nausea in one trial. Most people tolerate these ingredients at typical doses, but effects vary.
Can I take Gly-Control if I'm taking thyroid medication?
If you take levothyroxine (Synthroid), chromium in this product may bind it in your intestines and reduce how much your body absorbs. Talk with your doctor or pharmacist about spacing — they may recommend taking your thyroid medication apart from this supplement.
Can I take Gly-Control while breastfeeding?
Vanadium, gymnema, and ecklonia cava should be avoided while breastfeeding due to insufficient safety data. Bitter melon has unclear data — it's traditionally used to support lactation but safety is limited, so professional guidance is important. Chromium and cinnamon at food levels are generally acceptable. Talk with your doctor or pharmacist.
Does Gly-Control have any fillers or artificial ingredients?
The inactive ingredients are hydroxypropylmethylcellulose (a capsule material), glyceryl monostearate, and rice flour. These are common excipients used in supplement capsules.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gly-Control label
Go deeper

The Full Monographs Behind Gly-Control’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph → Herb & supplement monograph

Ecklonia Cava

Ecklonia cava is an edible brown seaweed rich in plant compounds called phlorotannins that are studied as antioxidants. Early human and lab research hints at possible benefits for blood vess...

Read the full Ecklonia Cava monograph → Herb & supplement monograph

Bitter Melon

Interacts with 282 drugs

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evid...

Read the full Bitter Melon monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Goat's Rue

Interacts with 122 drugs

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research. Solid human evidence for either use is...

Read the full Goat's Rue monograph →
Sources

Sources & How We Checked

Gly-Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 125 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vanadium 15 references
  1. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
  2. Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
  3. Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
  4. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
  5. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
  6. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
  9. Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
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Gymnema 12 references
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Ecklonia Cava 1 reference
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Bitter Melon 18 references
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Chromium 53 references
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Cassia Cinnamon 20 references
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Goat's Rue 6 references
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  2. Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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