Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Advanced Anti-Adipocyte Ingredients & Drug Interactions

by Life Extension

Advanced Anti-Adipocyte label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Anti-Adipocyte against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Anti-Adipocyte is a dietary supplement by Life Extension with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garcinia mangostana extract, Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Anti-Adipocyte by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Anti-Adipocyte by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Anti-Adipocyte by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Meratrim Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

This product has three active ingredients. Garcinia mangostana extract (from the mangosteen fruit) and Irvingia gabonensis extract (African mango) are both included for their potential effects on body composition.

Meratrim is a proprietary blend — its specific components aren't listed here, so we can't detail what's in it. The remaining ingredient, Sphaeranthus indicus extract, rounds out the formula.

The capsule itself is made from vegetable cellulose, along with microcrystalline cellulose, silica, and vegetable stearate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Weight management and metabolic support.
  • We looked for evidence on: Obesity, Metabolic syndrome, Hypercholesterolemia, Diabetes, Appetite control, Weight loss.
  • The closest evidence on file: Mangosteen is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for what this product actually does is limited. Garcinia mangostana has possibly effective evidence for periodontitis (gum disease), but for androgenic alopecia (male-pattern hair loss) and Alzheimer's disease, we don't have enough reliable evidence to rate it.

Irvingia gabonensis similarly shows insufficient evidence for diabetes, high cholesterol, obesity, or metabolic syndrome — the studies we hold don't establish it works for those uses. The effectiveness of the other ingredients isn't established in our data.

The evidence, ingredient by ingredient Mangosteen Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Garcinia mangostana extract is generally well tolerated as a food, but long-term safety of concentrated supplements hasn't been well studied. At doses up to 560 mg daily in studies, some people reported mild tiredness, headache, dizziness, malaise, and various digestive complaints including constipation, bloating, nausea, diarrhea, and abdominal discomfort — though it's unclear whether mangosteen was the cause.

Irvingia gabonensis is generally well tolerated short-term, with the most common side effects being flatulence, headache, insomnia, and nausea. One case of liver inflammation (hepatitis) has been reported after taking Irvingia at 350 mg twice daily, though this is very rare.

The safety notes advise against this product during pregnancy and breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Mangosteen Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Mangosteen, Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before taking this if you're on any of the following: blood thinners or antiplatelet drugs (Moderate risk of bleeding), diabetes medications (Moderate risk of low blood sugar with dose adjustment needed), testosterone products (Moderate additive effects possible), or donepezil for Alzheimer's (Minor risk of increased effects). We have no interaction data for Sphaeranthus indicus extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on blood thinners, diabetes medications, or testosterone therapy, or if you take donepezil, talk to your pharmacist before starting this. The active ingredients haven't been proven to work for weight management or most other uses in our data.

Long-term safety is not well established, and this product should be avoided in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Anti-Adipocyte, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870150961
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231921
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Anti-Adipocyte by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870150961
IngredientAmount% DV
Garcinia mangostana extract0 NP--
Meratrim Proprietary Blend400 mg--
Sphaeranthus indicus extract0 NP--
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract150 mg--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule twice daily 30 minutes before meals, or as recommended by a healthcare practitioner.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Precautions

Caution: If you are taking blood glucose lowering medication, consult your healthcare provider before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Certified Authentic Irvingia

Formulated with meratrim and integra-lean african mango irvingia

Seals/Symbols

Non GMO LE Certified

Formulation

Non GMO LE Certified

Weight management support

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Integra-Lean Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. IGOB-131 proprietary extract is a registered trademark of Gateway Health Alliances, Inc. Meratrim is a proprietary ingredient derived from natural plant extracts exclusively distributed by InterHealth N.I.

Storage

Store tightly closed in a cool, dry place.

General Statements

Scan for product info

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See for yourself

Advanced Anti-Adipocyte by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Anti-Adipocyte label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Anti-Adipocyte by Life Extension

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Meratrim Proprietary Blend

400 mg per serving

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Interacts with
94 drugs
150 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Anti-Adipocyte by Life Extension Drug Interactions

Want to check YOUR meds against Advanced Anti-Adipocyte?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
216 Moderate 3 Minor

Ingredients driving the most interactions

Garcinia mangostana extract 125
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract 94

Individual Drug Interactions

The ingredients in Advanced Anti-Adipocyte interact with 219 drugs. Click any drug to see the details.

2 of the 3 ingredients in Advanced Anti-Adipocyte interact with drugs. Each result below shows which ingredient is responsible. Garcinia mangostana extract Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Anti-Adipocyte with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Garcinia mangostana extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Garcinia mangostana extract full monograph & interactions

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Anti-Adipocyte, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Advanced Anti-Adipocyte by Life Extension: Common Questions

Does Advanced Anti-Adipocyte by Life Extension interact with any medications?
Yes. Based on its ingredients, Advanced Anti-Adipocyte has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Anti-Adipocyte contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking first. The mangosteen extract in this product theoretically raises bleeding risk when combined with blood thinners or antiplatelet drugs — it's a Moderate interaction. You need to talk with your pharmacist or doctor before adding this.
What side effects should I watch for?
The most commonly reported ones are mild: tiredness, headache, dizziness, and digestive issues like bloating, nausea, or diarrhea. There's also one rare case of liver inflammation on file. If you develop jaundice, belly pain, or malaise, stop and contact your doctor right away.
Does this actually work for weight loss?
The evidence isn't established in the data we hold. Neither of the main plant extracts — mangosteen or African mango — has reliable evidence for obesity or body composition, so we can't say whether this product does what it claims.
Can I take this while pregnant or breastfeeding?
No. The safety notes advise against both ingredients during pregnancy and while breastfeeding because there isn't enough safety information. Talk with your doctor or pharmacist if you're considering it.
What is Meratrim, and why isn't it detailed?
Meratrim is a proprietary blend, which means the exact ingredients and their amounts aren't listed on the label — it's a trade secret. Because we don't know what's in it, we can't tell you what each component does or check it for interactions.
I take a diabetes medication. Is this safe?
The African mango extract in this product may lower blood sugar and increase the risk of low blood sugar when combined with diabetes drugs — that's a Moderate interaction. You'd need close blood sugar monitoring and your dose might need adjusting. Check with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Anti-Adipocyte is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Anti-Adipocyte label
Go deeper

The Full Monographs Behind Advanced Anti-Adipocyte’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph → Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Advanced Anti-Adipocyte's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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