Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Advanced Cholesterol Formula Ingredients & Drug Interactions

by The Vitamin Shoppe

Advanced Cholesterol Formula label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Cholesterol Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Advanced Cholesterol Formula is a dietary supplement by The Vitamin Shoppe with 4 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tocomin Palm fruit Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Cholesterol Formula by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Cholesterol Formula by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Cholesterol Formula by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Sytrinol” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

Advanced Cholesterol Formula has 4 active ingredients designed to support cholesterol and heart health. Tocomin Palm fruit Tocotrienols are a form of vitamin E; Heart Choice Phytosterol Concentrate contains plant sterols that may help lower cholesterol; natural Citrus Polymethoxylated Flavones are compounds from citrus; and OleaSelect Olive fruit extract comes from olives.

The capsules also contain inactive ingredients — cellulose, dicalcium phosphate, magnesium stearate, and silica — which help form and stabilize the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy cholesterol and cardiovascular health.
  • We looked for evidence on: Hypercholesterolemia, Metabolic syndrome, Stroke, Diabetes, heart health, blood pressure — and 1 related terms.
  • The strongest evidence on file: Tocotrienols is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia.
  • Also on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.

The evidence for these ingredients is mixed. Tocotrienols show possibly effective for diabetes, but the data on whether the formula actually lowers cholesterol is labeled possibly ineffective.

For olive extract, the evidence isn't yet established for conditions like osteoarthritis, osteoporosis, or infection prevention — we simply don't have reliable data. The phytosterol and citrus flavone ingredients don't have effectiveness ratings on file, so we can't say whether they work for any specific condition based on our data.

The evidence, ingredient by ingredient Tocotrienols Olive

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tocotrienols are generally well tolerated in studies, though long-term safety at supplement doses isn't firmly established. It's not recommended in pregnancy because there isn't enough safety data; during breastfeeding, avoid it unless your doctor says it's okay.

Olive extract is also well tolerated when taken orally in typical amounts, but concentrated supplements are less studied than the whole food. In pregnancy, avoid concentrated olive supplements without your doctor's approval; during breastfeeding, the same caution applies.

A small number of trial participants reported headache and stomach discomfort with olive extract.

Side effects, ingredient by ingredient Tocotrienols Olive

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs — warfarin, aspirin, clopidogrel, and similar medications — because tocotrienols may increase bleeding risk. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This formula may be worth considering if you're looking for plant-based cholesterol support and don't take blood thinners. If you're on any anticoagulant or antiplatelet medication, talk to your pharmacist first — the tocotrienols could theoretically raise bleeding risk.

Pregnancy, breastfeeding, and long-term use all warrant a conversation with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Cholesterol Formula, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536042517
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 35609
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Cholesterol Formula by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
766536042517
IngredientAmount% DV
Heart Choice(R) Phytosterol Concentrate1300 mg, 650 mg--
Sytrinol300 mg, 150 mg--
natural Citrus Polymethoxylated Flavones0 NP, 0 NP--
Tocomin Palm fruit Tocotrienols0 NP, 0 NP--
OleaSelect(R) Olive fruit extract50 mg, 25 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

specialty

clinically studied ingredient cholesterol cardiovascular

{veggie capsule} actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free nut free

Does not contain: Yeast, Wheat, Gluten, Sugar, Salt, Dairy, Fish, Animal Derivatives, Preservatives, Artificial Colors or Flavors.

Formula

Contains: Soy.

Precautions

Contains: Soy.

WARNING: Do not use if you are pregnant, nursing, or planning to have surgery. Please consult your physician prior to use if you have any medical conditions or are taking any medication, especially anticoagulants.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take two (2) veggie capsules twice daily, preferably with meals.

Storage

STORE IN A COOL, DRY PLACE.

Seals/Symbols

heart choice(TM)

Sytrinol

Brand IP Statement(s)

Heart Choice(R), Nature’s Choice for a Healthy Heart is registered with Cognis.

Sytrinol(R) is a registered trademark of Next Pharmaceuticals. Tocomin(R) is a registered trademark of Carotech BHD. OleaSelect(R) is a registered trademark of Indena.

General

Item No. VS-4251 1776731 CO 3

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Cholesterol Formula by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Cholesterol Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Cholesterol Formula by The Vitamin Shoppe

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Heart Choice(R) Phytosterol Concentrate

1300 mg per serving

Sytrinol

300 mg per serving

OleaSelect(R) Olive fruit extract

No known
interactions
50 mg per serving Form: Hydroxytyrosol, Total Polyphenols, Verbascosides

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

OleaSelect(R) Olive fruit extract monograph & interactions

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Cholesterol Formula by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Advanced Cholesterol Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Tocomin Palm fruit Tocotrienols 122

Individual Drug Interactions

The ingredients in Advanced Cholesterol Formula interact with 122 drugs. Click any drug to see the details.

1 of the 4 ingredients in Advanced Cholesterol Formula interact with drugs. Each result below shows which ingredient is responsible. Tocomin Palm fruit Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Cholesterol Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tocomin Palm fruit Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocomin Palm fruit Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Cholesterol Formula, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Advanced Cholesterol Formula by The Vitamin Shoppe: Common Questions

Does Advanced Cholesterol Formula by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Advanced Cholesterol Formula has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Cholesterol Formula contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin or warfarin?
Not without talking to your pharmacist first. Tocotrienols in this formula may increase the risk of bleeding when combined with blood thinners or antiplatelet drugs like aspirin or warfarin. It hasn't happened in actual patients that we know of, but the concern is real enough that you need a quick check.
Will this actually lower my cholesterol?
The evidence doesn't strongly support that yet. Tocotrienols show possibly ineffective for cholesterol based on available data, and the other ingredients don't have enough reliable research to say either way. It's best to check with your doctor about whether this fits your cholesterol plan.
Is it safe to take while pregnant?
No — there isn't enough safety data on the tocotrienols and olive extract at supplement doses during pregnancy. Talk with your doctor or pharmacist before using this if you're pregnant or planning to be.
What does tocotrienol do?
Tocotrienol is a form of vitamin E. It shows possibly effective for diabetes in the research we hold, but its use in this cholesterol formula hasn't been proven to lower cholesterol levels.
Are there any common side effects?
Both tocotrienols and olive extract are well tolerated in studies. No adverse effects were reported in tocotrienol trials. With olive extract, a small number of people reported headache and stomach discomfort.
What are the inactive ingredients?
The capsule contains cellulose, dicalcium phosphate, magnesium stearate, and silica — standard binders and fillers that help hold the formula together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Cholesterol Formula is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Cholesterol Formula label
Go deeper

The Full Monographs Behind Advanced Cholesterol Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph →
Sources

Sources & How We Checked

Advanced Cholesterol Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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