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Dietary supplement

Beta 1,3 Glucans Ingredients & Drug Interactions

by The Vitamin Shoppe

Beta 1,3 Glucans label
See full label image
Tablet Or Pill Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beta 1,3 Glucans against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Beta 1,3 Glucans is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta 1,3 Glucans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Beta 1,3 Glucans by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Beta 1,3 Glucans by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Beta 1,3 Glucans by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: beta 1,3 glucans. These are naturally occurring carbohydrates found in foods like mushrooms, oats, and yeast, and they're included here in a concentrated supplement form.

The tablet also contains several inactive ingredients—dicalcium phosphate, microcrystalline cellulose, stearic acid, magnesium stearate, and others—that help bind and protect the active compound.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Beta-glucans's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune support and cellular health.
  • We looked for evidence on: Cancer, Critical illness (trauma), Exercise-induced respiratory infections, Lower respiratory tract infections, Upper respiratory tract infection (URTI), Wound healing — and 2 related terms.
  • The closest evidence on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Exercise-induced respiratory infections, Lower respiratory tract infections, Wound healing, and more.

Beta 1,3 glucans are likely effective for lowering cholesterol and triglycerides (dyslipidemia) and for supporting heart health in people with coronary heart disease. That's what the clinical evidence shows.

The supplement appears to work partly by helping manage blood pressure and blood lipid levels, both important for cardiovascular protection.

The evidence, ingredient by ingredient Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated. However, concentrated supplement doses lack the long-term safety data that food sources have, so use caution if you're taking a high-dose supplement.

When applied to skin in clinical trials, some people experienced mild contact dermatitis and skin reactions; these were temporary and self-limited. One rare case in children taking very high oral doses showed temporary liver enzyme changes.

There isn't enough data on supplement doses during breastfeeding to know either way—talk with your doctor or pharmacist before taking this while nursing.

Side effects, ingredient by ingredient Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you're on blood pressure medication (antihypertensives) or any immunosuppressant drugs—both carry a moderate-severity interaction risk with beta-glucans.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Beta-glucans may help if you're concerned about cholesterol or heart health and want an evidence-based supplement. If you take blood pressure medication or any drug that suppresses your immune system, check with your doctor or pharmacist before starting—the interaction risk is moderate and worth confirming with your own prescriber.

Most people tolerate it well, but high-dose supplements are less studied than food sources.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta 1,3 Glucans, straight from the product label.

Brand The Vitamin Shoppe
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 13043
Product type Fiber And Other Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta 1,3 Glucans by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
60
IngredientAmount% DV
Beta 1,3 Glucans200 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, purified Water, Methylcellulose, Polyethylene Glycol, Titanium Dioxide, Caramel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

SINCE 1977

Extracted from Yeast Cell Wall

Natural Food Supplements

Numerous experimental studies have shown beta-glucan to activate white blood cells known as macrophages and neutrophillis can recognize and kill tumor cells, remove cellular debris resulting from oxidative damage tissue, and further activate other components of the immune system.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions As a dietary supplement, take one (1) to three (3) tablets daily, preferably with a meal.

Precautions

Warning KEEP OUT OF REACH OF CHILDREN.

Formulation

Does not Contain: Corn, Wheat, Sugar, Salt, Starch, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors Added.

General

Item #: VS-1709/1466320

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beta 1,3 Glucans by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beta 1,3 Glucans label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beta 1,3 Glucans by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Beta 1,3 Glucans

Interacts with
293 drugs
200 mg per serving Form: Saccharomyces cerevisiae

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta 1,3 Glucans monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Purified Water, Methylcellulose, Polyethylene Glycol, Titanium Dioxide, Caramel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta 1,3 Glucans by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Beta 1,3 Glucans?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Beta 1,3 Glucans 293

Individual Drug Interactions

The ingredients in Beta 1,3 Glucans interact with 293 drugs. Click any drug to see the details.

1 of the 1 ingredient in Beta 1,3 Glucans interact with drugs. Each result below shows which ingredient is responsible. Beta 1,3 Glucans

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta 1,3 Glucans with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta 1,3 Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta 1,3 Glucans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beta 1,3 Glucans, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
The Vitamin Shoppe
Pharmacist Counseling Corner

Beta 1,3 Glucans by The Vitamin Shoppe: Common Questions

Does Beta 1,3 Glucans by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Beta 1,3 Glucans has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta 1,3 Glucans contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually lower cholesterol?
Yes—beta-glucans are likely effective for reducing cholesterol and triglycerides. Clinical research backs that up, which is why they're often recommended for heart health.
What are beta-glucans, and where do they come from?
They're natural carbohydrates found in mushrooms, oats, yeast, and other foods. This supplement is a concentrated form, so you're getting a higher dose than you'd normally eat.
Can I take this if I'm breastfeeding?
There isn't enough research on supplement doses during breastfeeding to know either way. Talk with your doctor or pharmacist about whether it's right for you right now.
What side effects should I watch for?
Orally, beta-glucans are generally well tolerated. Rare cases at very high doses have shown temporary liver enzyme changes. If you notice yellowing of skin or eyes, severe nausea, or other unusual symptoms, contact your doctor.
Is it safe if I take a blood pressure medication?
Not automatically—beta-glucans themselves may lower blood pressure, so combining them with blood pressure drugs is a moderate-severity concern. Check with your own doctor or pharmacist before adding this to your routine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta 1,3 Glucans label
Go deeper

The Full Monographs Behind Beta 1,3 Glucans’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Beta 1,3 Glucans's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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