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Dietary supplement

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor Ingredients & Drug Interactions

by NutriRise

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Methyl B-12 1000 mcg Natural Cherry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor is a dietary supplement by NutriRise with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B-12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin B-12 (in the methyl form, methylcobalamin), supplied at 1,000 micrograms per tablet. B-12 is an essential vitamin your body needs for nerve function, red blood cell formation, and DNA synthesis.

The tablet also contains several inactive ingredients — sorbitol, fructose, mannitol, croscarmellose sodium, natural cherry flavor, silicon dioxide, lecithin, and vegetable magnesium stearate — which help bind, flavor, and preserve the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Vitamin B12's overall clinical evidence instead.

Strong

Strong clinical evidence supports Vitamin B12 for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Natural Medicines).
  • On file: Cyanide poisoning — rated "Likely Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).
  • On file: Postherpetic neuralgia — rated "Possibly Effective" (Natural Medicines).

Vitamin B-12 is effective for treating B-12 deficiency and Imerslund-Grasbeck disease (a rare genetic condition that prevents B-12 absorption). It's likely effective for cyanide poisoning.

For canker sores and a nerve pain condition called postherpetic neuralgia, the evidence is less clear — the rating is "possibly effective," meaning there's some support but not yet strong proof.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B-12 is generally very well tolerated, and your body excretes any excess in your urine, so there's no established upper limit for how much you can safely take. It's considered safe during pregnancy and breastfeeding at recommended amounts — in fact, B-12 is needed during both.

A very small number of people have reported allergic reactions such as rash or itching, potentially linked to the cobalt in the B-12 molecule itself. Serious side effects are rare; correcting a severe B-12 deficiency can theoretically lower potassium levels dangerously, but this happens very infrequently.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (Glucophage) for type 2 diabetes, the main thing to watch is that this medication can lower your B-12 levels, which is exactly why you may be taking this supplement. A Minor interaction means it's manageable, but let your doctor or pharmacist know so they can keep an eye on your levels.

No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

This is a solid choice if you have B-12 deficiency or need B-12 supplementation for a related condition. If you take metformin for diabetes, let us know — we may want to monitor your B-12 levels or adjust your dosing.

B-12 is safe in pregnancy and breastfeeding. Check your other medications with our search tool before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Methyl B-12 1000 mcg Natural Cherry Flavor, straight from the product label.

Brand NutriRise
Net contents 100 Chewable Tablet(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 257144
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
100
IngredientAmount% DV
Vitamin B-121000 mcg42667%

Other ingredients: Sorbitol, Fructose, Mannitol, Croscarmellose Sodium, natural Cherry flavor, Silicon Dioxide, Lecithin, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Get your free bottle at FREE.NUTRIRISE.COM

Please recycle

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tablet taken 1-3 times daily preferably with meals or as directed by a healthcare professional. For best results, chew tablet thoroughly before swallowing.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish, and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Allergen Warning: Contains soy [lecithin].

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Non-GMO

Healthy Metabolism Support Supports brain function Supports energy levels Great-tasting & delicious

This formula contains no animal by-products.

Made with natural ingredients

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Manufactured in USA with globally-sourced ingredients FDA Registered Facility Lab tested 3rd party tested certified for purity & potency

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Vitamin B-12

Interacts with
20 drugs
1000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B-12 monograph & interactions

Other (inactive) ingredients: Sorbitol, Fructose, Mannitol, Croscarmellose Sodium, Natural Cherry flavor, Silicon Dioxide, Lecithin, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise Drug Interactions

Want to check YOUR meds against Advanced Methyl B-12 1000 mcg Natural Cherry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B-12 20

Individual Drug Interactions

The ingredients in Advanced Methyl B-12 1000 mcg Natural Cherry Flavor interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Advanced Methyl B-12 1000 mcg Natural Cherry Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin B-12

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Methyl B-12 1000 mcg Natural Cherry Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B-121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B-12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Methyl B-12 1000 mcg Natural Cherry Flavor, from the product label.

NutriRise

See all NutriRise products
Name
NutriRise
City
Austin
State
TX
ZipCode
78701
Phone Number
1 (855) 302-3867
Web Address
http://nutririse.com
Pharmacist Counseling Corner

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise: Common Questions

Does Advanced Methyl B-12 1000 mcg Natural Cherry Flavor by NutriRise interact with any medications?
Yes. Based on its ingredients, Advanced Methyl B-12 1000 mcg Natural Cherry Flavor has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Methyl B-12 1000 mcg Natural Cherry Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this B-12 supplement work if I'm on metformin?
Metformin can interfere with how your body absorbs B-12 naturally, which is why supplementing may help. The interaction is Minor, and it's manageable — just make sure your doctor knows you're taking both so they can check your B-12 levels periodically.
Is this B-12 safe if I'm pregnant or breastfeeding?
Yes. B-12 is considered safe at recommended amounts during both pregnancy and breastfeeding — in fact, it's needed during these times. Follow your provider's guidance on dosing.
What is methylcobalamin, and why is it in this product?
Methylcobalamin is one form of vitamin B-12, the active form your body uses. It's chosen for supplements because it's thought to be readily absorbed and used by your body.
Can I overdose on B-12?
No. B-12 is water-soluble, so your body excretes any excess in your urine. There's no established upper limit for how much you can safely take.
Does this tablet have a lot of fillers?
This tablet does contain inactive ingredients like sorbitol, fructose, and mannitol (sweeteners and stabilizers) to bind and preserve it. If you prefer minimal additives, check the ingredient list to see if any concern you.
Are there any side effects?
B-12 taken by mouth is generally very well tolerated. A small number of people have reported allergic reactions like rash or itching, usually very rare. Serious side effects are uncommon.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Methyl B-12 1000 mcg Natural Cherry Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor label
Go deeper

The Full Monographs Behind Advanced Methyl B-12 1000 mcg Natural Cherry Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Advanced Methyl B-12 1000 mcg Natural Cherry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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