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Dietary supplement

Agmapure Unflavored Ingredients & Drug Interactions

by VMI Sports

Agmapure Unflavored label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmapure Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmapure Unflavored is a dietary supplement by VMI Sports with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are AgmaPure. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Agmapure Unflavored by VMI Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmapure Unflavored by VMI Sports — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agmapure Unflavored by VMI Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Agmapure Unflavored is a single-ingredient powder: agmatine, an amino acid compound derived from arginine. There are no other active ingredients.

The product contains no inactive fillers or binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: pre-workout support for physical activity.
  • We looked for evidence on: Athletic performance, Muscle strength, Exercise endurance, Workout performance.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence we hold shows insufficient reliable data to rate agmatine for any of the conditions it's marketed for — alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder. That doesn't mean it doesn't work; it means the research we've reviewed isn't conclusive enough yet to say either way.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated in people. The most common side effects reported in clinical trials are diarrhea, indigestion (dyspepsia), and nausea — and they tend to appear within the first few days and resolve once you stop taking it.

One small study found mild-to-moderate diarrhea and nausea in 3 out of 24 people taking 3.56 grams daily. Long-term safety in humans hasn't been well studied, so caution is warranted with extended use.

The safety data during pregnancy and breastfeeding is not sufficient, so it's best to avoid this product if you're pregnant or breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensives) and diabetes drugs (antidiabetes medications) before taking Agmapure. Both categories have documented Moderate-severity interactions with agmatine that could lower your blood pressure or blood sugar too far.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agmapure may be worth considering if you're researching agmatine for a specific condition, but the evidence in our data doesn't yet support its effectiveness for the uses listed. If you take blood pressure or diabetes medications, you must check your exact drugs with the tool on this page before starting.

Ask your pharmacist — especially if you're pregnant, breastfeeding, or planning long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmapure Unflavored, straight from the product label.

Brand VMI Sports
Barcode (UPC) 850748005184
Net contents 30 Gram(s); 1.05 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 295163
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmapure Unflavored by VMI Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
60
UPC/BARCODE
850748005184
IngredientAmount% DV
AgmaPure500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Consume 1 serving (1 scoop) in 6-8oz of water, or mix into your favorite pre-workout beverage, 20-30 minutes prior to weight training and/or physical activity. Do not consume more than three servings in any 24 hour period.

Choose your strength Improve Pumps 1x Maximum N.O. 2x Vein Splitting 3x

Precautions

Do not consume more than three servings in any 24 hour period. Warning: For use as a dietary supplement only, for healthy adults of the age of 18 and over.

Warning: For use as a dietary supplement only, for healthy adults of the age of 18 and over.

Do not use this product if you are pregnant, nursing, or may become pregnant. Do not consume if you have a pre-existing medical condition, or you are taking any prescription medication.

Please consult your doctor or health care practitioner prior to use. Do not use if safety seal is broken. Use only as directed and do not exceed recommended dosage.

Keep out of the reach of children.

Allergen Warning: Produced in a facility that may process ingredients containing milk, egg, soy, wheat, tree nuts, & peanuts.

Storage

Store in a cool, dry place (60 degrees F to 80 degrees F)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Follow us Facebook Twitter Instagram @vmisports

Seals/Symbols

VMI Sports is a USA Company

Formula

Pure Agmatine Sulfate

Agamapure Natural Agmatine Sulfate

Formulation

Enhance pumps & Endurance Supports Nitric Oxide Production Improved Vasodilation

All Natural

Artificial Free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

VMI Sports Vision Meets Innovation

Agmapure is a registered trademark of Shanghai Yongyi Biotechnology Co., LTD.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmapure Unflavored by VMI Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmapure Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmapure Unflavored by VMI Sports

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container60 Amounts shown are per serving.

AgmaPure

Interacts with
258 drugs
500 mg per serving Form: Agmatine Sulfate

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

AgmaPure monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmapure Unflavored by VMI Sports Drug Interactions

Want to check YOUR meds against Agmapure Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

AgmaPure 258

Individual Drug Interactions

The ingredients in Agmapure Unflavored interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmapure Unflavored interact with drugs. Each result below shows which ingredient is responsible. AgmaPure

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmapure Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

AgmaPure2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
AgmaPure full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmapure Unflavored, from the product label.

VMI Sports

See all VMI Sports products
Name
VMI Sports
Street Address
100 B Tec Street
City
Hicksville
State
NY
ZipCode
11801
Web Address
www.vmisports.com
Pharmacist Counseling Corner

Agmapure Unflavored by VMI Sports: Common Questions

Does Agmapure Unflavored by VMI Sports interact with any medications?
Yes. Based on its ingredients, Agmapure Unflavored has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmapure Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does agmatine do?
Agmatine is an amino acid compound that's being studied for several conditions — alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism, and bipolar disorder — but the evidence we have isn't strong enough yet to say whether it actually works for any of them.
Can I take this if I'm pregnant?
No, there isn't enough safety data on agmatine in pregnancy, so it's best to avoid it. Talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
The safety data for breastfeeding isn't sufficient, so it's best to avoid this product while nursing. Your doctor or pharmacist can give you personalized guidance.
What side effects should I watch for?
The most common ones reported in trials are diarrhea, indigestion, and nausea — usually showing up in the first few days and going away once you stop. If you notice anything unusual, stop taking it and check with your pharmacist.
Is it safe to take long-term?
Short-term use looks generally well tolerated, but how safe it is over the long haul in people hasn't been well studied. If you're thinking of using it regularly for months or longer, talk with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmapure Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmapure Unflavored label
Go deeper

The Full Monographs Behind Agmapure Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmapure Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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