Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Volcano Ingredients & Drug Interactions

by Force Factor

Volcano label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Volcano against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Volcano is a dietary supplement by Force Factor with 2 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 303 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Volcano by Force Factor

Ask about any prescription or over-the-counter medication and we check it for interactions with Volcano by Force Factor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Volcano by Force Factor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Vitamin B6” is listed as a grouped ingredient — the label gives one combined amount (1 mg) without saying how much of each component you get.
  • “Vein-Annihilating Energy Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Volcano contains 8 active ingredients designed to support muscle performance and blood flow. The formula includes L-Citrulline and agmatine, which work on nitric oxide pathways to promote vasodilation (widening of blood vessels); L-Methionine and L-Glycine, amino acids with various metabolic roles; two forms of creatine (CON-CRET Creatine HCl and Creatine Strength Complex) to support muscle strength and performance; and Vitamin B6, which is part of a blend.

The product also contains L-Norvaline and a Nitric Oxide Muscle Matrix, whose specific roles aren't detailed in our data. The capsule itself includes inactive ingredients like gelatin, silica, microcrystalline cellulose, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: energy, power, and strength for workouts.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle breakdown, Exercise performance, Muscle endurance, Workout recovery.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

The evidence for Volcano's ingredients is mixed. L-Citrulline shows possibly effective evidence for athletic performance, and both creatine forms are possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss).

L-Glycine is possibly effective for schizophrenia. However, L-Methionine shows insufficient evidence for most of its proposed uses — neural tube birth defect prevention is its only possibly effective claim.

Agmatine has insufficient evidence for all conditions listed in our data, from athletic performance to anxiety. The Nitric Oxide Muscle Matrix and L-Norvaline lack effectiveness ratings in our data.

The evidence, ingredient by ingredient Vitamin B6 Creatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine and L-Citrulline are generally well tolerated in healthy adults, though creatine can cause dehydration, diarrhea, muscle cramps, and water retention — those with kidney problems should be careful. L-Methionine is well tolerated at food amounts but high-dose supplements may cause dizziness, drowsiness, low blood pressure, headache, and increased homocysteine levels.

L-Glycine is generally well tolerated but may rarely cause mild sedation, insomnia, fatigue, or gastrointestinal upset. Agmatine appears well tolerated short-term but caused mild-to-moderate diarrhea and nausea in a small number of trial participants.

L-Norvaline and the Nitric Oxide Muscle Matrix lack safety data in our files.

Side effects, ingredient by ingredient Vitamin B6 Creatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Glycine, L-citrulline, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 265 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Volcano, check with your pharmacist if you use antihypertensive drugs (blood pressure medications), phosphodiesterase-5 inhibitors (sildenafil, tadalafil), antidiabetes drugs (Moderate interactions with L-Citrulline and agmatine), or clozapine (an antipsychotic — Moderate interaction with L-Glycine). No interactions are documented for L-Methionine or creatine in our data, but we could not check L-Norvaline or the Nitric Oxide Muscle Matrix.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Volcano is aimed at people looking to boost athletic performance and muscle strength, with creatine and citrulline as its most evidence-backed ingredients. If you take blood pressure or diabetes medications, or if you use erectile dysfunction medications, check your specific drugs with the tool before starting this product.

Those with kidney problems should talk to their pharmacist first, and it's not recommended during pregnancy or breastfeeding based on current safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Volcano, straight from the product label.

Brand Force Factor
Barcode (UPC) 818594012084
Net contents 144 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39443
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Volcano by Force Factor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
72
UPC/BARCODE
818594012084
IngredientAmount% DV
Vitamin B61 mg50%
L-Methionine0 NP--
L-Citrulline0 NP--
L-Glycine0 NP--
L-Norvaline0 NP--
CON-CRET Creatine HCl0 NP--
Nitric Oxide Muscle Matrix1520 mg--
Vein-Annihilating Energy Blend0 NP--
Agmaprue Agmatine Sulfate0 NP--
Creatine Strength Complex0 NP--

Other ingredients: Gelatin, Silica, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FD&C Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

UNLEASH THE FORCE At first glance, a volcano looks like nothing more than a harmless mountain. But deep inside, it's full of raging hot magma that's ready to erupt with destructive force.

It's an unassuming little capsule that can deliver the energy, power, and strength you need to destroy even your most punishing workouts. Like an oncoming tidal wave of lava, nothing will stand in your way when you're fueled by VolcaNO.

Pyro-Tectonic Power in the Palm of Your Hand You've undoubtedly heard of L-citrulline, creatine, and agmatine, but you've likely never seen all three in a single pre-workout supplement. That's because VolcaNO is one of the first if its kind--different from any formula ever developed. The unrelenting combination of red-hot muscle-building power ingredients is what sets VolcaNO apart from the competition.

As soon as you take VolcaNO, the rock-crushing blends get to work igniting the production of nitric oxide in your body. Like gasoline poured on a fire, L-citrulline is the primary catalyst for nitric oxide creation in VolcaNO. As your body produces more nitric oxide, your endurance will start to climb, and your strength and power will increase to help you blast through to your last rep.

Creatine delivers serious energy and power to help you get the results you want in the gym. It usually comes in bulky powders that require you to drink a lot of water right before your workout, but COn-CRET is ultra concentrated, finally making it possible to get the strength, endurance and muscle gains you're craving, without that sloshy, bloated feeling.

The benefits of VolcaNO boil down to a simple equation: smart science plus cataclysmic ingredients equal an unbeatable transformation in the gym. VolcaNO sets a new standard for pre-workout supplements. When you feel the raw power ready to erupt inside you, you'll understand why VolcaNO is the most intense nitric oxide booster you've ever tried.

20% FREE BONUS PACK!

EXPLOSIVE NITRIC OXIDE BOOSTER > Amplify Energy and Power > Boost Strength and Endurance > Improve Muscle Mass and Recovery

PRE-WORKOUT MUSCLE BUILDER

MADE IN THE USA

Brand IP Statement(s)

VolcaNO(TM) from Force Factor(R) is no different.

VOLCANO(TM) SCIENCE

Agmapure(TM) is a trademark of Shanghal Yongyl Biotechnology Co., Ltd. CON-CRET(R) and CON-CRET REINFORCED(R) are registered trademarks of ProMera Health, LLC. CON-CRET(R) is covered by one or more of U.S. Patent Nos. 8,354,450, 8,026,385, and 7,608,641.

Formula

The secret is three time-tested ingredients: L-citrulline, creatine, and agmatine. On their own, they're nothing special. But when fused together into one earth-shattering pre-workout formula, they unleash a monstrous volcaic fury that will help you finally build the rock-solid body you've been craving. VolcaNO is one of the first supplements ever to include this explosive triad, and once you experience the seismic power, you won't be able to imagine a workout without it.

The second core ingredient in VolcaNO is CON-CRET(R), a revolutionary form of creatine.

Rounding out the formula is agmatine. You've probably heard the buzz about agmatine, and for good reason. Naturally synthesized by your body, this super-ingredient is quickly becoming a key part of many weightlifters' routines.

Seals/Symbols

L-CITRULLINE + CREATINE AGMATINE

{facebook} {twitter} {Instagram} {YouTube}

Force Factor(R)

CON-CRET REINFORCED(R)

Suggested/Recommended/Usage/Directions

DIRECTIONS Workout Days: Take 2-4 capsules with breakfast and 2-4 capsules 30 minutes before working out. Rest Days: Take 2-4 capsules with breakfast and 2-4 capsules with dinner.

WORKOUT DAYS REST DAYS breakfast 30min. before your workout breakfast dinner {glass 2/4} {glass 2/4} {glass 2/4} {glass 2/4}

ENHANCE YOUR RESULTS WITH STACKING VolcaNO was engineered to deliver incredible muscle gains on it's own, but to take your workouts to another level, stack it with other premium Force Factor products. Burn fat and enhance performance by combining VolcaNO with Test X180 Ignite. Recover from your workouts with Force Factor's rejuvenating Performance Protein(TM). Find more stacking suggestions at www.ForceFactor.com.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Keep out of reach of children. For adult use only.

Allergen Warning: Manufactured by equipment which processes products containing milk, eggs, soybeans, wheat, shell fish, fish oil, tree nuts, and peanut flavor.

Precautions: Use only as directed.

Consult a healthcare professional before starting any new diet and exercise program, if you are pregnant or nursing, have a medical condition, or use prescription medications.

Storage

Store in a cool, dry place. Protect from heat, light, and moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, prevent, or cure any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Volcano by Force Factor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Volcano label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Volcano by Force Factor

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container72 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
1 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Nitric Oxide Muscle Matrix

1520 mg per serving

Other (inactive) ingredients: Gelatin, Silica, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Volcano by Force Factor Drug Interactions

Want to check YOUR meds against Volcano?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
303Drugs
298 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210

Individual Drug Interactions

The ingredients in Volcano interact with 303 drugs. Click any drug to see the details.

1 of the 2 ingredients in Volcano interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in Volcano with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Volcano, from the product label.

Force Factor

Name
Force Factor, LLC
City
Boston
State
MA
ZipCode
02108
Phone Number
1-866-443-6723
Pharmacist Counseling Corner

Volcano by Force Factor: Common Questions

Does Volcano by Force Factor interact with any medications?
Yes. Based on its ingredients, Volcano has a known interaction with 303 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Volcano contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Volcano if I'm pregnant or nursing?
The safety data advises against L-Citrulline and agmatine during pregnancy and breastfeeding due to insufficient evidence. L-Methionine is rated likely safe, but creatine, L-Glycine, and L-Norvaline have not been studied enough in pregnancy or breastfeeding. Talk with your doctor or pharmacist before use if you're pregnant or nursing.
What are the most common side effects?
Creatine may cause dehydration, diarrhea, muscle cramps, and water retention. L-Citrulline can cause gastrointestinal discomfort and heartburn. Agmatine has caused diarrhea, nausea, and indigestion in some trial participants. L-Methionine at high doses may cause dizziness, drowsiness, and headache.
Does Volcano actually help athletic performance?
L-Citrulline and both forms of creatine show possibly effective evidence for athletic performance in our data. Creatine also has possibly effective evidence for muscle strength. That said, these are individual ingredients — the combination's overall effect in Volcano hasn't been rated in our files.
Is creatine safe for my kidneys?
Creatine is generally well tolerated in healthy adults, but those with existing kidney issues should be careful — the safety notes flag kidney disease as a caution point. If you have any kidney problems, talk to your pharmacist or doctor before starting.
What is L-Citrulline supposed to do?
L-Citrulline is converted in your body to L-arginine, which increases nitric oxide and helps blood vessels relax and dilate. The data shows it's possibly effective for athletic performance, though its effects on cardiovascular disease and heart failure don't yet have enough evidence.
Will this product interact with my blood pressure medication?
Yes — L-Citrulline and agmatine both interact with antihypertensive drugs (Moderate severity), meaning they could work together and raise the risk of low blood pressure. Use the search tool on this page to check your specific medication before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Volcano is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Volcano label
Go deeper

The Full Monographs Behind Volcano’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph →
Sources

Sources & How We Checked

Volcano's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 146 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
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L-citrulline 8 references
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Glycine 5 references
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See these in context on the Glycine monograph →

Creatine 86 references
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Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
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