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Dietary supplement

Appebon Kid Syrup with Iron Ingredients & Drug Interactions

by UNILAB

Appebon Kid Syrup with Iron label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Appebon Kid Syrup with Iron against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Appebon Kid Syrup with Iron is a dietary supplement by UNILAB with 5 active ingredients. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 306 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pyridoxine Hydrochloride, Iron, Cyanocobalamin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Appebon Kid Syrup with Iron by UNILAB

Ask about any prescription or over-the-counter medication and we check it for interactions with Appebon Kid Syrup with Iron by UNILAB — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Appebon Kid Syrup with Iron by UNILAB

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Appebon Kid Syrup with Iron is a liquid formulation with five active ingredients: L-lysine hydrochloride (an amino acid), pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12), thiamine hydrochloride (vitamin B1), and iron. The B vitamins support energy metabolism and nervous system function; lysine is included for immune support; and iron helps build healthy red blood cells, especially important in children.

The product also contains inactive ingredients such as humectants, pH control agents, a thickener, sucralose for sweetness, preservatives, flavorings, color, a sequestrant, and purified water.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: help provide children nutrients for energy and appetite.
  • We looked for evidence on: Child development, Child growth, Fatigue, Pediatric nutritional support, Growth support.
  • The closest evidence on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Child growth (Natural Medicines).
  • Also on file: Iron is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Child development.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Child development.

Of the active ingredients, vitamin B6 is rated Effective for sideroblastic anemia and vitamin B6 deficiency, and Likely Effective for lowering homocysteine levels. Vitamin B12 is Effective for vitamin B12 deficiency and related conditions like Imerslund-Grasbeck disease.

Thiamine (vitamin B1) is Effective for thiamine deficiency and Wernicke-Korsakoff syndrome. Iron is Effective for iron deficiency anemia and Effective for anemia of chronic disease, and Possibly Effective for heart failure.

Lysine is Possibly Effective for cold sores but has Insufficient evidence for child growth, pressure ulcers, and diabetic foot ulcers. The evidence for this product's overall effectiveness in children depends on whether there is an actual deficiency of one or more of these nutrients—this is best assessed by your child's doctor.

The evidence, ingredient by ingredient Lysine Vitamin B6 Vitamin B12 Thiamine Iron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At typical doses, the ingredients in this product are generally well tolerated. Pyridoxine is safe at normal supplement amounts, but high doses over time can damage nerves; the product is intended for children, so standard pediatric dosing should be used.

Lysine may cause stomach upset, abdominal pain, or diarrhea at high amounts, and long-term safety in supplements has not been well studied. Vitamin B12 is very safe with no established upper limit because excess is excreted in urine.

Thiamine is generally very safe by mouth at normal amounts. Iron, at recommended doses, is well tolerated but can cause abdominal pain, constipation, diarrhea, nausea, or vomiting; excess iron is toxic and should be used only when there is a real need.

For pregnancy and breastfeeding, data varies by ingredient: vitamin B12 is Likely Safe in both; pyridoxine has mixed safety ratings and should be used only under doctor guidance if the mother is pregnant or nursing; lysine and thiamine safety data in these settings is limited and warrants provider consultation. Iron is considered Likely Safe in pregnancy when dosed by a prenatal provider, but safety during breastfeeding is less established.

Side effects, ingredient by ingredient Lysine Vitamin B6 Vitamin B12 Thiamine Iron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lysine, Iron, Vitamin B12, Vitamin B6, Thiamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 306 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product to your child, double-check with your pharmacist if they take quinolone or tetracycline antibiotics, levothyroxine (thyroid medication), bisphosphonates, methyldopa (blood pressure medication), levodopa (Parkinson's medication), antihypertensive drugs, amiodarone, phenobarbital or phenytoin (seizure medications), or mycophenolate mofetil. Iron in particular can significantly reduce how well these drugs are absorbed, and doses need to be spaced apart.

Metformin users should also be aware that vitamin B12 levels may be lower. If you're unsure, run the specific medication names through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be considered for children with documented vitamin B deficiencies, lysine needs, or iron deficiency anemia—but these should be confirmed by your child's doctor first. If your child takes any prescription medication, especially antibiotics, thyroid medication, seizure medication, or blood pressure medication, check with us before starting.

Talk to your pharmacist or pediatrician about whether this product is right for your child's specific needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Appebon Kid Syrup with Iron, straight from the product label.

Brand UNILAB
Net contents 0 NP
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 240353
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Children 4 or More Years of Age, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Appebon Kid Syrup with Iron by UNILAB, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mL
Maximum serving Sizes:
10 mL
IngredientAmount% DV
L-Lysine Hydrochloride125 mg--
Pyridoxine Hydrochloride0.6 mg100%
Cyanocobalamin1.2 mcg100%
Thiamine Hydrochloride0.6 mg100%
Iron9 mg100%

Other ingredients: Humectants, pH Control Agents, Thickener, Sucralose, Preservative, Flavor, Colour, Sequestrant, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Trusted Quality Healthcare

RENI, Recommended Energy and Nutrient Intake 2002 Reference Age: children 4-6 years old

Formula

Appebon Kid Syrup is a dietary supplement to help provide children with nutrients essential for energy and to help improve appetite. Appebon Kid Syrup uses the unique TasteRite technology of PediaTech that significantly improves the taste of vitamins and minerals. With Appebon giving your child's daily intake of vitamins has never been easier!

Suggested/Recommended/Usage/Directions

Suggested Use Age group Recommended Dose Orally, once a day. 2-6 years 5 mL (1 teaspoonful) 7-9 years 7.5 mL (1 1/2 teaspoonsful) 10-12 years 10 mL (2 teaspoonsful) Or, as directed by a doctor

Formulation

What is the product used for? Appebon Kid Syrup is a dietary supplement to help provide children with nutrients essential for energy and to help improve appetite.

Precautions

The contents of this site are for information purposes only and should not be construed as a substitute for professional medical advice. For diagnosis, treatment, and prescription, consult your physician and other healthcare providers. Carefully read all product labels and packaging prior to use.

Brand IP Statement(s)

2018. All Rights Reserved. UNILAB, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Appebon Kid Syrup with Iron by UNILAB label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Appebon Kid Syrup with Iron label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Appebon Kid Syrup with Iron by UNILAB

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 mL Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Lysine Hydrochloride

Interacts with
1 drug
125 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

Pyridoxine Hydrochloride

Interacts with
210 drugs
0.6 mg per serving Form: Vitamin B6

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Pyridoxine Hydrochloride monograph & interactions

Cyanocobalamin

Interacts with
20 drugs
1.2 mcg per serving Form: Vitamin B12

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Cyanocobalamin monograph & interactions

Thiamine Hydrochloride

Interacts with
3 drugs
0.6 mg per serving Form: Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine Hydrochloride monograph & interactions

Iron

Interacts with
80 drugs
9 mg per serving Form: Ferric Pyrophosphate

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Other (inactive) ingredients: Humectants, PH Control Agents, Thickener, Sucralose, Preservative, Flavor, Colour, Sequestrant, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Appebon Kid Syrup with Iron by UNILAB Drug Interactions

Want to check YOUR meds against Appebon Kid Syrup with Iron?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
306Drugs
281 Moderate 25 Minor

Ingredients driving the most interactions

Pyridoxine Hydrochloride 210
Iron 80
Cyanocobalamin 20
Thiamine Hydrochloride 3
L-Lysine Hydrochloride 1

Individual Drug Interactions

The ingredients in Appebon Kid Syrup with Iron interact with 306 drugs. Click any drug to see the details.

5 of the 5 ingredients in Appebon Kid Syrup with Iron interact with drugs. Each result below shows which ingredient is responsible. Pyridoxine Hydrochloride Iron Cyanocobalamin Thiamine Hydrochloride L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Appebon Kid Syrup with Iron with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pyridoxine Hydrochloride5 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Pyridoxine Hydrochloride full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions

Cyanocobalamin1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Cyanocobalamin full monograph & interactions

Thiamine Hydrochloride1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine Hydrochloride full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Appebon Kid Syrup with Iron, from the product label.

UNILAB

See all UNILAB products
Name
UNILAB
Street Address
66 United St.
City
Mandaluyong City
Pharmacist Counseling Corner

Appebon Kid Syrup with Iron by UNILAB: Common Questions

Does Appebon Kid Syrup with Iron by UNILAB interact with any medications?
Yes. Based on its ingredients, Appebon Kid Syrup with Iron has a known interaction with 306 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Appebon Kid Syrup with Iron contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it okay to give this to my child with their other medications?
It depends on what medications they take. Iron and several of the B vitamins can interfere with how certain drugs—like antibiotics, thyroid medication, and seizure medication—are absorbed. Use the interaction checker on this page with your child's exact medication list, and ask your pharmacist to be sure.
Can this cause stomach upset in kids?
Yes. Iron commonly causes abdominal pain, constipation, diarrhea, nausea, or vomiting. Lysine can also cause stomach upset and diarrhea at higher amounts. Start at the recommended dose for your child's age and watch for these side effects.
Does my child really need all five ingredients?
That's a question for your pediatrician. This product contains vitamin B1, B6, and B12, plus lysine and iron. Each is useful only if your child actually has a deficiency of that nutrient or meets a specific medical need. A blood test can help determine if supplementation is necessary.
What is lysine in this product for?
Lysine is an amino acid that's Possibly Effective for cold sores (herpes labialis). For other uses in children—like growth or wound healing—there isn't reliable evidence yet.
How much iron is safe for kids?
Iron is generally well tolerated at recommended doses for children, but the right amount depends on your child's age and whether they have an iron deficiency. Follow the label directions or ask your pediatrician; excess iron can be toxic, so don't exceed the recommended dose.
Can I give this while my child is breastfeeding or if I'm nursing?
Vitamin B12 is considered safe during breastfeeding at recommended amounts. For the other ingredients, data is more limited—check with your doctor or pharmacist for personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Appebon Kid Syrup with Iron label
Go deeper

The Full Monographs Behind Appebon Kid Syrup with Iron’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph →
Sources

Sources & How We Checked

Appebon Kid Syrup with Iron's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 148 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
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Vitamin B12 30 references
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See these in context on the Iron monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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