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Dietary supplement

Arjuna Bark Extract 500 mg Ingredients & Drug Interactions

by Pure Naturals Herbs

Arjuna Bark Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Arjuna Bark Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Arjuna Bark Extract 500 mg is a dietary supplement by Pure Naturals Herbs with 1 active ingredient. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 935 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Arjuna bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Arjuna Bark Extract 500 mg by Pure Naturals Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Arjuna Bark Extract 500 mg by Pure Naturals Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Arjuna Bark Extract 500 mg by Pure Naturals Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: arjuna bark extract, 500 mg per capsule. Arjuna is a traditional herb that's been studied for heart and circulation health.

The capsule also holds three inactive ingredients — cellulose, silicon dioxide, and magnesium stearate — which are common fillers and binders used to form and stabilize the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Terminalia product and its label doesn't state a use — see Terminalia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for arjuna bark extract's effectiveness isn't established in our data. We hold insufficient reliable evidence to rate it for obesity, high cholesterol (hyperlipidemia), high blood pressure (hypertension), or angina.

That doesn't mean it doesn't work — it means the research we have isn't strong enough yet to say either way. If you're considering it for any of these purposes, talk with your doctor or pharmacist about whether the available evidence makes sense for your situation.

The evidence, ingredient by ingredient Terminalia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Arjuna bark extract is generally well tolerated in short-term studies, but long-term safety information is limited and quality varies between products. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in those situations.

If you're pregnant, planning to become pregnant, or nursing, skip this supplement and talk with your doctor about your options.

Side effects, ingredient by ingredient Terminalia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Terminalia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 936 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications against these types. Worst first: any drug metabolized by CYP2D6, CYP2C9, or CYP3A4 enzymes (a very large group covering many heart, blood pressure, antidepressant, and other medications) — Moderate severity.

Blood thinners and antiplatelet drugs — Moderate severity. Diabetes medications — Moderate severity.

Chlorzoxazone (a muscle relaxer) and omeprazole (heartburn medication) — Moderate severity. Use the interaction checker below with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Arjuna bark extract is best suited for someone without major drug-drug interactions and who's looked up their specific medications first. If you take any prescription drugs — especially blood thinners, diabetes medications, muscle relaxers, heartburn medications, or anything metabolized by your liver — check with your pharmacist before starting.

Pregnant or breastfeeding? This isn't the right choice.

Talk to your pharmacist about whether arjuna fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Arjuna Bark Extract 500 mg, straight from the product label.

Brand Pure Naturals Herbs
Barcode (UPC) 816511024868
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 323833
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Arjuna Bark Extract 500 mg by Pure Naturals Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
120
UPC/BARCODE
816511024868
IngredientAmount% DV
Arjuna bark extract500 mg--

Other ingredients: Cellulose, Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) veggie capsule daily, preferably with a meal or as directed by a health care professional.

Precautions

Caution: For adults only.

If you are pregnant, nursing, taking any medication(s) or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Standardized to 25% tannins Antioxidant properties helps prevent free radical damage Supports healthy lipid levels Promotes heart health

Contains no: Preservatives, artificial colors, flavors or sweeteners, sugar, starch, milk, lactose, gluten, wheat, yeast, fish or sodium.

An FDA regulated facility

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Arjuna Bark Extract 500 mg by Pure Naturals Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Arjuna Bark Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Arjuna Bark Extract 500 mg by Pure Naturals Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Arjuna bark extract

Interacts with
935 drugs
500 mg per serving Form: Tannins

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....

Arjuna bark extract monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Arjuna Bark Extract 500 mg by Pure Naturals Herbs Drug Interactions

Want to check YOUR meds against Arjuna Bark Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
935Drugs
935 Moderate

Ingredients driving the most interactions

Arjuna bark extract 935

Individual Drug Interactions

The ingredients in Arjuna Bark Extract 500 mg interact with 935 drugs. Click any drug to see the details.

1 of the 1 ingredient in Arjuna Bark Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Arjuna bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Arjuna Bark Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Arjuna bark extract7 drug types · 935 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.

Likelihood Possible Evidence D
Arjuna bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Arjuna Bark Extract 500 mg, from the product label.

Pure Naturals Herbs

See all Pure Naturals Herbs products
Name
Pure Naturals Herbs
City
Jersey City
State
NJ
Web Address
purenaturals.co
Pharmacist Counseling Corner

Arjuna Bark Extract 500 mg by Pure Naturals Herbs: Common Questions

Does Arjuna Bark Extract 500 mg by Pure Naturals Herbs interact with any medications?
Yes. Based on its ingredients, Arjuna Bark Extract 500 mg has a known interaction with 935 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Arjuna Bark Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is arjuna bark extract supposed to do?
Arjuna has been used traditionally for heart and circulation health. The evidence we have isn't strong enough yet to confirm it works for obesity, high cholesterol, high blood pressure, or angina — so we can't say it does or doesn't based on current data.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety information, and the data advises against it. If you're pregnant, trying to become pregnant, or nursing, talk with your doctor about safer options.
Are there any side effects I should know about?
No adverse effects are listed in our data for arjuna bark extract, though long-term safety information is limited. That said, because it may interact with many medications and raise their levels, side effects could come from your drugs being stronger than expected — which is why checking your medications first is important.
Does this product have any fillers or other ingredients?
Yes — along with the 500 mg of arjuna bark extract, the capsule contains cellulose, silicon dioxide, and magnesium stearate, which are inactive ingredients used to make and stabilize the capsule.
How long can I take this safely?
Short-term use is generally well tolerated in studies, but we don't have solid long-term safety data, and quality varies between products. Talk with your pharmacist about how long to take it and which brand might be most reliable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Arjuna Bark Extract 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Arjuna Bark Extract 500 mg label
Go deeper

The Full Monographs Behind Arjuna Bark Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Terminalia

Interacts with 935 drugs

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...

Read the full Terminalia monograph →
Sources

Sources & How We Checked

Arjuna Bark Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Terminalia 9 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
  3. Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
  4. Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
  5. Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
  6. Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
  7. Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
  8. Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
  9. Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed

See these in context on the Terminalia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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