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Dietary supplement

Artemisia Annua Ingredients & Drug Interactions

by Samsara Herbs

Artemisia Annua label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artemisia Annua against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artemisia Annua is a dietary supplement by Samsara Herbs with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artemisia annua. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artemisia Annua by Samsara Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Artemisia Annua by Samsara Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artemisia Annua by Samsara Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a powder containing one active ingredient: artemisia annua, also called sweet annie. The plant has been used traditionally in herbal medicine, and the supplement form contains no inactive fillers or binding agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy blood and allergy response.
  • We looked for evidence on: Allergic rhinitis (hay fever).
  • The strongest evidence on file: Sweet Annie is rated "Possibly Effective" for Allergic rhinitis (hay fever) (Natural Medicines).

The evidence for sweet annie is limited. It's rated possibly effective for hay fever (allergic rhinitis), though the data isn't robust.

For nonalcoholic fatty liver disease, malaria, and osteoarthritis, we don't hold enough reliable evidence to say whether it works. If you're considering this for hay fever, talk with your doctor about how it compares to proven treatments.

The evidence, ingredient by ingredient Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, sweet annie is generally well tolerated, but nausea and vomiting are the most common side effects. Rarely, it may cause liver damage — one reported case involved hepatitis after taking a high dose of the isolated compound for 10 days, though it's unclear whether the supplement was solely responsible.

A mild allergic reaction (rash and cough) has been reported once, and people allergic to sweet annie who take it under the tongue may experience numbness or throat itching. The product is meant for short-term use, and quality and dose vary widely between brands, so it shouldn't replace proven treatments for any condition.

Side effects, ingredient by ingredient Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check any medications that are broken down by your liver's CYP3A4 or CYP2B6 enzymes — sweet annie may change how well they work. Also mention any drugs that can damage your liver (hepatotoxic medications), since sweet annie carries a small liver-injury risk on its own.

Use the interaction checker on this page with your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sweet annie is generally tolerated when used short-term, but it interacts with a large number of medications through multiple liver pathways, and there's a rare risk of liver damage. If you take any prescription drugs or over-the-counter medications regularly, you need to check them against the interaction tool before starting.

It's not safe in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artemisia Annua, straight from the product label.

Brand Samsara Herbs
Barcode (UPC) X001SMWJY5
Net contents 4 oz; 114 Gram(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255328
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artemisia Annua by Samsara Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Scoop(s)
Maximum serving Sizes:
1 Scoop(s)
Servings per container
196
UPC/BARCODE
X001SMWJY5
IngredientAmount% DV
Artemisia annua580 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Standardized

Standardized herbal extracts contain isolated herbal compounds, in guaranteed amounts. Often having the prevalent compound found in an herb, in a significantly higher concentration than found in nature.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice

Brand IP Statement(s)

3rd party USA tested USA tested

General Statements

About Us At Samsara Herbs, we believe that all positive change in the world must first begin with positive change from within. We invite you to tap into your own infinite power through the use of our potent herbal extracts! We seek out only quality herbs from our trusted sources from around the world for use in our herbal extracts. Samsara Herbs, dedicated to empowering your life force!

Formula

Description Also known as sweet wormwood, Artemisia Annua has a long history of use in traditional Chinese medicine. In Eastern tradition, they believe it to regulate healthy blood as well as healthy allergy response. It is suggest it is used to promote normal digestion, menstruation, and liver function. Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

(98% Artemisinin)

Storage

Storage Cool dry place, out of direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 scoop per day or as recommended by your health care professional.

Precautions

Caution: If you have a medical condition, are pregnant or taking medications, consult your health care professional before using this product.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artemisia Annua by Samsara Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artemisia Annua label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artemisia Annua by Samsara Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Scoop(s) Dosage formPowder Servings per container196 Amounts shown are per serving.

Artemisia annua

Interacts with
889 drugs
580 mg per serving Form: Artemisinin

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...

Artemisia annua monograph & interactions
Interaction report

Artemisia Annua by Samsara Herbs Drug Interactions

Want to check YOUR meds against Artemisia Annua?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Artemisia annua 889

Individual Drug Interactions

The ingredients in Artemisia Annua interact with 889 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artemisia Annua interact with drugs. Each result below shows which ingredient is responsible. Artemisia annua

Each ingredient & the kinds of drugs it affects

For each ingredient in Artemisia Annua with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artemisia annua3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Artemisia annua full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artemisia Annua, from the product label.

Samsara Herbs

See all Samsara Herbs products
Name
Samsara Herbs Inc. by Aspen Copacking
Street Address
810 North 2800 West
City
Lindon
State
Utah
ZipCode
84042
Phone Number
1-844-972-6727
Web Address
www.SamaraHerbs.com
Pharmacist Counseling Corner

Artemisia Annua by Samsara Herbs: Common Questions

Does Artemisia Annua by Samsara Herbs interact with any medications?
Yes. Based on its ingredients, Artemisia Annua has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artemisia Annua contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is artemisia annua (sweet annie) used for?
Sweet annie is possibly effective for hay fever. For malaria, fatty liver disease, and osteoarthritis, we don't have enough reliable evidence to say whether it helps. Always talk with your doctor about whether a supplement is right for your situation instead of relying on it alone.
What are the most common side effects?
When taken by mouth, nausea and vomiting are the most common side effects. Rarely, it may cause liver damage. A mild allergic reaction with rash and cough has been reported once.
Is it safe to take during pregnancy or while breastfeeding?
No. The safety data advises against it during pregnancy because of possible harm to your baby. There's not enough safety information while breastfeeding, so you should avoid it then too. Talk with your doctor if you're pregnant, planning to become pregnant, or nursing.
How long can I safely take this supplement?
Sweet annie is generally used short-term. Quality and dose vary widely between products, so don't use it as a replacement for proven treatments. Talk with your pharmacist about how long is appropriate for you.
Does this product contain fillers or other inactive ingredients?
No. This product is a pure powder of artemisia annua with no added fillers or inactive ingredients.
Why do I need to check my medications against this product?
Sweet annie can change how your liver breaks down many common drugs, potentially making them less effective or causing them to build up in your body. It can also add to liver damage risk if you're taking other drugs that are tough on your liver. That's why you need to check your exact medications first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artemisia Annua is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artemisia Annua label
Go deeper

The Full Monographs Behind Artemisia Annua’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

Artemisia Annua's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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