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Dietary supplement

Pyloricom Ingredients & Drug Interactions

by Energique

Pyloricom label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pyloricom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pyloricom is a dietary supplement by Energique with 6 active ingredients. Its ingredients are commonly taken for cough and respiratory congestion, sore throat, digestive upset.Based on those ingredients, 1,327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove, Sweet Wormwood, Uva-ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pyloricom by Energique

Ask about any prescription or over-the-counter medication and we check it for interactions with Pyloricom by Energique — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pyloricom by Energique

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.50 mL) without saying how much of each component you get.

Pyloricom contains six active ingredients: Thyme, Sweet Wormwood, Uva-ursi, Black Walnut, Cassia, and Clove, delivered in a liquid form with purified water and ethanol as inactive ingredients. Thyme is traditionally used for respiratory health; Sweet Wormwood has been studied for allergic rhinitis and other conditions; Uva-ursi is a urinary tract herb; Black Walnut is included for its traditional uses; Cassia is a type of cinnamon; and Clove has been researched for ventilator-associated pneumonia and other applications.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Ventilator-associated pneumonia (VAP) — rated "Possibly Effective" (Clove) (Natural Medicines).
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Sweet Annie) (Natural Medicines).

The evidence backing these ingredients is thin. Sweet Wormwood rates as possibly effective for allergic rhinitis (hay fever), and clove is possibly effective for ventilator-associated pneumonia in hospitalized patients on mechanical ventilation.

For everything else in this product — thyme for bronchitis, aging skin, or alopecia; uva-ursi for urinary tract infections; black walnut for heart disease or wound healing; and cassia for diabetes, cholesterol, or cold symptoms — the evidence we hold is insufficient to say whether they work. Clove's effectiveness for cough, pain, or digestion also isn't established in our data.

The evidence, ingredient by ingredient Thyme Sweet Annie Uva Ursi Black Walnut Cassia Cinnamon Clove

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thyme is generally well tolerated orally and topically when used in food or medicinal amounts, though concentrated essential oil can be toxic if swallowed. The most common side effects are allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting.

Sweet Wormwood is generally well tolerated at low doses but poses rare serious risk — hepatotoxicity (liver damage) has been reported, and there's concern about its liver effects. Uva-ursi is well tolerated short-term at low doses but can be toxic at high doses; doses around 20 grams or higher may cause convulsions, delirium, and other severe effects, and 30 grams or more may be fatal.

Black Walnut nut is well tolerated, but the leaf, bark, and hull contain tannins that may cause gastrointestinal upset and skin irritation; tree nuts are a major allergen. Cassia is generally safe in food amounts, though large doses long-term raise liver concerns because of its coumarin content; one person taking 1 gram daily had a hypoglycemic seizure.

Clove is safe as a spice but concentrated clove oil is toxic in children at doses of only 5–10 mL; oral clove can rarely cause liver failure.

Side effects, ingredient by ingredient Thyme Sweet Annie Uva Ursi Black Walnut Cassia Cinnamon Clove

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Clove, Uva Ursi, Sweet Annie, Thyme, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,328 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take antidiabetes drugs (clove, cassia), anticoagulants or blood thinners (thyme, clove), liver-metabolized medications especially those using CYP3A4, CYP2D6, CYP2B6, CYP2C19, or CYP1A2 pathways (sweet wormwood, uva-ursi, clove), drugs that stress the liver (sweet wormwood, cassia), anticholinergic drugs (thyme), lithium (uva-ursi), or ibuprofen (clove). No interactions are documented for black walnut in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a blend of traditional herbs with minimal solid evidence of effectiveness. If you take any prescription medications — especially diabetes drugs, blood thinners, liver-metabolized drugs, or lithium — run them through the interaction checker on this page before you start.

Pregnant or breastfeeding women should talk to their pharmacist or doctor first, particularly about Sweet Wormwood and Uva-ursi. If you have a tree nut allergy, the black walnut content is a concern.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pyloricom, straight from the product label.

Brand Energique
Net contents 2 Fluid Ounce(s); 59 Milliliter(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 318462
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pyloricom by Energique, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Milliliter(s)
Maximum serving Sizes:
1.5 Milliliter(s)
Servings per container
39
IngredientAmount% DV
Proprietary Blend1.5 mL--
Thyme0 NP--
Sweet Wormwood0 NP--
Uva-ursi0 NP--
Black Walnut0 NP--
Cassia0 NP--
Clove0 NP--

Other ingredients: Water, Purified, Ethanol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warnings: If pregnant or breast-feeding, ask a health professional before use.

Consult a physician for use in children under 12 years of age. Keep out of reach of children.

Do not use if tamper evident seal is broken or missing.

Contains Black Walnut.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: 30 drops in water or juice 3 times daily or as otherwise directed. Shake well before use.

Formulation

Organic and wild-crafted herbs used when possible.

Brand IP Statement(s)

Energique Since 1987

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pyloricom by Energique label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pyloricom label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pyloricom by Energique

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.5 Milliliter(s) Dosage formLiquid Servings per container39 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1.5 mL per serving

Other (inactive) ingredients: Water, Purified, Ethanol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pyloricom by Energique Drug Interactions

Want to check YOUR meds against Pyloricom?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,327Drugs
1,291 Moderate 36 Minor

Ingredients driving the most interactions

Clove 977
Sweet Wormwood 889
Uva-ursi 803
Cassia 442
Thyme 379

Individual Drug Interactions

The ingredients in Pyloricom interact with 1,327 drugs. Click any drug to see the details.

5 of the 6 ingredients in Pyloricom interact with drugs. Each result below shows which ingredient is responsible. Clove Sweet Wormwood Uva-ursi Cassia Thyme

Each ingredient & the kinds of drugs it affects

For each ingredient in Pyloricom with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove full monograph & interactions

Sweet Wormwood3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Sweet Wormwood full monograph & interactions

Uva-ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva-ursi full monograph & interactions

Cassia2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cassia full monograph & interactions

Thyme4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pyloricom, from the product label.

Energique

See all Energique products
Name
Energique, Inc.
Street Address
201 Apple Blvd.
City
Woodbine
State
IA
ZipCode
51579
Phone Number
800.869.8078
Pharmacist Counseling Corner

Pyloricom by Energique: Common Questions

Does Pyloricom by Energique interact with any medications?
Yes. Based on its ingredients, Pyloricom has a known interaction with 1,327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pyloricom contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pyloricom if I'm pregnant?
Not without talking to your doctor first. Sweet Wormwood and Uva-ursi should be avoided in pregnancy. Thyme, Black Walnut, Cassia, and Clove are rated likely safe, but because this is a combination product and pregnancy safety is individual, it's best to get personalized advice from your pharmacist or doctor before starting.
Is this product safe if I'm breastfeeding?
Sweet Wormwood and Uva-ursi should be avoided while breastfeeding due to insufficient safety data. The other ingredients may be acceptable, but talk with your pharmacist or doctor before use — breastfeeding safety for combination products is best assessed one-on-one.
What is Sweet Wormwood in this supplement used for?
Sweet Wormwood is possibly effective for allergic rhinitis (hay fever). For other uses in this product, the evidence isn't established in our data. However, be aware that Sweet Wormwood can rarely cause liver damage, so it's important to check with your healthcare provider about its safety for your situation.
Will this product help with a urinary tract infection?
Uva-ursi is traditionally used for urinary tract health, but our data shows it's possibly ineffective for urinary tract infections. The evidence doesn't support its use for that purpose.
Can I take this if I'm allergic to tree nuts?
This product contains Black Walnut, which is a tree nut and a major food allergen. If you have a tree nut allergy, you should avoid this product and talk to your pharmacist or doctor about alternatives.
What are the most common side effects I might experience?
The most likely side effects come from Thyme (allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, vomiting), Uva-ursi (diarrhea, nausea, stomach upset, vomiting), and Black Walnut's tannin-containing parts (gastrointestinal upset). Clove topically can cause burning and contact dermatitis. Most people tolerate these ingredients well at normal doses, but if you experience any of these, stop and call your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pyloricom label
Go deeper

The Full Monographs Behind Pyloricom’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph → Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph →
Sources

Sources & How We Checked

Pyloricom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thyme 18 references
  1. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Okazaki K, Kawazoe K, Takaishi Y. Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 2002;16:398-9. .
  4. Spiewak R, Skorska C, Dutkiewicz J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001;44:235-9. . PubMed
  5. Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
  6. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  7. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  8. Mackiewicz, B., Skorska, C., Dutkiewicz, J., Michnar, M., Milanowski, J., Prazmo, Z., Krysinska-Traczyk, E., and Cisak, E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med 1999;6(2):167-170.
  9. Martinez-Gonzalez, M. C., Goday Bujan, J. J., Martinez, Gomez W., and Fonseca, Capdevila E. Concomitant allergic contact dermatitis due to Rosmarinus officinalis (rosemary) and Thymus vulgaris (thyme). Contact Dermatitis 2007;56(1):49-50.
  10. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.
  11. Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
  12. Cuzzolin, L. and Benoni, G. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study. Phytother.Res 2009;23(7):1018-1023. PubMed
  13. Berova, N., Stransky, L., and Krasteva, M. Studies on contact dermatitis in stomatological staff. Dermatol.Monatsschr. 1990;176(1):15-18.
  14. Smeenk, G., Kerckhoffs, H. P., and Schreurs, P. H. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br.J Dermatol. 1987;116(2):223-231.
  15. Le Roy, R., Grosshans, E., and Foussereau, J. [Investigation of contact allergies in 100 cases of ulcus cruris (author's transl)]. Derm.Beruf.Umwelt. 1981;29(6):168-170.
  16. Lorenzi, S., Placucci, F., Vincenzi, C., Bardazzi, F., and Tosti, A. Allergic contact dermatitis due to thymol. Contact Dermatitis 1995;33(6):439-440. PubMed
  17. Bahadoran P, Rokni FK, Fahami F. Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis. Iran J Nurs Midwifery Res 2010;15(Suppl 1):343-9.
  18. Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed

See these in context on the Thyme monograph →

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
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Uva Ursi 8 references
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Black Walnut 3 references
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Clove 26 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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