Ashwagandha 600 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ashwagandha 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha 600 mg is a dietary supplement by GNC Herbal Plus with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha 600 mg by GNC Herbal Plus
Ask about any prescription or over-the-counter medication and we check it for interactions with Ashwagandha 600 mg by GNC Herbal Plus — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Ashwagandha 600 mg by GNC Herbal Plus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: ashwagandha root extract at 600 mg per capsule. Ashwagandha is an herbal extract traditionally used to help manage stress, anxiety, and sleep.
The capsule also contains inactive ingredients — cellulose and titanium dioxide — which serve as the capsule material and filler.
Does it work?
Moderate evidence
Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder based on the evidence we hold. For bipolar disorder, the evidence isn't established well enough to rate it.
If you're considering it for one of those conditions, talk it over with your doctor or pharmacist to see if it's a fit for you.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated short-term in healthy adults, though quality and long-term safety data are limited. The most common side effects — diarrhea, gastrointestinal upset, nausea, and vomiting — don't usually occur at typical doses.
Rare but serious cases of liver damage and acute liver failure have been reported. Drowsiness can also occur.
The safety data advises against taking ashwagandha during pregnancy because of a traditional concern about miscarriage risk. There isn't enough safety information to recommend it while breastfeeding either.
If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before considering this product.
Meds to double-check
Moderate interaction found
Before taking this ashwagandha product, check with your doctor or pharmacist if you take any hepatotoxic drugs (medications that can stress your liver), CNS depressants or benzodiazepines (sedatives, sleeping pills, anxiety medications), antihypertensive drugs (blood pressure medications), antidiabetes drugs (blood sugar medications), thyroid hormone, or immunosuppressants. Altogether, these interactions span 1,373 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
GNC Herbal Plus Ashwagandha 600 mg is possibly effective for insomnia, anxiety, and stress in people without the medications listed above. If you take blood pressure drugs, diabetes medications, sleeping pills, anti-anxiety drugs, thyroid hormone, immunosuppressants, or any liver-stressing medication, you should check with your own doctor or pharmacist before starting this.
If you're pregnant or breastfeeding, don't use it without talking to your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha 600 mg, straight from the product label.
| Brand | GNC Herbal Plus |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 316434 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha 600 mg by GNC Herbal Plus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha Root Extract | 600 mg | -- |
Other ingredients: Cellulose, Cellulose, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Clinical strength
Vegetarian herbal extract
No artificial flavors, gluten free. GF Gluten free
FDA Statement of Identity
Herbal Supplement
Formula
Ashwagandha 600 mg per 2 capsules Contains KSM-66
KSM-66 Ashwagandha Ashwagandha as KSM-66.
General Statements
30-day supply
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take two capsules daily.
Precautions
Contains: Milk.
Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.
Discontinue use two weeks prior to surgery.
Brand IP Statement(s)
KSM-66 is a registered trademark of Ixoreal Biomed Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha 600 mg by GNC Herbal Plus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha 600 mg by GNC Herbal Plus
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container600 Amounts shown are per serving.
Ashwagandha Root Extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha Root Extract monograph & interactionsOther (inactive) ingredients: Cellulose, Cellulose, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
Ashwagandha 600 mg by GNC Herbal Plus Drug Interactions
HelloPharmacist Interaction Report
GNC Herbal Plus Ashwagandha 600 mg interacts with ashwagandha's ashwagandha root extract content across a range of medication types.
The most serious concern is with hepatotoxic drugs (liver-damaging medications) — ashwagandha has been linked to cases of acute liver damage, liver failure, and in rare instances death from liver failure, and using it alongside other drugs that stress the liver could compound that risk.
Read the full breakdown — every affected drug type, severity by severity
Ashwagandha also carries Moderate-severity interactions with CNS depressants (sedatives, sleeping pills, anxiety medications), benzodiazepines, antihypertensive drugs (blood pressure medications), antidiabetes drugs (blood sugar medications), thyroid hormone, and immunosuppressants. It may boost the sedative effects of sleeping pills and anti-anxiety drugs, lower your blood pressure further, increase the risk of low blood sugar, heighten thyroid hormone effects, or blunt the intended effects of drugs that suppress your immune system.
There's also a Minor interaction with CYP1A2 substrates — a set of medications your liver metabolizes in a particular way. Ashwagandha may reduce how well these drugs work by speeding up how your body clears them.
Additionally, use the medication search tool below to check your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha 600 mg interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha 600 mg interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract
Desiccated Thyroid ExtractWesthroid, WP Thyroid
How Desiccated Thyroid Extract interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Ashwagandha Root Extract + Desiccated Thyroid Extract interactionDesiccated Thyroid Extract (prescription Drug)Nature-Throid, Thyrar
How Desiccated Thyroid Extract (prescription Drug) interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Ashwagandha Root Extract + Desiccated Thyroid Extract (prescription Drug) interactionDesipramineDesipramine, Norpramin, Pertofrane
How Desipramine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Desipramine interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Desogestrel, Ethinyl Estradiol interactionDeucravacitinibSotyktu
How Deucravacitinib interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Deucravacitinib interactionDeutetrabenazineAustedo
How Deutetrabenazine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Deutetrabenazine interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Immunosuppressants Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Dexamethasone interactionDexmedetomidineIgalmi, Precedex
How Dexmedetomidine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Dexmedetomidine interactionDextrothyroxineCholoxin
How Dextrothyroxine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Ashwagandha Root Extract + Dextrothyroxine interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractBenzodiazepines, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
Read the full Ashwagandha Root Extract + Diazepam interactionDiclofenacZorvolex
How Diclofenac interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diclofenac Epolamine interactionDicyclomine, PhenobarbitalBentyl w/ Pb
How Dicyclomine, Phenobarbital interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Dicyclomine, Phenobarbital interactionDiethylstilbestrol, MethyltestosteroneTylosterone
How Diethylstilbestrol, Methyltestosterone interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Diethylstilbestrol, Methyltestosterone interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root Extract + Diltiazem, Enalapril interactionDiphenhydramineAllerdryl, Benadryl, Benadryl cream, Benadryl spray, Compoz, Dermamycin cream +9 more
How Diphenhydramine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Diphenhydramine interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDiphenhydramine, PseudoephedrineActifed Allergy
How Diphenhydramine, Pseudoephedrine interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Diphenhydramine, Pseudoephedrine interactionDiroximel FumarateVumerity
How Diroximel Fumarate interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Diroximel Fumarate interactionDivalproex SodiumDepakote
How Divalproex Sodium interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Divalproex Sodium interactionDolutegravir, Emtricitabine, Tenofovir AlafenamideDolutegravir, Emtricitabine, Tenofovir Alafenamide
How Dolutegravir, Emtricitabine, Tenofovir Alafenamide interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Dolutegravir, Emtricitabine, Tenofovir Alafenamide interactionDoxazosin MesylateCardura
How Doxazosin Mesylate interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root Extract + Doxazosin Mesylate interactionDoxepinDoxepin, Sinequan, Zonalon
How Doxepin interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract + Doxepin interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Ashwagandha 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycycline Monohydrate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha Root Extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha 600 mg, from the product label.
GNC Herbal Plus
See all GNC Herbal Plus products- Name
- GNC Holdings, LLC
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
Ashwagandha 600 mg by GNC Herbal Plus: Common Questions
Does Ashwagandha 600 mg by GNC Herbal Plus interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take ashwagandha if I'm pregnant or breastfeeding?
What are the most common side effects?
Does ashwagandha actually help with anxiety and sleep?
Will ashwagandha make me drowsy during the day?
How long can I safely take ashwagandha?
Is ashwagandha safe for my liver?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
- Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
- Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
- Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
- Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
- Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
- Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
- Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
- Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
- Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
- Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
- Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
- Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
- Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
- Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
- Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
- Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
- Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
- Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
- Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC