Ashwagandha Extract 600 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ashwagandha Extract 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha Extract 600 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,373 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha Extract 600 mg by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Ashwagandha Extract 600 mg by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ashwagandha Extract 600 mg by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains one active ingredient, ashwagandha root extract, at 600 mg. Its listed roles in our data are the sedative effects and the research into sleep, anxiety, and stress.
The inactive ingredients are dextrin and hypromellose, which are non-active materials used in the capsule and its makeup.
Does it work?
Moderate evidence
Our data rates ashwagandha as possibly effective for insomnia, generalized anxiety disorder (GAD), and stress. For attention deficit-hyperactivity disorder (ADHD), the evidence is rated insufficient reliable evidence to rate, so we cannot say whether it helps.
How safe is it?
Well-documented data
Ashwagandha is rated caution: it is generally well tolerated short-term in healthy adults, but quality and long-term safety data are limited. The most common side effects are diarrhea, stomach upset, nausea, and vomiting, which the data says do not commonly occur at typical doses.
Rare serious effects include liver concerns such as acute hepatitis and liver failure. A case report describes hyperthyroidism (an overactive thyroid) in a 73-year-old who took it alongside levothyroxine, and it resolved after stopping.
Drowsiness has also been reported. In pregnancy, the rating is likely unsafe, and the safety data advises against using it.
For breastfeeding, our safety notes say there is not enough safety information, so avoid it while breastfeeding.
Meds to double-check
Moderate interaction found
Double-check sedatives and CNS depressants, antihypertensives, benzodiazepines, antidiabetes drugs, thyroid hormone, hepatotoxic drugs, and immunosuppressants, all rated Moderate. Also check CYP1A2 substrates, rated Minor.
Ask your own doctor or pharmacist before combining this product with any of these medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha may be worth discussing if you are looking into support for stress, sleep, or anxiety and are not pregnant or breastfeeding. If you take sedatives, blood pressure medicine, diabetes medicine, thyroid hormone, or any medication that affects the liver, be especially careful.
Talk it over with your own doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha Extract 600 mg, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X003FE9HM1 |
| Net contents | 240 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 329917 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha Extract 600 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha Root Extract | 600 mg | -- |
Other ingredients: Dextrin, Hypromellose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Ashwagandha Extract 600 mg per serving
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1 capsule once daily, or as directed by a physician.
Formulation
Free of: Added sugar, dairy, yeast, soy, gluten
General Statements
Scan Me
New
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha Extract 600 mg by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha Extract 600 mg by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.
Ashwagandha Root Extract
Interacts with1,373 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha Root Extract monograph & interactionsOther (inactive) ingredients: Dextrin, Hypromellose. These complete the product’s ingredient list but are not active constituents.
Ashwagandha Extract 600 mg by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Ashwagandha Extract 600 mg from BulkSupplements.com interacts with several types of medication through its ashwagandha root extract.
The most serious documented concern is with CNS depressants (drugs that slow the brain and nervous system), rated Moderate. Theoretically, ashwagandha may increase the sedative effects of barbiturates, other sedatives, and anxiolytics (anti-anxiety drugs).
Read the full breakdown — every affected drug type, severity by severity
The other documented drug types are also rated Moderate, except one. Antihypertensive drugs (blood pressure medicines) may add to the risk of hypotension (low blood pressure).
Benzodiazepines may increase sedation, with preliminary evidence involving diazepam and clonazepam. Antidiabetes drugs may increase the risk of hypoglycemia (low blood sugar), and thyroid hormone may increase both its effects and its side effects.
Hepatotoxic drugs (medicines that can harm the liver) may add to the risk of liver damage. Immunosuppressants may have their effects reduced.
The one Minor interaction is with CYP1A2 substrates, drugs cleared by a liver enzyme that ashwagandha may speed up.
Altogether, these interactions span 1,374 individual medications. Use the search tool on this page to check your exact medications, and talk with your own doctor or pharmacist before combining this product with any prescription.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha Extract 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha Extract 600 mg interact with 1,373 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha Extract 600 mg interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract
Doxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Doxycyline interactionDronedaroneMultaq
How Dronedarone interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Dronedarone interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract + Drospirenone, Ethinyl Estradiol interactionDulaglutideTrulicity
How Dulaglutide interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root Extract + Dulaglutide interactionDuloxetineCymbalta, Drizalma Sprinkle, Irenka
How Duloxetine interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Duloxetine interactionDurvalumabImfinzi
How Durvalumab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Durvalumab interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Root Extract + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEculizumabSoliris
How Eculizumab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Eculizumab interactionEfalizumabRaptiva
How Efalizumab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Efalizumab interactionEfgartigimod Alfa-fcabVyvgart
How Efgartigimod Alfa-fcab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Efgartigimod Alfa-fcab interactionElotuzumabEmpliciti
How Elotuzumab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Elotuzumab interactionElranatamabElrexfio
How Elranatamab interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Elranatamab interactionEltrombopagAlvaiz, Promacta, Revolade
How Eltrombopag interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Eltrombopag interactionElvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil FumarateStribild
How Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate interactionEmapalumab-lzsgGamifant
How Emapalumab-lzsg interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root Extract + Emapalumab-lzsg interactionEmpagliflozinJardiance
How Empagliflozin interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root Extract + Empagliflozin, Metformin Hydrochloride interactionEmtricitabineEmtriva
How Emtricitabine interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Emtricitabine interactionEmtricitabine, Rilpivirine, TenofovirComplera
How Emtricitabine, Rilpivirine, Tenofovir interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Emtricitabine, Rilpivirine, Tenofovir interactionEmtricitabine, Rilpivirine, Tenofovir AlafenamideOdefsey
How Emtricitabine, Rilpivirine, Tenofovir Alafenamide interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract + Emtricitabine, Rilpivirine, Tenofovir Alafenamide interactionEmtricitabine, Tenofovir Alafenamide FumarateDescovy
How Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Emtricitabine, Tenofovir Alafenamide Fumarate interactionEnalapril MaleateEpaned, Vasotec
How Enalapril Maleate interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root Extract + Enalapril Maleate interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root Extract + Enalapril Maleate, Felodipine interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root Extract + Enalapril Maleate, Hydrochlorothiazide interactionEnsartinibEnsacove
How Ensartinib interacts with Ashwagandha Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root Extract + Ensartinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha Extract 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha Root Extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha Extract 600 mg, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Ashwagandha Extract 600 mg by BulkSupplements.com: Common Questions
Does Ashwagandha Extract 600 mg by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Ashwagandha Extract 600 mg safe to take during pregnancy?
Can I take it while breastfeeding?
Does ashwagandha work for anxiety?
What are the common side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha Extract 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha Extract 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha Extract 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
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