Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

B. Bifidum & B. Lactis Ingredients & Drug Interactions

by Custom Probiotics

B. Bifidum & B. Lactis label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B. Bifidum & B. Lactis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B. Bifidum & B. Lactis is a dietary supplement by Custom Probiotics with 2 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B. Bifidum & B. Lactis by Custom Probiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with B. Bifidum & B. Lactis by Custom Probiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B. Bifidum & B. Lactis by Custom Probiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This powder contains two active probiotic ingredients: Bifidobacterium bifidum and Bifidobacterium lactis. These are beneficial bacteria that live in your gut and are meant to support digestive and immune health.

The product contains no inactive fillers or other ingredients — just the two live cultures.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and gut balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Irritable bowel syndrome (IBS), Ulcerative colitis, Diarrhea — and 3 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Radiation-induced diarrhea, Ulcerative colitis, and more.

B. bifidum has some evidence behind it for irritable bowel syndrome (IBS) and respiratory tract infections — in both cases, the data suggests it's possibly effective. For hay fever (allergic rhinitis), generalized anxiety, and Alzheimer disease, we don't have enough reliable evidence yet to say whether it helps.

We couldn't check effectiveness data for B. lactis.

The evidence, ingredient by ingredient Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B. bifidum is generally well tolerated in healthy people. That said, if you have a weakened immune system, talk with your doctor first — the evidence is limited and these organisms haven't been studied extensively in that population.

Bloating and flatulence are reported with probiotic use in general, though they haven't been specifically tied to B. bifidum. One case of vomiting and fever was reported in a child taking B. bifidum with another probiotic, but it's unclear whether the probiotics caused it.

Very rare cases of Bifidobacterium sepsis have occurred in critically ill patients, though not from B. bifidum specifically.

Side effects, ingredient by ingredient Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, double-check before starting this product — they may reduce how well these probiotics work. Separate your doses by a few hours if your doctor approves.

We couldn't check B. lactis for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS or respiratory infections, and it's generally well tolerated in healthy people. If you have a weakened immune system or are on antibiotics, check with your pharmacist first.

Run your medications through the interaction checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B. Bifidum & B. Lactis, straight from the product label.

Brand Custom Probiotics
Net contents 0 Not Present
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 252139
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B. Bifidum & B. Lactis by Custom Probiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 Gram(s), 0.8 Gram(s)
Maximum serving Sizes:
0.1 Gram(s), 0.8 Gram(s)
IngredientAmount% DV
B. bifidum0 NP--
B. lactis0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions of use: Dissolve 1-2 scoops (enclosed) of the dairy-free probiotic powder in one glass of purified water and drink it. Do this first thing in the morning and/or at bedtime.

Storage

Bottles should be kept tightly closed and stored in the refrigerator to retain maximum potency.

General Statements

Please read enclosed dosage suggestion or visit www.customprobiotics.com

Formulation

Does not contain: Artificial colors, flavors, preservatives, sugar, gluten, soy, wheat or FOS.

Ultra potency

Dairy free probiotic powder

Formula

450 Billion CFU's per gram

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B. Bifidum & B. Lactis by Custom Probiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B. Bifidum & B. Lactis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B. Bifidum & B. Lactis by Custom Probiotics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.1 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

B. bifidum

Interacts with
182 drugs
0 NP per serving

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance....

B. bifidum monograph & interactions

B. lactis

0 NP per serving
Interaction report

B. Bifidum & B. Lactis by Custom Probiotics Drug Interactions

Want to check YOUR meds against B. Bifidum & B. Lactis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. bifidum 182

Individual Drug Interactions

The ingredients in B. Bifidum & B. Lactis interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in B. Bifidum & B. Lactis interact with drugs. Each result below shows which ingredient is responsible. B. bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in B. Bifidum & B. Lactis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B. Bifidum & B. Lactis, from the product label.

Custom Probiotics

See all Custom Probiotics products
Name
Custom Probiotics, Inc.
City
Glendale
State
California
ZipCode
91214
Phone Number
(800) 219-8405
Web Address
www.customprobiotics.com
Pharmacist Counseling Corner

B. Bifidum & B. Lactis by Custom Probiotics: Common Questions

Does B. Bifidum & B. Lactis by Custom Probiotics interact with any medications?
Yes. Based on its ingredients, B. Bifidum & B. Lactis has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B. Bifidum & B. Lactis contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
You can, but timing matters. Antibiotics can kill the live organisms in this probiotic, making it less effective. Talk with your pharmacist about spacing out your doses — usually a few hours apart works well.
Will this help my IBS?
B. bifidum is possibly effective for irritable bowel syndrome based on the evidence we have. Results vary from person to person, so give it time and see how you feel.
Is this safe if I have a weak immune system?
People with weakened immune systems should be cautious with live probiotics. Talk with your doctor before starting — they can advise you based on your specific situation.
Are there inactive ingredients or fillers in this?
No, this powder is just the two live probiotic organisms — no fillers or other inactive ingredients.
Can I take this while pregnant?
B. bifidum is rated possibly safe in pregnancy, but the evidence is limited. Talk with your doctor to make sure it's right for you. We don't have safety data on file for B. lactis during pregnancy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B. Bifidum & B. Lactis is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B. Bifidum & B. Lactis label
Go deeper

The Full Monographs Behind B. Bifidum & B. Lactis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

B. Bifidum & B. Lactis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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