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Dietary supplement

Children's Acidophilus Grape Flavor Ingredients & Drug Interactions

by CHK Nutrition

Children's Acidophilus Grape Flavor label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's Acidophilus Grape Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Children's Acidophilus Grape Flavor is a dietary supplement by CHK Nutrition with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Children's Acidophilus Grape Flavor by CHK Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's Acidophilus Grape Flavor by CHK Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Children's Acidophilus Grape Flavor by CHK Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 3 active probiotic ingredients: Lactobacillus acidophilus La-14, Bifidobacterium lactis BI-04, and Lactobacillus salivarius Ls-33. These are beneficial bacteria strains meant to support your child's digestive and gut health.

The remaining ingredients — sorbitol, xylitol, natural grape flavor, vegetable stearin, cellulose, citric acid, maltodextrin, silica, magnesium stearate, Luo Han Guo fruit extract, and carmine color — are inactive fillers, binders, and flavorings that make the tablet palatable for children.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and probiotic support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

The data we hold shows Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis in children and adults. For atopic disease (allergic conditions), it's rated possibly ineffective.

For acute respiratory distress syndrome, the evidence isn't established enough to rate it. We don't have effectiveness ratings on file for the other two probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy children and adults. Gastrointestinal side effects like stomach discomfort, belly pain, gas, bloating, diarrhea, or vomiting can occur when you take this probiotic along with other probiotics, but these are uncommon.

In rare cases, live bacteria preparations have been linked to serious infections (bacteremia, sepsis, or abscess) — but this almost always happens in patients whose immune systems are already compromised or whose gut barrier is damaged. A clinical trial of a multi-strain probiotic including one of the strains in this product reported two rashes and one case of itching, though it's unclear whether the probiotic itself caused them.

Talk with your child's doctor before starting this supplement.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If your child takes antibiotic drugs, let us know — we need to time the doses so the antibiotics don't kill off the beneficial bacteria in this supplement. We couldn't check two of the three active ingredients here for interactions, so running your child's exact medications through the checker on this page is important before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain digestive issues if your child has IBS, antibiotic-associated diarrhea, or related conditions — but the evidence is still developing. If your child is on antibiotics right now, space out the doses of this product and the antibiotic.

Check with your pediatrician or pharmacist before starting, especially if your child has a weakened immune system or any serious ongoing health condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's Acidophilus Grape Flavor, straight from the product label.

Brand CHK Nutrition
Barcode (UPC) 787500065721
Net contents 60 Chewable Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228646
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's Acidophilus Grape Flavor by CHK Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
787500065721
IngredientAmount% DV
Bifidobacterium lactis BI-040 NP--
Lactobacillus acidophilus La-140 NP--
Lactobacillus salivarius Ls-330 NP--
Proprietary Probiotic Blend0 NP--

Other ingredients: Sorbitol, Xylitol, natural Grape flavor, Vegetable Stearin, Cellulose, Citric Acid, Maltodextrin, Silica, Magnesium Stearate, Luo Han Guo fruit extract, Carmine color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no salt, dairy, wheat, soy, gluten, preservatives, artificial colors or flavors.

All natural source Survives stomach acid Shelf stable

Our probiotic strains are stabilized using a patented pol matrix system (patent # 6,653,062) that provides shelf stability at normal room temperature.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, children five (5) years and older chew one (1) tablet daily during a meal, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

No refrigeration required.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

General Statements

New day. Fresh start. Better health.

Formula

1 billion viable cells per tablet

Each bio-enhanced acid resistant strain (BEARS) has been specifically designed to survive stomach acid secretions during digestion. BEARS eliminates the need for enteric coating by preventing the destruction of viable cells that occurs when weaker strains are exposed to an acid environment. Children's Acidophilus is a high-potency, multiple species probiotic supplement. It provides three of the best probiotic strains for children in amounts that will support and nurture a healthy digestive system.

It provides three of the best probiotic strains for children in amounts that will support and nurture a healthy digestive system.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's Acidophilus Grape Flavor by CHK Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's Acidophilus Grape Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's Acidophilus Grape Flavor by CHK Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Sorbitol, Xylitol, Natural Grape flavor, Vegetable Stearin, Cellulose, Citric Acid, Maltodextrin, Silica, Magnesium Stearate, Luo Han Guo fruit extract, Carmine color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's Acidophilus Grape Flavor by CHK Nutrition Drug Interactions

Want to check YOUR meds against Children's Acidophilus Grape Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in Children's Acidophilus Grape Flavor interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Children's Acidophilus Grape Flavor interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's Acidophilus Grape Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's Acidophilus Grape Flavor, from the product label.

CHK Nutrition

See all CHK Nutrition products
Name
CHK Nutrition
Street Address
3930 E Calvary Rd
City
Duluth
State
MN
ZipCode
55803
Phone Number
877-538-8388
Pharmacist Counseling Corner

Children's Acidophilus Grape Flavor by CHK Nutrition: Common Questions

Does Children's Acidophilus Grape Flavor by CHK Nutrition interact with any medications?
Yes. Based on its ingredients, Children's Acidophilus Grape Flavor has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's Acidophilus Grape Flavor contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child while they're on antibiotics?
You can, but timing matters. Antibiotics can kill the live bacteria in this probiotic, so separate the doses as much as possible — ask your pharmacist or doctor for the best schedule for your child's specific antibiotic.
What are probiotics supposed to do?
Probiotics are beneficial bacteria that help support digestive and gut health. This product contains three strains that have been studied for conditions like irritable bowel syndrome and diarrhea from antibiotics.
Can this cause side effects in kids?
It's generally well tolerated, but some children may have mild belly discomfort, gas, or bloating when first starting it. Rashes have been reported rarely in trials. If your child has any reaction, stop and call your doctor.
Is it safe during pregnancy or breastfeeding?
The data on Lactobacillus acidophilus rates it as possibly safe in pregnancy. We don't have safety information on file for the other two strains or for breastfeeding — talk to your OB or pediatrician for personalized advice.
Why does this taste like grape if it has bacteria in it?
The grape flavor is a natural flavoring added to the tablet to make it easier for children to take. The live bacteria are the active ingredient, and the rest is filler and flavoring to make it palatable.
Do I need to refrigerate it?
That information isn't in the product facts we have on file — check the label or call the manufacturer for storage instructions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Children's Acidophilus Grape Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's Acidophilus Grape Flavor label
Go deeper

The Full Monographs Behind Children's Acidophilus Grape Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Children's Acidophilus Grape Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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