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Dietary supplement

B. Breve Ingredients & Drug Interactions

by Custom Probiotics

B. Breve label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B. Breve against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B. Breve is a dietary supplement by Custom Probiotics with 1 active ingredient. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. Breve. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B. Breve by Custom Probiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with B. Breve by Custom Probiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B. Breve by Custom Probiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

B. Breve by Custom Probiotics is a single-strain probiotic powder containing one active ingredient: Bifidobacterium breve, a live bacterium that naturally occurs in the human gut.

It comes with no inactive ingredients listed. B.

Breve is meant to support digestive and immune health by populating your gut with beneficial bacteria. The product contains living organisms, so storage and timing matter — especially when you're taking antibiotics, which can kill the bacteria before they establish themselves.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Breve's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Digestive health and gut microbiome support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Clostridioides difficile infection, Irritable bowel syndrome (IBS), Ulcerative colitis — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Constipation, Rotaviral diarrhea, Helicobacter pylori, Ulcerative colitis, and more.

The evidence for B. Breve is limited and mixed.

For age-related cognitive decline and sepsis (a serious bloodstream infection), the data suggests it's possibly ineffective. For antibiotic-associated diarrhea, hay fever, and atopic disease (a group of allergic conditions), there isn't enough reliable evidence to rate whether it works or not.

In short, we don't have solid proof that B. Breve delivers the benefits many people hope for, so talk with your doctor about what realistic expectations are for your specific situation.

The evidence, ingredient by ingredient Bifidobacterium Breve

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B. Breve is generally well tolerated in healthy people.

However, caution is needed if you're very ill or have a weakened immune system — the safety data are limited in those groups, and there have been rare cases of the bacteria itself entering the bloodstream (bacteremia) in critically ill patients and preterm infants. Some people report bloating and flatulence with probiotics in general, though this hasn't been specifically reported with B.

Breve. Because the safety evidence is limited overall, check with your healthcare provider before you start, especially if you're hospitalized, immunocompromised, or have serious underlying illness.

Side effects, ingredient by ingredient Bifidobacterium Breve

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start B. Breve, check with your doctor or pharmacist if you take antibiotics.

Because B. Breve contains live organisms, antibiotics taken at the same time can reduce its effectiveness — your healthcare provider can help you time them properly.

No other medication interactions are documented in our data for the ingredients we could check, but that doesn't guarantee none exist, so review your full medication list with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

B. Breve is a single-strain probiotic that's generally well tolerated in healthy people, but the evidence it actually works for common digestive or immune issues is weak or missing.

The main medication concern is antibiotics — they can kill the live bacteria in the product, so you'll need to space them apart. If you're very ill, immunocompromised, or hospitalized, talk with your doctor or pharmacist before taking it, and definitely check your other medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B. Breve, straight from the product label.

Brand Custom Probiotics
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 252134
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B. Breve by Custom Probiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 Gram(s), 0.8 Gram(s)
Maximum serving Sizes:
0.1 Gram(s), 0.8 Gram(s)
IngredientAmount% DV
B. Breve0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions of use: Dissolve 1-2 scoops (enclosed) of the dairy-free probiotic powder in one glass of purified water and drink it. Do this first thing in the morning and/or at bedtime.

Storage

Bottles should be kept tightly closed and stored in the refrigerator to retain maximum potency.

General Statements

Please read enclosed dosage suggestion or visit www.customprobiotics.com

Formulation

Does not contain: Artificial colors, flavors, preservatives, sugar, gluten, soy, wheat or FOS.

Ultra potency

Dairy free probiotic powder

Formula

300 Billion cfu's per gram

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B. Breve by Custom Probiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B. Breve label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B. Breve by Custom Probiotics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.1 Gram(s) Dosage formPowder Amounts shown are per serving.

B. Breve

Interacts with
182 drugs
0 NP per serving

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies...

B. Breve monograph & interactions
Interaction report

B. Breve by Custom Probiotics Drug Interactions

Want to check YOUR meds against B. Breve?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. Breve 182

Individual Drug Interactions

The ingredients in B. Breve interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in B. Breve interact with drugs. Each result below shows which ingredient is responsible. B. Breve

Each ingredient & the kinds of drugs it affects

For each ingredient in B. Breve with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

B. Breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
B. Breve full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B. Breve, from the product label.

Custom Probiotics

See all Custom Probiotics products
Name
Custom Probiotics
City
Glendale
State
California
ZipCode
91214
Phone Number
(800) 219-8405
Web Address
www.customprobiotics.com
Pharmacist Counseling Corner

B. Breve by Custom Probiotics: Common Questions

Does B. Breve by Custom Probiotics interact with any medications?
Yes. Based on its ingredients, B. Breve has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B. Breve contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take B. Breve while I'm on an antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in B. Breve and make it less effective. Ask your doctor or pharmacist how far apart to space them — usually a few hours is recommended — and they can tell you the best timing for your specific antibiotic.
Does B. Breve actually work for digestive health?
The evidence is weak. For antibiotic-associated diarrhea, hay fever, and other common issues, we don't have enough reliable research to say whether it works. For age-related cognitive decline and sepsis, the data suggest it's likely ineffective. Talk with your doctor about realistic expectations for your situation.
Is B. Breve safe if I'm in the hospital or have a weakened immune system?
Caution is needed. There have been rare cases of the bacteria itself entering the bloodstream in very ill patients and preterm infants. If you're hospitalized, immunocompromised, or seriously ill, check with your healthcare provider before taking it — the safety data in these groups are limited.
What's in this product besides the bacteria?
Just the active ingredient: Bifidobacterium breve. There are no inactive ingredients listed, so you're getting the probiotic without fillers or binders.
Can I take B. Breve while pregnant or breastfeeding?
We don't have specific safety data on file for B. Breve in pregnancy or lactation. Talk with your doctor or pharmacist about whether it's right for you in either situation — they can weigh the benefits and risks for your personal health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B. Breve is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B. Breve label
Go deeper

The Full Monographs Behind B. Breve’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph →
Sources

Sources & How We Checked

B. Breve's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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