Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Acidophilus and Bifidus 60 Billion CFUs Ingredients & Drug Interactions

by Custom Probiotics

Acidophilus and Bifidus 60 Billion CFUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acidophilus and Bifidus 60 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acidophilus and Bifidus 60 Billion CFUs is a dietary supplement by Custom Probiotics with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus, B. bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Total Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains five active probiotic ingredients: L. acidophilus, B. bifidum, L. plantarum, B. animalis lactis, and L. rhamnosus — all live microorganisms meant to support your gut. The blend is rounded out with inactive ingredients like microcrystalline cellulose, gelatin, magnesium stearate, and silica, which help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gut balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

L. acidophilus and B. bifidum are both rated possibly effective for irritable bowel syndrome (IBS) and possibly effective for antibiotic-associated diarrhea. L. acidophilus is also possibly effective for Helicobacter pylori infection and bacterial vaginosis, while B. bifidum is possibly effective for respiratory tract infections.

For other conditions like allergic rhinitis, Alzheimer disease, and generalized anxiety disorder, the evidence isn't established enough for us to rate it. We hold no effectiveness data for the other three ingredients in the blend.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both L. acidophilus and B. bifidum are generally well tolerated in healthy adults and children. That said, because they're live microorganisms, there's a small theoretical risk they could cause infection in certain patients — particularly those with very weakened immune systems — so check with your doctor before starting.

Gastrointestinal side effects like bloating, flatulence, and mild abdominal discomfort can occur with probiotic use, though they're uncommon. In a clinical trial, a probiotic blend containing L. acidophilus and B. bifidum was linked to a few cases of rash and itching, but it's unclear whether the probiotics themselves were responsible.

For pregnancy, the available data suggest L. acidophilus and B. bifidum are possibly safe, but lactation data aren't on file — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Separate your antibiotic doses from this probiotic by several hours — antibiotics can kill the live organisms in the product and reduce its effectiveness. Check your exact antibiotic prescription with your pharmacist or doctor before starting this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, and a few other conditions, though the evidence is still developing. The main thing to watch is taking it separately from antibiotics, since they can kill the live organisms.

If you have a weakened immune system or are pregnant or breastfeeding, discuss this product with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acidophilus and Bifidus 60 Billion CFUs, straight from the product label.

Brand Custom Probiotics
Barcode (UPC) 674627398408
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 309966
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
674627398408
IngredientAmount% DV
L. acidophilus0 NP--
B. bifidum0 NP--
L. plantarum0 NP--
B. animalis lactis0 NP--
L. rhamnosus0 NP--
Total Probiotic Blend0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule, one to three times daily, on an empty stomach or at bed time with water, or as a prescribed by your health care professional.

Formula

Adult formula CP-1: is a proprietary blend of five highly viable strains of live microorganisms, with a total count of 60 billion cfu's Lactobacilli and Bifidobacteria per capsule guaranteed at the time of expiration. Most specific for small and large intestines.

Formulation

Probiotics: Lactobacilli and Bifidobacteria are food or dietary supplements generally termed as probiotics. The word probiotic is derived from the Greek meaning "for life".

High count, multi-strain 60 billion CFU's/ Capsule Adult formula CP-1

Dairy free Does not contain: artificial colors, flavors, sugar, soy, preservatives, wheat, dairy, gluten, corn, FOS or yeast.

Made in the USA

Storage

Storage: Keep refrigerated to retain maximum potency

Precautions

Do not use if seal is broken.

General Statements

New!

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acidophilus and Bifidus 60 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics Drug Interactions

Want to check YOUR meds against Acidophilus and Bifidus 60 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. acidophilus 182
B. bifidum 182

Individual Drug Interactions

The ingredients in Acidophilus and Bifidus 60 Billion CFUs interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Acidophilus and Bifidus 60 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus B. bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Acidophilus and Bifidus 60 Billion CFUs with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acidophilus and Bifidus 60 Billion CFUs, from the product label.

Custom Probiotics

See all Custom Probiotics products
Name
Custom Probiotics Inc.
City
Glendate
State
California
ZipCode
91214
Phone Number
(800) 219-8405
Web Address
www.customprobiotics.com
Pharmacist Counseling Corner

Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics: Common Questions

Does Acidophilus and Bifidus 60 Billion CFUs by Custom Probiotics interact with any medications?
Yes. Based on its ingredients, Acidophilus and Bifidus 60 Billion CFUs has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acidophilus and Bifidus 60 Billion CFUs contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
Not at the same time. Since this product contains live probiotic bacteria, antibiotics will kill them and make the probiotics less effective. Your doctor or pharmacist can tell you how to space them apart — usually a few hours is enough.
Is this safe if I'm pregnant?
L. acidophilus and B. bifidum are both rated possibly safe in pregnancy, but lactation data aren't on file for either. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while breastfeeding.
What does this probiotic actually do?
The L. acidophilus and B. bifidum in this blend are possibly effective for IBS, antibiotic-associated diarrhea, respiratory infections, and a couple of other conditions. Evidence is still developing for several of these uses, so results vary by person.
Will this cause bloating or gas?
Gastrointestinal side effects like bloating and flatulence can happen with probiotics, but they're uncommon. A few people in trials also reported mild abdominal discomfort or nausea, though these aren't frequent.
Is it safe if I have a weak immune system?
Probiotics are generally well tolerated, but if your immune system is significantly weakened, there's a small theoretical risk of infection. Check with your doctor before starting this product.
What's in the capsule besides the probiotics?
The capsule is made with microcrystalline cellulose, gelatin, magnesium stearate, and silica — these are inactive ingredients that help hold the formula together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Acidophilus and Bifidus 60 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acidophilus and Bifidus 60 Billion CFUs label
Go deeper

The Full Monographs Behind Acidophilus and Bifidus 60 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Acidophilus and Bifidus 60 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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