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Dietary supplement

B12 Methylcobalamin 3000 mcg with Folic Acid Ingredients & Drug Interactions

by Allergy Research Group

B12 Methylcobalamin 3000 mcg with Folic Acid label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B12 Methylcobalamin 3000 mcg with Folic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B12 Methylcobalamin 3000 mcg with Folic Acid is a dietary supplement by Allergy Research Group with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase NSK-SD. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product's single active ingredient is nattokinase NSK-SD, an enzyme derived from natto (fermented soybeans). The inactive ingredients are soybean oil, gelatin, glycerin, glycerin fatty acid ester, soybean lecithin, and beeswax.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Nattokinase product and its label doesn't state a use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for nattokinase in the conditions listed—angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome—is insufficient to rate. In other words, we don't have reliable data yet showing whether it works for these purposes.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in short-term use, but because of its blood-thinning effects, it's not appropriate for people at risk of bleeding. The safety data advises against use during pregnancy and breastfeeding.

Rare reports of bleeding, including a case of brain hemorrhage, have been documented. Additionally, some people may have hypersensitivity reactions to nattokinase or related proteins in natto, including anaphylaxis, with symptoms appearing within 2 hours of taking it—mainly affecting the throat and larynx.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on any blood thinners or antiplatelet drugs (such as warfarin, apixaban, or aspirin)—there's a Moderate risk of increased bleeding, including rare serious bleeding. Also confirm if you're on blood pressure medications, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people interested in nattokinase's potential cardiovascular effects who don't take blood thinners or blood pressure medications. If you're on either of those drug types, or if you have a bleeding disorder, pregnancy, or breastfeeding, talk with your doctor or pharmacist before starting it.

Bring a list of your medications to your pharmacist and check them against the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B12 Methylcobalamin 3000 mcg with Folic Acid, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947765603
Net contents 50 Vegetarian Lozenge(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304227
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
60
UPC/BARCODE
713947765603
IngredientAmount% DV
Nattokinase NSK-SD100 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Glycerin Fatty Acid Ester, Soybean Lecithin, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

B12 methylcobalamin Coenzyme Vitamin B12 in the form of methylcobalamin, with folic acid.

Suggested/Recommended/Usage/Directions

Suggested use As a dietary supplement, adults place 1 lozenge daily under tongue 30 seconds before swallowing, or as directed by a healthcare professional.

Precautions

Do not exceed recommended dose.

Contains: Soy.

Storage

Keep in a cool, dry place, tightly capped.

Store in a cool, dry place, tightly capped.

FDA Statement of Identity

Dietary Supplement

Formulation

Product of Japan

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B12 Methylcobalamin 3000 mcg with Folic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container60 Amounts shown are per serving.

Nattokinase NSK-SD

Interacts with
289 drugs
100 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase NSK-SD monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Glycerin Fatty Acid Ester, Soybean Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group Drug Interactions

Want to check YOUR meds against B12 Methylcobalamin 3000 mcg with Folic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase NSK-SD 289

Individual Drug Interactions

The ingredients in B12 Methylcobalamin 3000 mcg with Folic Acid interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in B12 Methylcobalamin 3000 mcg with Folic Acid interact with drugs. Each result below shows which ingredient is responsible. Nattokinase NSK-SD

Each ingredient & the kinds of drugs it affects

For each ingredient in B12 Methylcobalamin 3000 mcg with Folic Acid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase NSK-SD2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase NSK-SD full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B12 Methylcobalamin 3000 mcg with Folic Acid, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group: Common Questions

Does B12 Methylcobalamin 3000 mcg with Folic Acid by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, B12 Methylcobalamin 3000 mcg with Folic Acid has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B12 Methylcobalamin 3000 mcg with Folic Acid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
You should not take this product with aspirin without clearing it first with your doctor or pharmacist. There's a documented case of brain bleeding in someone who combined nattokinase with aspirin. This is a Moderate-severity interaction.
Is nattokinase safe during pregnancy?
No, the safety data advises against it during pregnancy. There isn't enough information to know whether it's safe, so it's best avoided.
Is nattokinase safe while breastfeeding?
Safety while breastfeeding is unknown, so it's best avoided during that time. Talk with your doctor or pharmacist about whether it's right for you.
Can nattokinase cause an allergic reaction?
Yes. Some people can have hypersensitivity reactions to nattokinase or related proteins in natto, ranging from throat and larynx symptoms to anaphylaxis. Symptoms typically appear within 2 hours of taking it. If you're sensitive to natto or have a soy allergy, discuss this with your pharmacist first.
Does this product actually work for heart disease or fatigue?
The evidence we hold doesn't establish that nattokinase works reliably for angina, atherosclerosis, cardiovascular disease, or chronic fatigue. The research available so far is insufficient to rate its effectiveness for these purposes.
What is nattokinase?
Nattokinase is an enzyme from natto, a fermented soybean food. It has blood-thinning and blood-vessel-clearing properties, which is why it may lower blood pressure and why it interacts with blood thinners.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B12 Methylcobalamin 3000 mcg with Folic Acid label
Go deeper

The Full Monographs Behind B12 Methylcobalamin 3000 mcg with Folic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

B12 Methylcobalamin 3000 mcg with Folic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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