Bacopa Monnieri Extract Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Bacopa Monnieri Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bacopa Monnieri Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 930 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacopa monnieri extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bacopa Monnieri Extract by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Bacopa Monnieri Extract by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bacopa Monnieri Extract by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Bacopa monnieri extract powder. Bacopa is a traditional herb used in Ayurvedic medicine, and extracts of it are being studied for effects on memory and brain function.
There are no inactive ingredients listed for this powder formulation.
Does it work?
Not established
The evidence for bacopa's effectiveness isn't established in the data we hold. The product is marketed for uses including Alzheimer disease, cognitive function, ADHD, sexual dysfunction, back pain, and cognitive impairment — but all of these carry a rating of insufficient reliable evidence to rate.
That means studies to date haven't built a solid case for any of these claims. If you're considering bacopa for a specific purpose, it's worth discussing with your doctor or pharmacist what the current research actually shows.
How safe is it?
Well-documented data
Bacopa is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are gastrointestinal — abdominal cramps, diarrhea, nausea, and dry mouth.
Some people also report headache, drowsiness, insomnia, vivid dreams, bloating, and decreased appetite. Rates of GI upset range from 12% to 30% in trials.
Because there isn't enough safety information, the data advises against using bacopa during pregnancy or while breastfeeding — talk with your doctor or pharmacist if you're in either situation and thinking about this supplement.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take any medications metabolized by your liver's P450 enzymes — including many heart drugs, blood thinners, statins, antidepressants, and diabetes medications (all Moderate severity). Also double-check if you use anticholinergic drugs, cholinergic drugs, cevimeline (Evoxac), or thyroid hormone.
Bacopa may change how these work or increase side effects.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Bacopa monnieri extract is one to run through a medication checker before you start, given its potential to interact with a very large number of drugs through liver enzyme effects and its interference with certain medication classes. It's generally well tolerated for GI side effects in the short term, but long-term safety data are sparse.
If you take any prescription or over-the-counter medications — especially those for heart, mood, blood sugar, or seizures — confirm with your own doctor or pharmacist that bacopa won't interfere before adding it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bacopa Monnieri Extract, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Net contents | 0 Not Present |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 244304 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bacopa Monnieri Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bacopa monnieri extract powder | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Support brain & memory functions
Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast
V vegan
Ethically sourced Scientifically tested Premium grade ingredients
Formula
Standardized extract powder derived from Bacopa monnieri leaves
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take up to 1000 mg daily, or as directed by physician.
Precautions
Keep out of reach of children.
Pregnant or lactating women should consult your physician before use.
Storage
Store in a dry, cool & dark.
FDA Disclaimer Statement
Warning: This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Batch No. ARK-P05
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bacopa Monnieri Extract by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bacopa Monnieri Extract by Herbadiet
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Amounts shown are per serving.
Bacopa monnieri extract powder
Interacts with930 drugs
Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...
Bacopa monnieri extract powder monograph & interactionsBacopa Monnieri Extract by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Bacopa Monnieri Extract by Herbadiet interacts with a substantial number of medications, primarily through effects on liver enzymes that metabolize many common drugs.
The most serious concern is with drugs processed by your liver's cytochrome P450 system — bacopa may slow how your body clears these medications, raising their levels and side effects. This affects four major enzyme groups (CYP1A2, CYP2C9, CYP2C19, and CYP3A4 substrates), all rated Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
Additionally, bacopa may interfere with anticholinergic drugs (used for conditions like overactive bladder and certain types of poisoning) by reducing their effectiveness, and it may amplify the effects of cholinergic drugs (which increase acetylcholine activity). There's also a reported case of someone taking cevimeline (Evoxac, used for dry mouth in Sjögren syndrome) who experienced sweating, nausea, and a rapid heartbeat after adding bacopa — a Moderate-severity interaction.
Finally, bacopa may have additive effects with thyroid hormone, though this is rated Minor.
Altogether, these interactions span 931 individual medications. Because the enzyme effects are based on lab evidence and clinical significance remains unclear, the actual risk for any one drug is uncertain — but the sheer number affected means it's essential you check your exact medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bacopa Monnieri Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bacopa Monnieri Extract interact with 930 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bacopa Monnieri Extract interact with drugs. Each result below shows which ingredient is responsible. Bacopa monnieri extract powder
Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Omeprazole interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa Monnieri Extract Powder + Aspirin, Pentazocine interactionAtazanavirReyataz
How Atazanavir interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Monnieri Extract Powder + Atorvastatin Calcium interactionAtovaquone, ProguanilMalarone
How Atovaquone, Proguanil interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
Read the full Bacopa Monnieri Extract Powder + Atovaquone, Proguanil interactionAtropineSal-Tropine
How Atropine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine interactionAtropine Methyl Nitrate, Digestive EnzymesFestalan
How Atropine Methyl Nitrate, Digestive Enzymes interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine Methyl Nitrate, Digestive Enzymes interactionAtropine SulfateAtropine Sulfate, Isopto Atropine
How Atropine Sulfate interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine Sulfate interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl SalicylateUrinary Antiseptic 2, Urised
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, DifenoxinMotofen
How Atropine, Difenoxin interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Difenoxin interactionAtropine, DiphenoxylateLofene, Lomotil
How Atropine, Diphenoxylate interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Diphenoxylate interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, ScopolamineColytrol
How Atropine, Hyoscyamine, Scopolamine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Hyoscyamine, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Bacopa Monnieri Extract — through 1 ingredient. Tap an ingredient for the detail:
Bacopa Monnieri Extract PowderAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Monnieri Extract Powder + Atropine, Morphine Sulfate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bacopa Monnieri Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bacopa monnieri extract powder
Anticholinergic Drugs
Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.
Cevimeline (Evoxac)
Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.
Cholinergic Drugs
Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Thyroid Hormone
Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.
Brand information
Manufacturer and brand details for Bacopa Monnieri Extract, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- Street Address
- 11, Sector - 14
- City
- Rohtak
- State
- Haryana
- ZipCode
- 124001
- Web Address
- www.herbadiet.in
Bacopa Monnieri Extract by Herbadiet: Common Questions
Does Bacopa Monnieri Extract by Herbadiet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is bacopa monnieri, and what's it supposed to do?
Can I take this while I'm pregnant or breastfeeding?
What side effects should I watch for?
Does bacopa interact with a lot of medications?
How long have people been using this safely?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bacopa Monnieri Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bacopa Monnieri Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bacopa Monnieri Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bacopa 12 references
- Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
- Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
- Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
- Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
- Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
- Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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