Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Bee Propolis Trio Ingredients & Drug Interactions

by NaturaNectar

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bee Propolis Trio is a dietary supplement by NaturaNectar with 2 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Brazilian Bee Propolis Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bee Propolis Trio by NaturaNectar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bee Propolis Trio contains 2 active ingredients: Brazilian Bee Propolis Blend and Propolis Water Extract. Both are forms of propolis, a resinous mixture that honeybees collect from plants and use to build and seal their hives.

The product also includes inactive ingredients — cellulose, magnesium stearate, and silicon dioxide — which are standard capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: respiratory, immune, liver and prostate health.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Common cold, Chronic obstructive pulmonary disease (COPD), Nonalcoholic fatty liver disease (NAFLD), Gingivitis, Periodontitis — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Chronic obstructive pulmonary disease (COPD), Nonalcoholic fatty liver disease (NAFLD), Common cold, Gingivitis, and more.

The propolis in this product is possibly effective for oral mucositis (mouth inflammation or sores) and herpes labialis (cold sores). It's also possibly effective for diabetes.

The evidence for dengue fever is insufficient to rate. These ratings apply to both the Brazilian Bee Propolis Blend and the Propolis Water Extract, since they're the same ingredient in different forms.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated in the short term. The most common side effect when taken by mouth is headache — around 7% of people taking 250 mg twice daily for 4 months reported mild headache in one trial.

Allergic reactions are possible, especially if you're sensitive to bee products; severe allergic reactions are rare but can happen. If you're allergic to bees or bee products, you're at higher risk.

There isn't enough safety data to know whether propolis is safe in pregnancy, so it's best avoided during pregnancy. It's rated possibly safe while breastfeeding, but again, data is limited.

If you're pregnant or breastfeeding, talk with your pharmacist or doctor about whether this is right for you.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bee Propolis Trio, double-check if you're on blood thinners or antiplatelet drugs — propolis may increase bleeding risk. Also check if you take warfarin (Coumadin) or any drug metabolized by CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2E1 enzymes; propolis might theoretically raise your levels of these medications.

Use the medication checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bee Propolis Trio may help with cold sores, mouth sores, or blood sugar — but it's a big player with medications. If you take any prescriptions, especially blood thinners, warfarin, or drugs your liver metabolizes, check your medications on this page first.

It's generally well tolerated, but watch for headache and any signs of allergic reaction, especially if you're sensitive to bee products.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bee Propolis Trio, straight from the product label.

Brand NaturaNectar
Barcode (UPC) 837654326558
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 27, 2014
DSLD ID 38508
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bee Propolis Trio by NaturaNectar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
837654326558
IngredientAmount% DV
Brazilian Bee Propolis Blend100 mg--
Propolis Water Extract3 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

MY WELLNESS ZONE(TM)

BRAZILIAN PROPOLIS BLEND 85% BROWN 10% GREEN 5% RED

G EXTRACTION

General Statements

THIS PRODUCT SUPPORTS THE HEALTH OF: - Respiratory - Immune - Hepatic System* - Liver - Mucous - Prostate - Membrane Cells*

Protect & Activate Wellness, Naturally

Promotes a healthy inflammation response*

All NaturaL

Brand IP Statement(s)

(C)2013 NaturaNectar LLC

FLAV(TM)-M15 and PWE(TM)-MD are obtained by NaturaNectar’s exclusive Green Extraction(TM) for purity, standardization and potency

Formula

A natural source of active compound CAPE

Formulation

Gluten Free

NaturaNectar Bee Propolis Trio does not contain alcohol, sugar, starch, wheat, gluten, yeast, milk (lactose), egg, shellfish, artificial preservatives, flavors, dyes or colors.

FDA Statement of Identity

Daily Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one capsule by mouth one or two times daily to support overall health.*

May be taken in conjunction with our other unique life solutions daily or as recommended to help protect and activate your wellness, naturally.*

Precautions

Caution: As with any nutritional supplement, it is advised to consult your physician before taking, especially if pre-existing conditions are present.

Do not take if pregnant or breastfeeding.

Use with caution if allergic to bee products.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

*THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

See for yourself

Bee Propolis Trio by NaturaNectar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bee Propolis Trio by NaturaNectar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Brazilian Bee Propolis Blend

Interacts with
921 drugs
100 mg per serving Form: Chrysin, Flavonoids, Galangin, Pinocembrin, Tecto-Chrysin

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Brazilian Bee Propolis Blend monograph & interactions

Propolis Water Extract

Interacts with
921 drugs
3 mg per serving Form: Caffeic Acid, CAPE, Cinnamic Acid, Ferulic Acid

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Propolis Water Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bee Propolis Trio by NaturaNectar Drug Interactions

Want to check YOUR meds against Bee Propolis Trio?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Bee Propolis Trio with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Brazilian Bee Propolis Blend8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Bee Propolis Trio, from the product label.

NaturaNectar

See all NaturaNectar products
Name
NaturaNectar LLC
Street Address
1560 Sawgrass Corporate Pkwy, 4th Floor
City
Sunrise
State
FL
ZipCode
33323
Phone Number
800.609.7794
Web Address
naturanectar.com
Pharmacist Counseling Corner

Bee Propolis Trio by NaturaNectar: Common Questions

Does Bee Propolis Trio by NaturaNectar interact with any medications?
Yes. Based on its ingredients, Bee Propolis Trio has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bee Propolis Trio contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm allergic to bees?
No — you should avoid it. Propolis is a bee product, and people allergic to bees or bee products are more likely to have allergic reactions to it. Severe allergic reactions are rare but possible.
What's the difference between the two propolis ingredients in this product?
Both are propolis — one is a Brazilian Bee Propolis Blend and the other is a Propolis Water Extract. They're the same ingredient in different forms, so they have the same interactions and effects.
Is propolis safe during pregnancy?
There isn't enough reliable safety information, so it's best avoided during pregnancy. Talk with your pharmacist or doctor for personalized advice.
Will this cause headaches?
Headache is the most common side effect. In one trial, about 7% of people taking 250 mg twice daily for 4 months reported mild headache. Most people don't experience it.
Does this product actually work for cold sores?
Propolis is rated possibly effective for cold sores (herpes labialis), which means there's evidence it may help — but the evidence isn't definitive.
Is propolis safe while breastfeeding?
It's rated possibly safe, but there isn't much data. Talk with your pharmacist or doctor about whether this is the right choice for you while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bee Propolis Trio is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bee Propolis Trio label
Go deeper

The Full Monographs Behind Bee Propolis Trio’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Bee Propolis Trio's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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