Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Beets Cardio Gummies Ingredients & Drug Interactions

by Goli Nutrition

Beets Cardio Gummies label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beets Cardio Gummies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Beets Cardio Gummies is a dietary supplement by Goli Nutrition with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 913 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet Root Extract, Powder, Sodium, Coenzyme Q-10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Beets Cardio Gummies by Goli Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Beets Cardio Gummies by Goli Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Beets Cardio Gummies by Goli Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Beets Cardio Gummies contain four active ingredients. Sodium contributes electrolyte balance but is present in amounts you should consider against your overall dietary intake.

Vitamin B12 supports red blood cell formation and nerve function. Coenzyme Q10 (CoQ10) is an antioxidant your body makes naturally and uses for cellular energy.

Beet root extract, powder provides naturally occurring nitrates and betalains, plant compounds linked to blood vessel health. The product also contains inactive ingredients—tapioca syrup, cane sugar, water, natural flavors, pectin, malic acid, sodium citrate, citric acid, and sunflower lecithin—which give the gummies their texture and taste.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support cardiovascular health and heart energy.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Congestive heart failure, Congestive heart failure (CHF), Angina, Atherosclerosis — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF) (Natural Medicines).
  • Also on file: Beet is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Dyslipidemia, Hypertension, Hypertriglyceridemia, and more.

The evidence for these gummies' cardiovascular benefits is mixed. Beet root extract is possibly effective for athletic performance and exercise-related muscle soreness, though the data on blood pressure specifically is conflicting—some studies show modest benefit, others show none.

Vitamin B12 is effective for treating B12 deficiency itself, but there's no evidence it improves heart health in people with normal B12 levels. CoQ10 is possibly effective for congestive heart failure and migraine, but insufficient evidence exists for its use in general cardiovascular wellness.

The product positions itself as cardio support, but the evidence for a heart-health benefit in people without specific deficiencies or conditions is not established in our data.

The evidence, ingredient by ingredient Sodium Vitamin B12 Coenzyme Q10 Beet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated in normal dietary amounts, but too much—especially from supplements—can raise blood pressure, strain your heart, and stress your kidneys. The safety caution here is that these gummies add sodium to your diet; if you're watching sodium intake or have high blood pressure, heart disease, or kidney disease, you need to account for this.

Vitamin B12 is very safe; excess is excreted in urine, and it's needed in pregnancy and breastfeeding. CoQ10 is generally well tolerated, with only rare reports of gastrointestinal upset, headache, dizziness, or skin itching.

Beet as a food is safe for most people, though concentrated supplements lack robust safety data; some people report red or black stools, which is harmless. Very large amounts of beet theoretically carry a small risk of low calcium or kidney stress.

Side effects, ingredient by ingredient Sodium Vitamin B12 Coenzyme Q10 Beet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Beet, Vitamin B12, Coenzyme Q10, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 914 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Beets Cardio Gummies, check with your pharmacist if you take blood pressure medications (sodium and CoQ10 may affect them), warfarin or other blood thinners (CoQ10 may reduce effectiveness), metformin (B12 may interact), lithium (sodium alters its levels), corticosteroids (sodium may raise blood sodium), cancer chemotherapy drugs like cyclophosphamide (CoQ10 may reduce effectiveness), or any medication your liver breaks down heavily (beet extract may affect levels). No interactions are documented for the ingredients we could not fully check, but absence of data is not proof of safety.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in beet-based cardiovascular support and have no drug interactions with the list above, these gummies are generally tolerable. However, if you take blood pressure medication, warfarin, metformin, lithium, corticosteroids, chemotherapy, or any drug your liver processes heavily, check your medications first—the interactions here are real.

Talk to your pharmacist or doctor before starting, especially if you're watching sodium, pregnant, or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beets Cardio Gummies, straight from the product label.

Brand Goli Nutrition
Barcode (UPC) 055840404006
Net contents 60 Gummy(ies)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337950
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beets Cardio Gummies by Goli Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummie(s)
Maximum serving Sizes:
2 Gummie(s)
Servings per container
30
UPC/BARCODE
055840404006
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Sodium10 mg1%
Vitamin B1212 mcg500%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Coenzyme Q-10100 mg--
Beet Root Extract, Powder200 mg--

Other ingredients: Tapioca Syrup, Cane Sugar, Water, Natural Flavors, Pectin, Malic Acid, Sodium Citrate, Citric Acid, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We heart you! Pretty un-beet-able if you ask us!

Goli Nutrition is an inventive, people-focused nutrition company driven by the belief that happiness and wellness go hand in hand. We strive to provide innovative products, uniquely formulated with complementary ingredients all backed by science, in a delivery format that makes taking your daily supplements enjoyable!

Facebook / Instagram / Twitter @golinutrition #golinutrition www.goli.com/beetscardio

Formula

These delicious little gummies are made with CoQ10 to help support cardiovascular health. They also contain Vitamin B12 to support heart healthy cellular energy, as well as Beet Root Extract, one of nature's great superfoods. Now that's a formula to be pumped about

Beets Cardio Gummies 100 mg CoQ10 per serving Beet Root Powder Extract & Vitamin B12

Formulation

Gluten-Free Non-GMO Gelatin-Free

Vegan

Made in a FDA registered and cGMP certified facility in the U.S.A.

Nature's Great Superfood CoQ10 to support Heart Health B12 to support cellular Energy Production

Does not contain: yeast, wheat, eggs, gluten, soy, gelatin, peanuts, shellfish, dairy, synthetic colors, agave, and salicylates.

Storage

Store in a cool, dry place after opening.

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Warning: Consult a physician prior to use if pregnant or nursing, taking any medications or have any medical conditions.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 gummies, once daily. Chew thoroughly.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beets Cardio Gummies by Goli Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beets Cardio Gummies label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beets Cardio Gummies by Goli Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Vitamin B12

Interacts with
20 drugs
12 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Coenzyme Q-10

Interacts with
198 drugs
100 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q-10 monograph & interactions

Beet Root Extract, Powder

Interacts with
861 drugs
200 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet Root Extract, Powder monograph & interactions

Other (inactive) ingredients: Tapioca Syrup, Cane Sugar, Water, Natural Flavors, Pectin, Malic Acid, Sodium Citrate, Citric Acid, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beets Cardio Gummies by Goli Nutrition Drug Interactions

Want to check YOUR meds against Beets Cardio Gummies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
913Drugs
822 Moderate 91 Minor

Ingredients driving the most interactions

Beet Root Extract, Powder 861
Sodium 205
Coenzyme Q-10 198
Vitamin B12 20

Individual Drug Interactions

The ingredients in Beets Cardio Gummies interact with 913 drugs. Click any drug to see the details.

4 of the 4 ingredients in Beets Cardio Gummies interact with drugs. Each result below shows which ingredient is responsible. Beet Root Extract, Powder Sodium Coenzyme Q-10 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Beets Cardio Gummies with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet Root Extract, Powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet Root Extract, Powder full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Coenzyme Q-103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q-10 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beets Cardio Gummies, from the product label.

Goli Nutrition

See all Goli Nutrition products
Name
Goli Nutrition Inc.
City
West Hollywood
State
CA
ZipCode
90069
Phone Number
1-888-345-1452
Web Address
www.goli.com
Pharmacist Counseling Corner

Beets Cardio Gummies by Goli Nutrition: Common Questions

Does Beets Cardio Gummies by Goli Nutrition interact with any medications?
Yes. Based on its ingredients, Beets Cardio Gummies has a known interaction with 913 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beets Cardio Gummies contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will these gummies help my heart?
Beet extract is possibly effective for athletic performance and exercise-related soreness, but evidence for general heart health is not clearly established in our data. If you have a specific condition like heart failure or high blood pressure, check with your doctor—these gummies are a supplement, not a treatment.
Are there any side effects I should know about?
Most people tolerate these well. The main ones to watch for are red or black stools from the beet (harmless), and rare gastrointestinal upset from CoQ10. Sodium can worsen high blood pressure or heart strain if your intake is already high; check with your doctor if you're on a low-sodium diet.
Is it safe to take if I'm pregnant or breastfeeding?
Vitamin B12 and beet are fine at normal amounts during pregnancy and breastfeeding. Sodium safety during pregnancy has conflicting data—follow your provider's advice on sodium intake. CoQ10 and beet safety during breastfeeding hasn't been well studied; talk with your doctor before using.
Can I take these with my blood pressure medication?
Both sodium and CoQ10 in this product may interact with blood pressure drugs. Sodium can reduce how well they work; CoQ10 may add to their effect. Check your specific medication with your pharmacist before starting—don't skip this step.
What is CoQ10 and why is it in here?
CoQ10 is an antioxidant your body naturally makes for cell energy. It's included because some research suggests it may help with heart and muscle function, though evidence for heart health in healthy people isn't clear. If you take chemotherapy or warfarin, this ingredient is a concern.
Will the sodium in these gummies raise my blood pressure?
These gummies contain sodium that counts toward your daily total. If you already eat a typical Western diet, you're likely getting enough sodium—adding more from supplements can worsen blood pressure, especially if you have high blood pressure or heart disease. Ask your doctor if it fits your sodium budget.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Beets Cardio Gummies is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beets Cardio Gummies label
Go deeper

The Full Monographs Behind Beets Cardio Gummies’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph →
Sources

Sources & How We Checked

Beets Cardio Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
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Vitamin B12 30 references
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Coenzyme Q10 40 references
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Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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