Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Beta-Alanine Powder Unflavored Ingredients & Drug Interactions

by Optimum Nutrition

Beta-Alanine Powder Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beta-Alanine Powder Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Beta-Alanine Powder Unflavored is a dietary supplement by Optimum Nutrition with 6 active ingredients. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.Based on those ingredients, 467 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Beta-Alanine Powder Unflavored by Optimum Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Beta-Alanine Powder Unflavored by Optimum Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Beta-Alanine Powder Unflavored by Optimum Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 6 ingredients, of which the active ones are L-Histidine, CarnoSyn (a branded form of beta-alanine), Potassium, Magnesium, Phosphorus, and Sodium. Silicon Dioxide is included as an inactive ingredient (an anti-caking agent).

Beta-alanine is the main amino acid in this product — it's marketed for athletic performance. L-Histidine is another amino acid.

Potassium, Magnesium, Phosphorus, and Sodium are minerals that support various body functions including muscle and nerve signaling.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle stamina and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Exercise-induced muscle soreness, Physical performance, muscle endurance, high-intensity exercise capacity — and 1 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: Magnesium is rated "Possibly Ineffective" for Athletic performance.

Beta-alanine (CarnoSyn) is possibly effective for athletic performance and physical performance — the evidence suggests it may help, but it's not airtight. The data doesn't establish effectiveness for cognitive decline, COPD, cognitive function, or menopausal symptoms.

L-Histidine is possibly effective for cholera, but for eczema, kidney failure, and rheumatoid arthritis the evidence is too thin to rate. Magnesium is effective for indigestion and constipation, and also effective for preventing pre-eclampsia in pregnancy and treating low magnesium levels.

Sodium and Potassium effectiveness ratings are for conditions outside the scope of what this product is marketed for.

The evidence, ingredient by ingredient Histidine Beta-alanine Potassium Magnesium Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-alanine is generally well tolerated but causes a very common and harmless side effect: skin tingling and flushing, usually starting on the scalp within 20 minutes and lasting about an hour. This is dose-dependent — mild at lower amounts, more noticeable at higher ones.

The safety data doesn't cover long-term use at high doses. L-Histidine safety at supplement doses hasn't been well studied; dietary amounts are safe.

Magnesium and potassium can cause nausea, vomiting, diarrhea, and stomach pain at oral doses. Magnesium is generally well tolerated otherwise.

Sodium is safe in normal amounts but too much is linked to high blood pressure and heart strain over time. Avoid beta-alanine and potassium in pregnancy; magnesium and L-Histidine are likely safe; sodium is possibly unsafe in pregnancy.

For breastfeeding, there isn't enough data on beta-alanine or L-Histidine — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Histidine Beta-alanine Potassium Magnesium Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Potassium, Magnesium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 467 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take: levodopa/carbidopa (Sinemet) — magnesium significantly reduces how much gets into your bloodstream; skeletal muscle relaxants, blood pressure medications, heart or kidney drugs, diabetes medications, or antibiotics — magnesium, potassium, and sodium all affect these differently depending on which drugs you're on. No interactions are documented for beta-alanine or L-Histidine in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may appeal to athletes looking for a performance boost from beta-alanine, but the main reason to be careful is its mineral content — particularly if you take blood pressure drugs, heart medications, or diabetes medications. Before you start, check your exact prescriptions with your doctor or pharmacist, especially if you use levodopa (Parkinson's), muscle relaxants, or anything for blood pressure or heart rhythm.

If you're pregnant, breastfeeding, or have kidney disease, talk it over with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta-Alanine Powder Unflavored, straight from the product label.

Brand Optimum Nutrition
Barcode (UPC) 748927020946
Net contents 7.15 Ounce(s); 203 Gram(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 270137
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta-Alanine Powder Unflavored by Optimum Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.7 Gram(s)
Maximum serving Sizes:
2.7 Gram(s)
Servings per container
75
UPC/BARCODE
748927020946
IngredientAmount% DV
L-Histidine550 mg--
CarnoSyn1.6 Gram(s)--
Potassium55 mg2%
Magnesium15 mg4%
Phosphorus70 mg7%
Sodium20 mg1%

Other ingredients: Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The true strength of muscle stamina During high-intensity training, glucose and glycogen are broken down for energy. In the process, hydrogen ions (H+) are also produced within the muscles. H+ accumulation causes the muscle to become more acidic and ultimately leads to fatigue. The beta-alanine, histidine, and phosphates our Beta-Alanine Powder formula are designed to help support your intramuscular buffering system to help you so you can train harder, longer.

1.6 g beta alanine

General Statements

True Strength www.optimumnutrition.com ON Serving scoop included, but may settle to the bottom during shipping

Contents sold by weight not volume.

Suggested/Recommended/Usage/Directions

Directions: Add 1 scoop of Beta-Alanine Powder to a glass or shaker cup filled with 6-8 oz. of cold water or your favorite beverage. Mix or shake thoroughly for 15-20 seconds or until completely dissolved. Suggested Use: Consume one serving first thing in the morning and a second serving approximately 30 minutes before your workout (or mid-afternoon on non-training days). Intended for use in healthy adults as part of a healthy, balanced diet and exercise program.

Precautions

Warning: Consult your physician before using this product if you are taking any medications or are under a physician's care for a medical condition. Not for the use by those under the age of 18 or women that are pregnant, trying to get pregnant or nursing or those that are sensitive to beta-alanine.

Not for the use by those under the age of 18 or women that are pregnant, trying to get pregnant or nursing or those that are sensitive to beta-alanine.

Beta-alanine may cause harmless, temporary tingling or flushing sensation.

Storage

Store tightly-closed container in a cool, dry place.

Formulation

Endurance support

0 g sugar

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

CarnoSyn Carnosine Synthesizer CarnoSyn trademark and patents owned by Natural Alternatives International, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beta-Alanine Powder Unflavored by Optimum Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beta-Alanine Powder Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beta-Alanine Powder Unflavored by Optimum Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.7 Gram(s) Dosage formPowder Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Histidine

No known
interactions
550 mg per serving

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...

L-Histidine monograph & interactions

CarnoSyn

No known
interactions
1.6 Gram(s) per serving Form: Beta-Alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

CarnoSyn monograph & interactions

Potassium

Interacts with
62 drugs
55 mg per serving Form: Dipotassium Phosphate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Magnesium

Interacts with
295 drugs
15 mg per serving Form: Dimagnesium Phosphate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Phosphorus

70 mg per serving Form: dimagnesium phosphate, Dipotassium Phosphate, monosodium phosphate

Sodium

Interacts with
205 drugs
20 mg per serving Form: monosodium phosphate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Other (inactive) ingredients: Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta-Alanine Powder Unflavored by Optimum Nutrition Drug Interactions

Want to check YOUR meds against Beta-Alanine Powder Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
467Drugs
6 Major 352 Moderate 109 Minor

Ingredients driving the most interactions

Magnesium 295
Sodium 205
Potassium 62

Individual Drug Interactions

The ingredients in Beta-Alanine Powder Unflavored interact with 467 drugs. Click any drug to see the details.

3 of the 6 ingredients in Beta-Alanine Powder Unflavored interact with drugs. Each result below shows which ingredient is responsible. Magnesium Sodium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta-Alanine Powder Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beta-Alanine Powder Unflavored, from the product label.

Optimum Nutrition

Name
Optimum Nutrition
Street Address
975 Meridian Lake Dr.
City
Aurora
State
IL
ZipCode
60504
Web Address
www.optimumnutrition.com
Pharmacist Counseling Corner

Beta-Alanine Powder Unflavored by Optimum Nutrition: Common Questions

Does Beta-Alanine Powder Unflavored by Optimum Nutrition interact with any medications?
Yes. Based on its ingredients, Beta-Alanine Powder Unflavored has a known interaction with 467 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta-Alanine Powder Unflavored contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's that tingling feeling I get after taking beta-alanine?
That's paresthesia — a harmless pins-and-needles sensation, usually with skin flushing. It starts on your scalp about 20 minutes after you take it and spreads across your body, lasting roughly an hour. It's dose-dependent, so smaller amounts cause mild tingling or none at all, and higher doses cause more noticeable tingling. It's not dangerous, just a normal side effect of beta-alanine.
Does beta-alanine actually work for athletic performance?
The evidence says it's possibly effective — meaning research suggests it may help, but the data isn't conclusive. It's worth a trial if you're an athlete, but results vary from person to person.
Is this safe during pregnancy?
Beta-alanine is not recommended in pregnancy — there isn't enough safety data. L-Histidine and magnesium are likely safe, and sodium is likely safe too, but potassium should be avoided. Talk with your doctor before taking any supplement during pregnancy for personalized advice.
Can I take this with my blood pressure medication?
That depends on which medication you take. Sodium and potassium in this powder can reduce how well some blood pressure drugs work or raise your potassium to unsafe levels, depending on the type. Show your doctor or pharmacist a list of what you take — don't start without checking first.
What does L-Histidine do in this product?
L-Histidine is an amino acid. The evidence suggests it may help with cholera, but for other uses like eczema or arthritis the evidence is too weak to know if it works. The safety data at supplement doses is also limited.
What are the inactive ingredients?
Silicon dioxide is the only inactive ingredient listed — it's an anti-caking agent to keep the powder from clumping.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta-Alanine Powder Unflavored label
Go deeper

The Full Monographs Behind Beta-Alanine Powder Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Beta-Alanine Powder Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 148 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
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  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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