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Dietary supplement

Betaine Ingredients & Drug Interactions

by Highland Laboratories

Betaine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Betaine is a dietary supplement by Highland Laboratories with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Betaine by Highland Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine by Highland Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Betaine by Highland Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This 2-ingredient product combines betaine hydrochloride, which is hydrochloric acid bonded to betaine and designed to increase stomach acid, and acid protease, a digestive enzyme. The remaining ingredients are vegetable cellulose, cellulose, silica, magnesium stearate, and chlorophyll—these are inactive ingredients that form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: stomach acid support for digestion.
  • We looked for evidence on: Dyspepsia, hypochlorhydria, indigestion, gastric acid insufficiency.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence on betaine HCl isn't established in our data. It's been studied for several conditions—dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, and allergic rhinitis—but none have sufficient reliable evidence to support its use.

Acid protease effectiveness data isn't on file for this product either.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine HCl may irritate your stomach and isn't safe if you have ulcers, gastritis, or true acid reflux—the acid it produces could worsen these conditions or cause heartburn. Acid protease is generally well tolerated for most adults but may occasionally cause digestive upset or allergic reactions; people with sensitivity to protease enzymes (sometimes seen in those exposed to laundry enzymes) should be cautious.

For pregnancy, the safety data advises against betaine HCl—there isn't enough information to know it's safe. Acid protease should also be avoided in pregnancy unless a doctor prescribes it.

During breastfeeding, there isn't enough data for betaine HCl, so medical advice is needed before using it; acid protease is also not recommended during breastfeeding without guidance from your doctor or pharmacist.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on H2-blockers, antacids, or proton pump inhibitors—betaine HCl may reduce how well these work. No interactions are documented for acid protease in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is designed to increase stomach acid, so it's only an option if you have low acid (not high). If you take any acid-reducing medication or have ulcers or reflux, skip it—and talk with your own doctor or pharmacist before starting, especially to confirm your stomach acid is actually low and that neither ingredient will cause problems with your other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine, straight from the product label.

Brand Highland Laboratories
Barcode (UPC) 768305509108
Net contents 100 Vegetarian ChloroCap(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79515
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine by Highland Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian ChloroCap(s)
Maximum serving Sizes:
1 Vegetarian ChloroCap(s)
UPC/BARCODE
768305509108
IngredientAmount% DV
Acid Protease130 mg--
Betaine HCl649 mg--

Other ingredients: Vegetable Cellulose, Cellulose, Silica, Magnesium Stearate, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Also available in 200 & 500 count

% Daily Value

Formula

With Chlorophyll capsules

Betaine Hydrochloric Acid

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Quality Assured Earth Friendly

Formulation

No corn, soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives.

Suggested/Recommended/Usage/Directions

One to two capsules with or immediately following a meal, as a dietary supplement. As a supplemental source of hydrochloric acid, best taken with a small amount of water.

Brand IP Statement(s)

ChloroCaps are a natural plant based capsule containing chlorophyll.

General

PR 509

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine by Highland Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine by Highland Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian ChloroCap(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acid Protease

No known
interactions
130 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Acid Protease monograph & interactions

Betaine HCl

Interacts with
36 drugs
649 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Cellulose, Silica, Magnesium Stearate, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine by Highland Laboratories Drug Interactions

Want to check YOUR meds against Betaine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Betaine interact with 36 drugs. Click any drug to see the details.

1 of the 2 ingredients in Betaine interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Betaine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Betaine, from the product label.

Highland Laboratories

See all Highland Laboratories products
Name
Highland Laboratories
Pharmacist Counseling Corner

Betaine by Highland Laboratories: Common Questions

Does Betaine by Highland Laboratories interact with any medications?
Yes. Based on its ingredients, Betaine has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Betaine contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does acid protease do?
Acid protease is a digestive enzyme—it breaks down proteins in your stomach. We don't have effectiveness data on file for this ingredient in this product, so we can't say how well it works.
Can I take this if I have acid reflux?
No—betaine HCl increases stomach acid and isn't safe for people with acid reflux or heartburn. It could irritate your stomach further and make symptoms worse. Talk with your doctor or pharmacist about what's actually right for your situation.
Is it safe during pregnancy?
The safety data advises against both ingredients during pregnancy—there isn't enough information to know they're safe. Talk with your doctor or pharmacist about whether you should take this while pregnant.
Could this cause digestive upset?
Yes. Betaine HCl may cause heartburn or stomach irritation, and acid protease may occasionally cause digestive upset or allergic reactions in some people.
What is betaine HCl?
It's hydrochloric acid bonded to betaine, an amino acid. This form is designed to increase the acid in your stomach—it's used only when stomach acid is too low, not high.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine label
Go deeper

The Full Monographs Behind Betaine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Betaine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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