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Dietary supplement

Betaine HCL 650 mg Ingredients & Drug Interactions

by Good State

Betaine HCL 650 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine HCL 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Betaine HCL 650 mg is a dietary supplement by Good State with 2 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine HCl, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Betaine HCL 650 mg by Good State

Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine HCL 650 mg by Good State — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Betaine HCL 650 mg by Good State

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: papain and betaine HCl. Papain is an enzyme from papaya fruit; it's traditionally used to support digestion and tissue health, though reliable evidence for those uses is limited in our data.

Betaine HCl is a compound form of betaine paired with hydrochloric acid, included to increase stomach acid and theoretically improve how your digestive system breaks down food. The product also contains two inactive ingredients — ascorbyl palmitate and vegetable cellulose — which serve as a preservative and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: healthy brain function, digestion, heart and liver.
  • We looked for evidence on: Dyspepsia, Hyperhomocysteinemia, indigestion, gastric acid support, cardiovascular health.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Hyperhomocysteinemia.

The evidence we hold does not establish that papain works for any of the conditions listed on supplements — cancer, dental cavities, skin damage from radiation, exercise soreness, shingles, or parasite infection all show insufficient reliable evidence. Similarly, betaine HCl does not have established evidence for dyspepsia (indigestion), low thyroid function, diarrhea, rheumatoid arthritis, food allergies, or hay fever.

If you're considering this product for a specific reason, talk with your pharmacist or doctor about what the science actually supports.

The evidence, ingredient by ingredient Papain Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated when you take it short-term at normal doses, but it can irritate your digestive tract and trigger allergic reactions in sensitive people — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. High doses may be unsafe and are linked to serious but rare risks like esophageal perforation and severe inflammation of the stomach lining.

Papain is not safe during pregnancy and there isn't enough data to know whether it's safe while breastfeeding. Betaine HCl can irritate your stomach and should be avoided if you have ulcers, gastritis, or true acid reflux — it may trigger heartburn or worsen ulcers.

There is not enough safety information to use it during pregnancy or while breastfeeding, so both should be avoided.

Side effects, ingredient by ingredient Papain Betaine Hydrochloride

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your pharmacist if you take warfarin — papain may raise your blood-thinning level. Also check if you take any stomach-acid medications: H2-blockers like famotidine, antacids, or proton pump inhibitors (PPIs) — betaine HCl may reduce how well these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people interested in digestive enzyme support, but the evidence for its uses is not established in our data. If you take warfarin or any stomach-acid medication (H2-blockers, antacids, or PPIs), you'll need to check with your pharmacist first.

Do not use it if you have ulcers, gastritis, or true acid reflux, and avoid it during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine HCL 650 mg, straight from the product label.

Brand Good State
Barcode (UPC) 857515003541
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276914
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine HCL 650 mg by Good State, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
857515003541
IngredientAmount% DV
Papain150 mg--
Betaine HCl650 mg--

Other ingredients: Ascorbyl Palmitate, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Good State's Betaine HCL may be beneficial for healthy brain function, improve digestion, heart, and liver function.

Good State is proud to follow Good Manufacturing Practices (GMP)

Formulated to help Balance your stomach's pH level

Professional grade

General Statements

Remember, for a good state of health, give your body what it needs!

Note: No product claims are being made or implied. Research is ongoing.

100% Satisfaction guaranteed

Give your body what it needs! Health solutions

Text support +1-215-608-1124

X000N1LYPH FBA USA UPC 857515003541

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Contains 650 mg Betaine HCL

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults:Take one capsule (650 mg) with a protein- enriched meal. Results will vary.

Shake well before using.

Precautions

Children: Consult a physician. Caution: Keep out of reach of children.

Always speak with your physician before using any dietary supplement.

Do not use if tamper-evident seal is broken or missing.

Storage

For freshness, keep refrigerated after opening, or store in a cool, dark place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine HCL 650 mg by Good State label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine HCL 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine HCL 650 mg by Good State

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
150 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Betaine HCl

Interacts with
36 drugs
650 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Other (inactive) ingredients: Ascorbyl Palmitate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine HCL 650 mg by Good State Drug Interactions

Want to check YOUR meds against Betaine HCL 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betaine HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Betaine HCL 650 mg interact with 38 drugs. Click any drug to see the details.

2 of the 2 ingredients in Betaine HCL 650 mg interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Betaine HCL 650 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Betaine HCL 650 mg, from the product label.

Good State

Name
GoodState, Inc.
Street Address
575 Virginia Drive, Suite C
City
Fort Washington
State
PA
ZipCode
19034
Phone Number
1-866-227-6097
Web Address
www.GoodState.com
Pharmacist Counseling Corner

Betaine HCL 650 mg by Good State: Common Questions

Does Betaine HCL 650 mg by Good State interact with any medications?
Yes. Based on its ingredients, Betaine HCL 650 mg has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Betaine HCL 650 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is papain and why is it in this product?
Papain is an enzyme from papaya fruit included to support digestion. However, the evidence we hold does not show it reliably works for any specific condition, so talk with your pharmacist about whether it's right for your needs.
Can I take this if I have heartburn or acid reflux?
No. Betaine HCl is not safe if you have ulcers, gastritis, or true acid reflux — it increases stomach acid and may trigger heartburn or make ulcers worse. If you think you have acid reflux, talk with your doctor before trying this product.
Is papain safe if I'm pregnant or breastfeeding?
No. Papain is possibly unsafe in pregnancy due to safety concerns, and there isn't enough data to know whether it's safe while breastfeeding. Betaine HCl also should be avoided during both pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are the side effects of papain?
Most commonly, papain can cause allergic reactions — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea — in people sensitive to it. High doses carry a rare risk of serious digestive damage. Stop taking it and call your doctor if you have any of these symptoms.
Can I take this with my H2-blocker or antacid?
Not at the same time. Betaine HCl increases stomach acid and can make those medications less effective. Talk with your pharmacist about the best timing or whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine HCL 650 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine HCL 650 mg label
Go deeper

The Full Monographs Behind Betaine HCL 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Betaine HCL 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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