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Dietary supplement

Betaine Plus Ingredients & Drug Interactions

by Martin Avenue Pharmacy

Betaine Plus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Betaine Plus is a dietary supplement by Martin Avenue Pharmacy with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are from 650 mg Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Betaine Plus by Martin Avenue Pharmacy

Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine Plus by Martin Avenue Pharmacy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Betaine Plus by Martin Avenue Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Betain” is listed as a grouped ingredient — the label gives one combined amount (496 mg) without saying how much of each component you get.

Betaine Plus contains two active ingredients. Pepsin is a proteolytic enzyme — a protein-digesting enzyme — that works to break down proteins in food during digestion.

Betaine hydrochloride (650 mg per serving) is a form of betaine, a naturally occurring compound involved in metabolism and stomach acid production. The capsule also contains inactive ingredients: cellulose, gelatin, and vegetable stearate — these are fillers and binders that hold the capsule together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish whether betaine hydrochloride is effective for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, or allergic rhinitis. The data rates all of these as insufficient evidence to rate.

Pepsin has no effectiveness ratings in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated for most adults but may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to airborne pepsin has caused allergic rhinitis or asthma in sensitive individuals.

Betaine hydrochloride may irritate the stomach and is not safe for people with ulcers, gastritis, or true acid reflux — it can theoretically worsen those conditions or cause heartburn. During pregnancy, safety data for betaine hydrochloride is not established, so it is best avoided unless prescribed by your doctor.

Safety during breastfeeding has not been established either, so avoid use without medical advice. For pepsin, there is little safety data during breastfeeding, so use is not recommended without medical advice, and safety has not been established in pregnancy unless prescribed.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (like omeprazole, lansoprazole, or pantoprazole), check with your doctor or pharmacist before using this product — betaine hydrochloride may reduce their effectiveness. No interactions are documented for pepsin with any medications in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Betaine Plus might appeal to someone looking for digestive enzyme support, but the evidence we hold doesn't yet establish whether it works for common conditions. If you take any medication to reduce stomach acid — including antacids, H2-blockers, or PPIs — talk with your doctor or pharmacist before starting this product, since it could interfere with how those drugs work.

Anyone with a history of ulcers, gastritis, or acid reflux should also check with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine Plus, straight from the product label.

Brand Martin Avenue Pharmacy
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18786
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine Plus by Martin Avenue Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Pepsin140 mg--
Betain496 mg--
from 650 mg Betaine HCl650 mg--

Other ingredients: Cellulose, Gelatin, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take as directed by a physician only.

Precautions

Keep out of reach of children.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59-77degF/15-25degC) (35-65% relative humidity)

General Statements

"We Make It Better..."

QUALITY AND POTENCY GUARANTEED

General

#10013

FDA Statement of Identity

Dietary Supplement

Formula

Digestive Enzyme Formula with Pepsin

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine Plus by Martin Avenue Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine Plus by Martin Avenue Pharmacy

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pepsin

No known
interactions
140 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betain

496 mg per serving

Other (inactive) ingredients: Cellulose, Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine Plus by Martin Avenue Pharmacy Drug Interactions

Want to check YOUR meds against Betaine Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

from 650 mg Betaine HCl 36

Individual Drug Interactions

The ingredients in Betaine Plus interact with 36 drugs. Click any drug to see the details.

1 of the 2 ingredients in Betaine Plus interact with drugs. Each result below shows which ingredient is responsible. from 650 mg Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Betaine Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

from 650 mg Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
from 650 mg Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Betaine Plus, from the product label.

Martin Avenue Pharmacy

See all Martin Avenue Pharmacy products
Name
Martin Avenue Pharmacy, Inc.
City
Naperville
State
IL
ZipCode
60540
Phone Number
(630) 355-6400
Pharmacist Counseling Corner

Betaine Plus by Martin Avenue Pharmacy: Common Questions

Does Betaine Plus by Martin Avenue Pharmacy interact with any medications?
Yes. Based on its ingredients, Betaine Plus has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Betaine Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does pepsin do in this product?
Pepsin is a protein-digesting enzyme that helps break down proteins in your food during digestion. It's a proteolytic enzyme — that means it cuts protein molecules into smaller pieces your body can absorb more easily.
Can I take this if I have an ulcer or acid reflux?
No. Betaine hydrochloride raises stomach acid and is not safe for people with ulcers, gastritis, or true acid reflux. It could irritate those conditions or delay healing. Talk to your doctor first.
Is this safe during pregnancy?
The safety data for betaine hydrochloride is not established in pregnancy, so it's best avoided unless your doctor prescribes it. Pepsin safety hasn't been established in pregnancy either. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to be.
Can I take this while breastfeeding?
Safety data during breastfeeding is not established for either ingredient in this product. Both are best avoided without medical advice. Check with your doctor or pharmacist if you're breastfeeding.
What are the side effects?
Pepsin is generally well tolerated but may cause digestive upset or allergic reactions in some people. Betaine hydrochloride may cause stomach irritation or heartburn. In rare cases, exposure to pepsin can trigger allergic rhinitis or asthma in sensitive individuals.
Does this work for indigestion?
The evidence we hold rates betaine hydrochloride's effectiveness for indigestion (dyspepsia) as insufficient — we don't yet have reliable data showing whether it works for that. Your doctor or pharmacist can discuss whether it might be right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine Plus label
Go deeper

The Full Monographs Behind Betaine Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Betaine Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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