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Dietary supplement

Biotic Supreme 50 Ingredients & Drug Interactions

by Neurobiologix

Biotic Supreme 50 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biotic Supreme 50 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biotic Supreme 50 is a dietary supplement by Neurobiologix with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biotic Supreme 50 by Neurobiologix

Ask about any prescription or over-the-counter medication and we check it for interactions with Biotic Supreme 50 by Neurobiologix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biotic Supreme 50 by Neurobiologix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (323 mg) without saying how much of each component you get.

Biotic Supreme 50 contains 8 active ingredients, all probiotics or prebiotic fibers meant to support your gut bacteria. The two we have detailed safety and interaction data for are Lactobacillus acidophilus and Bifidobacterium bifidum, both live-culture strains.

The product also includes Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus, Lactobacillus reuteri, and Sunfiber (a prebiotic fiber). The capsule itself contains inactive ingredients like hydroxypropyl methylcellulose, gellan gum, water, silica, and ascorbyl palmitate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Respiratory tract infections — rated "Possibly Effective" (Bifidobacterium Bifidum) (Natural Medicines).

For Lactobacillus acidophilus, the evidence suggests it may help with irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis — all rated possibly effective. It's rated possibly ineffective for atopic disease, and there's insufficient evidence to rate it for acute respiratory distress syndrome.

Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections, though evidence is insufficient for allergic rhinitis (hay fever), Alzheimer disease, and generalized anxiety disorder. We don't have effectiveness ratings on file for the other active ingredients in this formula.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though data are limited — check with your doctor before use. Bifidobacterium bifidum is generally well tolerated in healthy people, but those with weakened immune systems should be cautious, and evidence is limited, so consult your doctor first.

Both are rated possibly safe in pregnancy. Gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and diarrhea can occur but are uncommon.

Rarely, live probiotics have been associated with serious infections like bacteremia or sepsis, though this is typically in people with serious underlying illness or compromised immunity. A rash with itching was reported in one trial, though it's unclear whether the probiotics caused it.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern (Moderate severity) — the live probiotics in this product can be killed off by antibiotics taken at the same time, which may reduce how well the probiotics work. Space them out by a few hours.

For the other ingredients in this formula (Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus, Lactobacillus reuteri, and Sunfiber), we hold no interaction data, so check with your pharmacist about any medications you take.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic blend may be worth considering if you have IBS, antibiotic-related diarrhea, or certain other gut or respiratory concerns — the two main strains have some supporting evidence. If you take antibiotics, you'll need to space them out from this product.

Anyone with a weakened immune system should talk to their doctor before starting. Check your exact medications with the tool on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biotic Supreme 50, straight from the product label.

Brand Neurobiologix
Barcode (UPC) 858104006622
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 327660
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biotic Supreme 50 by Neurobiologix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
858104006622
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus paracasei0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium animalis lactis0 NP--
Probiotic Blend323 mg--
Lactobacillus rhamnosus0 NP--
Lactobacillus reuteri0 NP--
Sunfiber200 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Gellan Gum, Water, Silica, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Probiotic complex

Suggested/Recommended/Usage/Directions

Suggested use: Adults: 1 capsule daily or as directed by a healthcare professional.

Precautions

Children: As directed by a healthcare professional.

Do not use if shrinkwrap is broken or missing.

Keep out of reach of children.

In case of adverse reaction, call 866-500-5388.

Professional use only

Brand IP Statement(s)

Sunfiber, a water-soluble dietary fiber, is a registered trademark of Taiyo International, Inc.

Formula

Sunfiber, a water-soluble dietary fiber, is a registered trademark of Taiyo International, Inc.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biotic Supreme 50 by Neurobiologix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biotic Supreme 50 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biotic Supreme 50 by Neurobiologix

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Probiotic Blend

Interacts with
182 drugs
323 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Sunfiber

200 mg per serving Form: Guar Gum, Partially Hydrolyzed

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Gellan Gum, Water, Silica, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biotic Supreme 50 by Neurobiologix Drug Interactions

Want to check YOUR meds against Biotic Supreme 50?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Biotic Supreme 50 interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Biotic Supreme 50 interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Biotic Supreme 50 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biotic Supreme 50, from the product label.

Neurobiologix

See all Neurobiologix products
Name
Neurobiologix, Inc.
Street Address
13376 N. Hwy 183, Ste 126
City
Austin
State
TX
ZipCode
78750
Phone Number
866-500-5388
Web Address
www.neurobiologix.com
Pharmacist Counseling Corner

Biotic Supreme 50 by Neurobiologix: Common Questions

Does Biotic Supreme 50 by Neurobiologix interact with any medications?
Yes. Based on its ingredients, Biotic Supreme 50 has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biotic Supreme 50 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time. Both Lactobacillus acidophilus and Bifidobacterium bifidum in this product are live organisms, and antibiotics will kill them off, making the probiotics less effective. Separate when you take them — ask your pharmacist for a specific timing plan based on your antibiotic.
Is this safe to take while pregnant or breastfeeding?
The two main ingredients, Lactobacillus acidophilus and Bifidobacterium bifidum, are rated possibly safe in pregnancy. However, data on the other ingredients and on breastfeeding are limited or not on file. Talk with your doctor or pharmacist before starting, especially if you're breastfeeding.
Will this help my IBS?
Both Lactobacillus acidophilus and Bifidobacterium bifidum are rated possibly effective for IBS, meaning some evidence supports their use, but it's not yet conclusive. Results vary from person to person, so check with your doctor about whether it's right for you.
What side effects might I experience?
Gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and diarrhea can occur but are uncommon. A rash with itching was reported in one trial, though it's unclear if the probiotics caused it. Most people tolerate it well.
What is Sunfiber, and why is it in this product?
Sunfiber is a prebiotic fiber — it feeds the beneficial bacteria in your gut rather than being a live organism itself. We don't have detailed data on file for it, but prebiotic fibers are often combined with probiotics to support their growth and function.
Is this product safe if I have a weakened immune system?
Bifidobacterium bifidum specifically cautions that people with weakened immune systems should be cautious. Since live probiotics can rarely cause serious infections in people with compromised immunity, talk with your doctor before starting if your immune system is not fully healthy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Biotic Supreme 50 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biotic Supreme 50 label
Go deeper

The Full Monographs Behind Biotic Supreme 50’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Biotic Supreme 50's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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