Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Biotix-40 Ingredients & Drug Interactions

by Millecor

Biotix-40 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biotix-40 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biotix-40 is a dietary supplement by Millecor with 6 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (La-14). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biotix-40 by Millecor

Ask about any prescription or over-the-counter medication and we check it for interactions with Biotix-40 by Millecor — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biotix-40 by Millecor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend of Probiotic Bacteria MAKTREK” is a proprietary blend — the label doesn't break down how much of each component you get.

Biotix-40 contains six active ingredients: three species of Lactobacillus bacteria (paracasei, acidophilus, and plantarum), Bifidobacterium lactis, fructooligosaccharide (a type of fiber that feeds beneficial bacteria), and a marine polysaccharide complex. The bacteria and fiber work together as a probiotic supplement — the live organisms aim to support your gut flora, and the prebiotic fiber helps feed them.

The capsule also contains inactive ingredients: cellulose, rice maltodextrin, and L-leucine. These are fillers and binders that hold the formula together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy digestion and intestinal integrity.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation.

The evidence for this product's ingredients is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis.

Fructooligosaccharide has insufficient evidence to rate it for constipation, diabetes, osteoporosis, high cholesterol, or travelers' diarrhea — meaning the research so far hasn't been robust enough to draw firm conclusions. We don't have effectiveness data on file for the other bacterial strains in this product.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Fructooligosaccharide commonly causes gas, bloating, flatulence, and abdominal pain, especially at higher doses, though a meta-analysis of clinical trials found these effects don't necessarily happen more often than with placebo at doses under 10 grams per day.

Both ingredients have limited safety data at supplement levels, so check with your doctor before starting, especially if you have a compromised immune system or other health concerns. Pregnancy data for Lactobacillus acidophilus is listed as possibly safe; we don't have lactation data on file.

We hold no pregnancy or lactation data for the other ingredients.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, you'll want to check timing with your pharmacist before starting this product, because Lactobacillus acidophilus may be less effective if you take them at the same time (Moderate severity). No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Biotix-40 is a multi-strain probiotic with a prebiotic fiber. It's generally well tolerated, though the fiber can cause bloating and gas.

The biggest medication caution is antibiotics — separate the timing if you're on them. If you take any prescriptions, run them through the checker here first, and talk to your pharmacist or doctor about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biotix-40, straight from the product label.

Brand Millecor
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261413
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biotix-40 by Millecor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus paracasei Lpc-370 NP--
Fructooligosaccharide0 NP--
Lactobacillus acidophilus (La-14)0 NP--
Lactobacillus plantarum (Lp-115)0 NP--
Marine Polysaccharide Complex0 NP--
Proprietary Blend of Probiotic Bacteria MAKTREK0 NP--
Bifidobacterium lactis (Bl-04)0 NP--

Other ingredients: Cellulose, Rice Maltodextrin, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Millecor Biotix-40 offers a balanced spectrum of live CFU. Probiotic bacteria are critical for healthy digestion, helping maintain the integrity of the intestinal lining, supporting proper intestinal motility, and participating in the detoxification process.

This product is formulated with 40 billion CFU per 2 caps and to deliver a minimum potency of 20 billion CFU per 2 caps through the best by date.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules once daily. For best results, take one (1) capsule during the day and one (1) capsule in the evening. Repeat the process daily. Do not exceed two capsules per day.

Storage

Keep refrigerated to maintain potency.

Store in a cool, dry place.

Precautions

Keep out the reach of children.

Do not use if safety seal is damaged or missing.

Do not exceed two capsules per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Probiotic 40 Billion CFU

General Statements

Veteran owned business

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Certified Good Manufacturing Practice Made in a FDA Registered Facility USA Made in America

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biotix-40 by Millecor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biotix-40 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biotix-40 by Millecor

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend of Probiotic Bacteria MAKTREK

0 NP per serving

Other (inactive) ingredients: Cellulose, Rice Maltodextrin, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biotix-40 by Millecor Drug Interactions

Want to check YOUR meds against Biotix-40?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (La-14) 182

Individual Drug Interactions

The ingredients in Biotix-40 interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Biotix-40 interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (La-14)

Each ingredient & the kinds of drugs it affects

For each ingredient in Biotix-40 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biotix-40, from the product label.

Millecor

See all Millecor products
Name
MILLECOR
Street Address
215 Gonyo Ln
City
Richmond
State
TX
ZipCode
77469
Web Address
MILLECOR.com
Pharmacist Counseling Corner

Biotix-40 by Millecor: Common Questions

Does Biotix-40 by Millecor interact with any medications?
Yes. Based on its ingredients, Biotix-40 has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biotix-40 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is fructooligosaccharide and why is it in this product?
It's a type of fiber that your gut bacteria feed on — it's a prebiotic. It's included because it works alongside the live probiotic organisms to support your gut flora. On its own, fructooligosaccharide can cause bloating and gas, especially at higher doses.
Will this give me gas or bloating?
Possibly, yes. Fructooligosaccharide commonly causes abdominal discomfort, bloating, and flatulence, especially when you first start taking it or if doses are high. Most people report these symptoms are mild, and they often settle down. A meta-analysis of clinical trials found that at doses under 10 grams per day, these side effects don't necessarily happen more often than with placebo.
Is this safe if I'm pregnant or breastfeeding?
Lactobacillus acidophilus is possibly safe in pregnancy, but we don't have lactation data on file for it or the other ingredients in this product. There isn't enough information to know if the other strains are safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice before taking it.
Can I take this with antibiotics?
Not at the same time. Because Lactobacillus acidophilus is made of live organisms, antibiotics can kill them off and make the probiotic less effective. Ask your pharmacist how far apart to space them — usually several hours is recommended.
What conditions does this product treat?
Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection. The fructooligosaccharide and other bacterial strains don't have strong enough evidence to say they work for constipation, diabetes, osteoporosis, or high cholesterol. This is a supplement, not a treatment for disease — talk to your doctor about whether it fits your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Biotix-40 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biotix-40 label
Go deeper

The Full Monographs Behind Biotix-40’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Biotix-40's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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