Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Birch Complex Cold Extraction Ingredients & Drug Interactions

by True Botanica

Birch Complex Cold Extraction label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Birch Complex Cold Extraction against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Birch Complex Cold Extraction is a dietary supplement by True Botanica with 2 active ingredients. Its ingredients are commonly taken for urinary tract and 'flushing' support, joint pain and arthritis, mild fluid retention (diuretic).Based on those ingredients, 75 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Birch Herb Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Birch Complex Cold Extraction by True Botanica

Ask about any prescription or over-the-counter medication and we check it for interactions with Birch Complex Cold Extraction by True Botanica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Birch Complex Cold Extraction by True Botanica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Birch Herb Extract” is listed as a grouped ingredient — the label gives one combined amount (0.25 mL) without saying how much of each component you get.

This liquid contains 2 active ingredients, both forms of birch. Birch Herb Extract and Birch (from Betula sp.) are the botanicals here; the rest — water, glycerin, apple cider vinegar, salts, trace minerals, potassium sorbate, and citric acid — are inactive ingredients that preserve and carry the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Birch product and its label doesn't state a use — see Birch's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for birch isn't established in the data we hold. For joint pain, alopecia (hair loss), and dandruff, the rating is insufficient reliable evidence to rate — meaning there's not enough solid research to say whether it works for these uses.

The evidence, ingredient by ingredient Birch

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Birch is generally well tolerated in food-like amounts, but allergy and quality concerns warrant caution. People with birch pollen allergies can have allergic reactions to the plant itself, and topical birch products have caused allergic contact dermatitis in some people — the compound betulin in birch bark appears to be a likely culprit.

Fresh birch sap and crushed leaves can also trigger contact dermatitis. The safety data advises against birch during pregnancy and while breastfeeding because there isn't enough research to know it's safe in those situations.

If you're pregnant, trying to conceive, or nursing, talk with your pharmacist or doctor before taking this product.

Side effects, ingredient by ingredient Birch

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Birch.
  • The most serious interaction on file is rated Minor.
  • For scale: 75 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diuretic drugs (water pills) — such as furosemide, hydrochlorothiazide, or spironolactone — check the full list of your medications below before starting this product. We couldn't fully check one of the ingredient names in our database, so running your exact drugs through the tool on this page is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Birch Complex is generally well tolerated for most people, but if you take water pills (diuretics), check with us first — this product may interfere with them. Anyone with a birch pollen allergy should be especially cautious.

Pregnant women and anyone nursing should avoid it unless they've talked with their pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Birch Complex Cold Extraction, straight from the product label.

Brand True Botanica
Net contents 55 mL; 1.86 Fluid Ounce(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 336206
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Birch Complex Cold Extraction by True Botanica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
55
IngredientAmount% DV
Birch Herb Extract0.25 mL--
Betula sp.35 mg--
Birch0.75 mL--

Other ingredients: Water, Distilled, Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested Usage: 20 drops (1 ml, 1/5 tsp) one to three times daily or as suggested by your health care provider.

Formulation

Made with alcohol free, rhythmical proprietary processes. Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame, soy, wheat, or gluten.

Cold Extraction Herbal Tincture

Precautions

Consult your health care provider before using this product if you are pregnant, lactating or have other medical concerns or compatibility issues.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Birch Complex Cold Extraction by True Botanica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Birch Complex Cold Extraction label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Birch Complex Cold Extraction by True Botanica

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container55 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Birch Herb Extract

Interacts with
75 drugs
0.25 mL per serving

Birch is a tree whose leaves, bark, and sap are used in traditional remedies, most often as a mild diuretic or for joint and urinary complaints. Solid...

Birch Herb Extract monograph & interactions
  • › Betula sp.

Birch

Interacts with
75 drugs
0.75 mL per serving

Birch is a tree whose leaves, bark, and sap are used in traditional remedies, most often as a mild diuretic or for joint and urinary complaints. Solid...

Birch monograph & interactions

Other (inactive) ingredients: Water, Distilled, Glycerin, Apple Cider Vinegar, Salts, Trace Minerals, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Birch Complex Cold Extraction by True Botanica Drug Interactions

Want to check YOUR meds against Birch Complex Cold Extraction?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
75Drugs
75 Minor

Ingredients driving the most interactions

Birch Herb Extract 75

Individual Drug Interactions

The ingredients in Birch Complex Cold Extraction interact with 75 drugs. Click any drug to see the details.

1 of the 2 ingredients in Birch Complex Cold Extraction interact with drugs. Each result below shows which ingredient is responsible. Birch Herb Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Birch Complex Cold Extraction with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Birch Herb Extract1 drug type · 75 drugs

Diuretic Drugs

Theoretically, birch might interfere with diuretic therapy.

Likelihood Possible Evidence D
Birch Herb Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Birch Complex Cold Extraction, from the product label.

True Botanica

See all True Botanica products
Name
True Botanica
Pharmacist Counseling Corner

Birch Complex Cold Extraction by True Botanica: Common Questions

Does Birch Complex Cold Extraction by True Botanica interact with any medications?
Yes. Based on its ingredients, Birch Complex Cold Extraction has a known interaction with 75 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Birch Complex Cold Extraction contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against birch during pregnancy and while breastfeeding because there isn't enough research to establish that it's safe. Talk with your pharmacist or doctor about whether this product is right for you in these situations.
Will this help with my joint pain or hair loss?
The evidence for birch on joint pain, hair loss (alopecia), and dandruff is insufficient — we don't have enough solid research to say whether it works for these uses.
What should I watch out for if I use this product?
If you have a birch pollen allergy, you're at risk for allergic reactions to this product. Topical birch products have caused allergic contact dermatitis in some people, so be alert to any rash or skin irritation. If you take diuretic drugs (water pills), check your medications below before starting.
What are the inactive ingredients in this liquid?
The liquid carrier and preservatives are water, glycerin, apple cider vinegar, salts, trace minerals, potassium sorbate, and citric acid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Birch Complex Cold Extraction is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Birch Complex Cold Extraction label
Go deeper

The Full Monographs Behind Birch Complex Cold Extraction’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Birch

Interacts with 75 drugs

Birch is a tree whose leaves, bark, and sap are used in traditional remedies, most often as a mild diuretic or for joint and urinary complaints. Solid human evidence is limited, and birch is...

Read the full Birch monograph →
Sources

Sources & How We Checked

Birch Complex Cold Extraction's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Birch 4 references
  1. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  2. Lahti, A. and Hannuksela, M. Immediate contact allergy to birch leaves and sap. Contact Dermatitis 1980;6(7):464-465. PubMed
  3. Allam JP, Wuestenberg E, Wolf H, et al. Immunologic response and safety in birch pollen sublingual versus oral vestibule immunotherapy: a pilot study. J Allergy Clin Immunol. 2014;133(6):1757-9.e3. PubMed
  4. Meyer-Hoffert U, Brasch J. Allergic contact dermatitis caused by betulin-containing triterpene extract from the outer bark of birch (Betula alba). Contact Dermatitis. 2013;68(6):382-3.

See these in context on the Birch monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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