Blood Orange Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Blood Orange Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Blood Orange Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for vitamin c source, digestive upset, stress and relaxation (aromatherapy).Based on those ingredients, 246 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Blood Orange Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Blood Orange Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Blood Orange Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Blood Orange Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: blood orange fruit extract. The extract is derived from blood orange fruit and comes in powder form with no other inactive ingredients listed.
Does it work?
Couldn't assess
The evidence we hold does not support any of the six conditions listed—pre-procedural anxiety, asthma, prostate cancer, common cold, constipation, or depression. Each has insufficient reliable evidence to rate, meaning the science to back up a benefit isn't established in our data.
How safe is it?
Well-documented data
Sweet orange fruit and juice are safe as everyday food for most people, but this is a concentrated extract, and concentrated supplements and essential oils haven't been well studied. The caution here is that you're taking a more potent form than you'd get from eating the fruit.
There have been reports of intestinal cramping (colic) in children who ate large amounts of sweet orange peel. During pregnancy and lactation, the ingredient is rated likely safe, so the data suggests it's probably okay, but talk with your doctor or pharmacist about your individual situation before taking it.
Meds to double-check
Major interaction found
Check your medications before taking this product if you take OATP substrates, pravastatin, ivermectin, celiprolol, or fexofenadine (all Major)—or P-glycoprotein substrates, quinolone antibiotics (Moderate). The extract can lower some drug levels sharply and raise others, so your doctor or pharmacist needs to weigh the risk for your specific regimen.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may appeal to someone looking for an orange extract supplement, but the interaction profile is substantial—especially if you take cholesterol, heart, allergy, antibiotic, or antiparasitic medications. The science on what it actually does for health isn't strong.
Talk with your doctor or pharmacist before starting it, and run your exact medication list through the interaction checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Blood Orange Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X001OM7WVT |
| Net contents | 100 Gram(s); 3.5 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2024 |
| DSLD ID | 311169 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Blood Orange Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Blood Orange Fruit Extract | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Color may vary
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) up to three times daily, or as directed by a physician.
General Statements
Use an accurate milligram scale to measure.
New
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Blood Orange Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Blood Orange Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container200 Amounts shown are per serving.
Blood Orange Fruit Extract
Interacts with246 drugs
Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...
Blood Orange Fruit Extract monograph & interactionsBlood Orange Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Blood Orange Extract by BulkSupplements.com interacts with a significant number of medications because its active ingredient, blood orange fruit extract, affects how your body absorbs several drug types.
The most serious interactions are with OATP substrates (a group of medications whose absorption can be reduced), pravastatin (a cholesterol drug whose levels can jump by about 149%), ivermectin (an antiparasitic whose absorption drops), celiprolol (a heart medication whose levels can fall by up to 90%), and fexofenadine (an allergy medication whose absorption can plummet by about 72%). All of these carry a Major severity rating.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions also occur with P-glycoprotein substrates (drugs whose blood levels may shift), quinolone antibiotics (calcium in fortified juices can bind to them and reduce absorption), and fexofenadine (covered above). The blood orange extract can interfere with how these medications work, sometimes by blocking their absorption and sometimes by increasing it.
Altogether, these interactions span 246 individual medications. Before you start this supplement, check your exact prescriptions with the tool on this page—and talk it over with your doctor or pharmacist, especially if you take any heart, cholesterol, antibiotic, or allergy medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Blood Orange Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Blood Orange Extract interact with 246 drugs. Click any drug to see the details.
1 of the 1 ingredient in Blood Orange Extract interact with drugs. Each result below shows which ingredient is responsible. Blood Orange Fruit Extract
AcalabrutinibCalquence
How Acalabrutinib interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Acalabrutinib interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Afatinib Dimaleate interactionAlvimopanEntereg
How Alvimopan interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Betamethasone Valerate interactionBetrixabanBevyxxa
How Betrixaban interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Betrixaban interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBoceprevirVictrelis
How Boceprevir interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Boceprevir interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Chlortetracycline interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Cimetidine interactionCisapridePropulsid
How Cisapride interacts with Blood Orange Extract — through 1 ingredient. Tap an ingredient for the detail:
Blood Orange Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Blood Orange Fruit Extract + Cisapride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Blood Orange Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Blood Orange Fruit Extract
Celiprolol (Celicard)
Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
Ivermectin (Stromectol, Others)
Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.
Pravastatin (Pravachol)
Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.
Fexofenadine (Allegra)
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
P-Glycoprotein Substrates
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.
Quinolone Antibiotics
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.
Brand information
Manufacturer and brand details for Blood Orange Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Blood Orange Extract by BulkSupplements.com: Common Questions
Does Blood Orange Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take blood orange extract while pregnant?
Does blood orange extract actually treat a cold or boost my immune system?
Are there any side effects I should watch for?
What exactly is blood orange fruit extract?
Can I take this with my cholesterol or allergy medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Blood Orange Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Blood Orange Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Blood Orange Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 17 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sweet Orange 17 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
- Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
- Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
- Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
- Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
- Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
- Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
- Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
- Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
- Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
- Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
- Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
- Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
- Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
- Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC