Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Blue Renew Methylene Blue Capsules Ingredients & Drug Interactions

by Nutricel Supplements

Blue Renew Methylene Blue Capsules label
See full label image
Capsule Category: Dietary Supplement
Most serious interaction: Major
Clinical methodology reviewed by · Updated Jul 16, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking Blue Renew Methylene Blue Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Blue Renew Methylene Blue Capsules is a dietary supplement by Nutricel Supplements with 5 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 605 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Methylene Blue, N-Acetyl-Cysteine, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blue Renew Methylene Blue Capsules by Nutricel Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Blue Renew Methylene Blue Capsules by Nutricel Supplements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Blue Renew Methylene Blue Capsules by Nutricel Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Blue Renew contains 5 active ingredients. Glycine is an amino acid sometimes studied for schizophrenia and other conditions.

Creatine monohydrate is a compound that supports muscle energy and strength. N-Acetyl-Cysteine (NAC) is a modified amino acid with antioxidant properties and is clinically proven for acetaminophen overdose.

Hydrolyzed collagen is a broken-down form of collagen protein used in some skin and joint supplements. Methylene blue is a synthetic compound with a long history in medical use, though its role in supplements for cognitive function and other claims remains unproven.

The product also contains inactive ingredients — gelatin, silicon dioxide, and cellulose — which serve as the capsule material and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cellular energy mental clarity and antioxidant support.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Cognitive impairment, Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness — and 4 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Aging skin.
  • Also on file: Creatine is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Aging skin, Cognitive function.

Evidence for most of these ingredients is limited or absent for the purposes typically marketed in supplements. Glycine is possibly effective for schizophrenia.

Creatine is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), and for certain rare genetic creatine-deficiency disorders; it appears ineffective for Huntington disease and osteopenia. Hydrolyzed collagen is possibly effective for aging and dry skin, but appears ineffective for muscle strength.

N-Acetyl-Cysteine is effective for acetaminophen poisoning and possibly effective for bronchitis; effectiveness for other uses in supplements has not been established in our data. Methylene blue's effectiveness for cognitive function, age-related cognitive decline, bipolar disorder, schizophrenia, chronic fatigue, or cancer is not established — the evidence we hold is insufficient to rate any of these claims.

The evidence, ingredient by ingredient Glycine Creatine N-acetyl Cysteine (nac) Collagen Peptides Methylene Blue

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine is generally well tolerated in healthy adults but requires caution in people with kidney problems. Glycine is generally well tolerated at typical doses, though long-term safety data are limited; rare side effects include mild sedation, soft stools, nausea, vomiting, and dry mouth, which resolve quickly if you stop taking it.

N-Acetyl-Cysteine is generally well tolerated at normal doses; common mild side effects are diarrhea, dry mouth, heartburn, nausea, and vomiting. Hydrolyzed collagen is generally well tolerated with rare side effects such as nausea and diarrhea.

Methylene blue in prescription form is generally well tolerated when used as directed, though oral side effects can include blue or green urine, diarrhea, headache, nausea, and vomiting; safety in supplement form is less clear. Regarding pregnancy: creatine and methylene blue should be avoided — safety has not been established or is likely unsafe.

N-Acetyl-Cysteine is possibly safe in pregnancy but has not been well studied; talk with your doctor. Glycine and hydrolyzed collagen lack sufficient pregnancy safety data; discuss with your doctor.

For breastfeeding, creatine and methylene blue should be avoided due to insufficient safety data. Glycine, N-Acetyl-Cysteine, and hydrolyzed collagen also lack enough safety information during nursing; caution is advised and your healthcare provider should weigh the decision.

Side effects, ingredient by ingredient Glycine Creatine N-acetyl Cysteine (nac) Collagen Peptides Methylene Blue

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — N-acetyl Cysteine (nac), Glycine, Methylene Blue.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 605 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take nitroglycerin, blood pressure medications, blood thinners or antiplatelet drugs, clozapine (an antipsychotic), serotonergic drugs (certain antidepressants and related medications), anticholinergic drugs, chloroquine, or activated charcoal, check with your doctor or pharmacist before taking this product. The interactions range from Major to Moderate severity and may reduce a drug's effectiveness or increase side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with very different evidence profiles and some serious medication interactions. It may interest people curious about creatine's proven effects on muscle strength, though the other ingredients' supplement roles are not well established.

Anyone taking nitroglycerin, blood pressure drugs, blood thinners, antipsychotics, antidepressants, or antimalarials should absolutely check their exact medications with your doctor or pharmacist before starting. Pregnant or breastfeeding individuals should talk with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 16, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blue Renew Methylene Blue Capsules, straight from the product label.

Brand Nutricel Supplements
Barcode (UPC) 199284279568
Net contents 60 Capsules
Market status On market
Added to our catalog Jul 16, 2026
Product type Dietary Supplement
Supplement form Capsule
Dietary claims / uses Anti-aging support, Cellular energy, Mental clarity, Enhanced antioxidant activity, Overall wellness, Cognitive and nutritional support
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blue Renew Methylene Blue Capsules by Nutricel Supplements, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
1 Capsule
Maximum serving Sizes:
1 Capsule
Servings per container
60
UPC/BARCODE
199284279568
IngredientAmount% DV
Glycine86 mg--
Creatine Monohydrate86 mg--
N-Acetyl-Cysteine86 mg--
Hydrolyzed Collagen258 mg--
Methylene Blue7 mg--

Other ingredients: Gelatin, Silicone Dioxide, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

1 Capsule Per Day

Warnings

Methylene Blue may cause blue-tinted urine, which is normal and harmless. Do not use if pregnant, nursing, have G6PD deficiency, or are taking serotonin-affecting medications (including SSRIs). Always consult your healthcare provider before use, as certain medications may interact with Methylene Blue.

Do not take Methylene Blue if you: take serotonin-raising medications; are pregnant or nursing; have a G6PD (glucose-6-phosphate dehydrogenase) deficiency. Known side effect: blue urine. May experience mild, temporary effects when starting methylene blue; symptoms may include headaches, fatigue, stomachaches, and rash.

Marketing

Advanced Anti-Aging Formula

Designed for Cellular Health. May Support Energy Levels.*

Energy & Anti-Aging Support — Blue Renew Can Help Promote: Cellular Energy*, Mental Clarity*, Enhanced Antioxidant Activity*, Overall Wellness*

Designed for individuals incorporating methylene blue into a daily cognitive and nutritional support routine

Other

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blue Renew Methylene Blue Capsules by Nutricel Supplements label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

Blue Renew Methylene Blue Capsules label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in Blue Renew Methylene Blue Capsules by Nutricel Supplements

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
86 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Creatine Monohydrate

No known
interactions
86 mg per serving Form: Monohydrate

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

N-Acetyl-Cysteine

Interacts with
294 drugs
86 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-Cysteine monograph & interactions

Hydrolyzed Collagen

No known
interactions
258 mg per serving Form: Hydrolyzed, Bovine, Type I and III

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Hydrolyzed Collagen monograph & interactions

Methylene Blue

Interacts with
315 drugs
7 mg per serving Form: USP/Pharma Grade

Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it is also use...

Methylene Blue monograph & interactions

Other (inactive) ingredients: Gelatin, Silicone Dioxide, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blue Renew Methylene Blue Capsules by Nutricel Supplements Drug Interactions

Want to check YOUR meds against Blue Renew Methylene Blue Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
605Drugs
1 Major 604 Moderate

Ingredients driving the most interactions

Methylene Blue 315
N-Acetyl-Cysteine 294
Glycine 1

Individual Drug Interactions

The ingredients in Blue Renew Methylene Blue Capsules interact with 605 drugs. Click any drug to see the details.

3 of the 5 ingredients in Blue Renew Methylene Blue Capsules interact with drugs. Each result below shows which ingredient is responsible. Methylene Blue N-Acetyl-Cysteine Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Blue Renew Methylene Blue Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Methylene Blue2 drug types · 315 drugs

Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects. In a case report, a critically-ill male in his mid-60s developed a toxicological process attributed to anticholinergic syndrome following treatment with methylene blue for vasoplegia. Symptoms included anhidrosis, fever, lactic acidosis, mucosal dryness, and pupil dilation. Potential exacerbating factors included renal failure and use of fentanyl intra-operatively.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome. Methylene blue inhibits monoamine oxidase A. Intravenous or intrapulmonary use has resulted in serotonin syndrome, including reported fatalities, in patients taking some serotonergic drugs. This effect has not been reported with oral methylene blue. However, tell patients to avoid taking methylene blue with serotonergic drugs.

Likelihood Possible Evidence C
Methylene Blue full monograph & interactions

N-Acetyl-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-Cysteine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blue Renew Methylene Blue Capsules, from the product label.

Nutricel Supplements

See all Nutricel Supplements products
Pharmacist Counseling Corner

Blue Renew Methylene Blue Capsules by Nutricel Supplements: Common Questions

Does Blue Renew Methylene Blue Capsules by Nutricel Supplements interact with any medications?
Yes. Based on its ingredients, Blue Renew Methylene Blue Capsules has a known interaction with 605 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blue Renew Methylene Blue Capsules contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is methylene blue in this supplement the same as prescription methylene blue?
Methylene blue is the same compound in both forms, but how it behaves in a supplement versus a prescription medication is unclear. Prescription forms are carefully dosed and monitored by a doctor; supplement products are not. How supplement-grade methylene blue affects your body may differ from what we know about the prescription version.
Will creatine make me bulk up?
Creatine is possibly effective for muscle strength and athletic performance, and the evidence comes mostly from people doing resistance training. It may help your muscles work harder and recover, but it is not a magic ingredient — you still need exercise and proper nutrition. It can also cause water retention and dehydration if you do not drink enough water.
Can I take this if I have kidney problems?
Creatine, one of the ingredients here, requires caution if you have kidney issues because your kidneys process it. Talk with your doctor or pharmacist before taking this product if you have any kidney condition or reduced kidney function.
What does N-Acetyl-Cysteine do?
NAC is proven effective for acetaminophen (Tylenol) poisoning and is possibly effective for bronchitis. It is an antioxidant and may support lung and respiratory health, but most other uses marketed for NAC in supplements are not well established in the evidence we hold.
Is my urine turning blue or green normal?
Yes. Methylene blue is excreted in your urine and can turn it blue or green. This is harmless and will stop once you discontinue the supplement. If you notice this color change and did not expect it, it confirms the methylene blue is being absorbed.
Can I take this while pregnant?
No. Creatine and methylene blue should be avoided in pregnancy because safety has not been established or the data advise against it. NAC has insufficient study in pregnancy, and glycine and collagen lack adequate pregnancy safety data. Talk with your doctor before taking any supplement while pregnant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blue Renew Methylene Blue Capsules is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blue Renew Methylene Blue Capsules label
Go deeper

The Full Monographs Behind Blue Renew Methylene Blue Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph → Herb & supplement monograph

Methylene Blue

Interacts with 315 drugs

Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it is also used as a diagnostic dye. Its popular use a...

Read the full Methylene Blue monograph →
Sources

Sources & How We Checked

Blue Renew Methylene Blue Capsules's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 239 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
  19. Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
  20. Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
  21. Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
  22. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. PubMed
  23. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. PubMed
  24. Kreider, R. B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med 1999;27(2):97-110. PubMed
  25. Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am.Diet.Assoc 1999;99(5):593-595.
  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
  27. Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
  28. Tarnopolsky, M. A. Potential benefits of creatine monohydrate supplementation in the elderly. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. PubMed
  29. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
  30. Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism 2001;50(12):1429-1434. PubMed
  31. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Med Sci.Sports Exerc. 2001;33(12):2111-2117. PubMed
  32. Cox, G., Mujika, I., Tumilty, D., and Burke, L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr.Exerc.Metab 2002;12(1):33-46. PubMed
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See these in context on the Creatine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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