Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Blueberry Leaf Extract Ingredients & Drug Interactions

by Solgar

Blueberry Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blueberry Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blueberry Leaf Extract is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, heart health, brain and memory health.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are standardized Blueberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blueberry Leaf Extract by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Blueberry Leaf Extract by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blueberry Leaf Extract by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This Solgar product contains 2 active ingredients: a standardized blueberry extract and raw blueberry powder. Both deliver the compounds that give blueberries their reputation as an antioxidant-rich food, now in concentrated form.

The rest is inactive ingredients — cellulose, silica, and magnesium stearate — the usual capsule filler and binder material.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Blueberry product and its label doesn't state a use — see Blueberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on blueberry extract for most uses doesn't reach a clear threshold yet. For hypertension, the data suggests it's possibly ineffective.

For age-related cognitive decline, anxiety, athletic performance, high cholesterol, and heart disease, there simply isn't enough reliable evidence to rate whether it works. If you're hoping this supplement will treat or prevent any specific condition, talk it over with your doctor — the data we hold doesn't yet support those claims.

The evidence, ingredient by ingredient Blueberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blueberries as a food are generally well tolerated. In supplement form, freeze-dried blueberries can cause constipation, diarrhea, nausea, or vomiting in some people — one clinical trial found that about a quarter of participants taking a high dose dropped out in the first week due to stomach upset.

For pregnancy and breastfeeding, the safety data rates blueberry as likely safe, but the safety notes flag that concentrated supplements haven't been well studied in pregnancy, and the safety of high-dose extracts during breastfeeding is unknown. If you're pregnant or nursing, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Blueberry

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blueberry.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, flurbiprofen (Ansaid), or buspirone (BuSpar), talk with your doctor or pharmacist before using this product. All three are Minor-severity interactions, but they're worth confirming with your own healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Blueberry Leaf Extract is generally well tolerated as a supplement, but it does interact with diabetes medications, flurbiprofen, and buspirone. If you take any of those or have diabetes, check with your own doctor or pharmacist before starting it.

Otherwise, if you're looking for it to treat a specific health condition, know that the evidence isn't established yet for most uses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blueberry Leaf Extract, straight from the product label.

Brand Solgar
Barcode (UPC) 033984041127
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216669
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blueberry Leaf Extract by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
033984041127
IngredientAmount% DV
standardized Blueberry extract100 mg--
raw Blueberry powder100 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, PhytO2X Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Standardized Full Potency (SFP) Herbs are developed through a unique process that integrates the ideologies of both traditional herbalism and standardized herbal technology. To ensure consistent and reliable phytonutrient levels, we isolate a controlled amount of these important active plant compounds. Then we blend these enhanced, "standardized" compounds with all of the components that occur naturally in the whole raw herb. The result is a potent, premium-quality standardized herbal extract with all of the synergistic and beneficial qualities found in nature.

Solgar's Blueberry Leaf Extract Vegetable Capsules are free of sugar, salt, corn, yeast, wheat and dairy products and are formulated without the use of artificial preservatives, flavors or colors.

Standardized Full potency

Suitable for vegetarians

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Contains soy.

Brand IP Statement(s)

PHYTO2X SYSTEM

General Statements

Solgar since 1947

Formula

(Vaccinium angustifolium)

Phyto2X is a special blend of antioxidants, the purpose of which is to maintain the freshness of the ingredients.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As an herbal dietary supplement for adults, take one (1) vegetable capsule up to two (2) times daily, preferably at mealtime, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blueberry Leaf Extract by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blueberry Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blueberry Leaf Extract by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Standardized Blueberry extract

Interacts with
88 drugs
100 mg per serving Form: Chlorogenic Acid

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...

Standardized Blueberry extract monograph & interactions

Raw Blueberry powder

Interacts with
88 drugs
100 mg per serving

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...

Raw Blueberry powder monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, PhytO2X Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blueberry Leaf Extract by Solgar Drug Interactions

Want to check YOUR meds against Blueberry Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
88Drugs
88 Minor

Ingredients driving the most interactions

standardized Blueberry extract 88

Individual Drug Interactions

The ingredients in Blueberry Leaf Extract interact with 88 drugs. Click any drug to see the details.

1 of the 2 ingredients in Blueberry Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. standardized Blueberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Blueberry Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

standardized Blueberry extract3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D
Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B
Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B
standardized Blueberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blueberry Leaf Extract, from the product label.

Solgar

See all Solgar products
Name
Solgar Vitamin and Herb
City
Leonia
State
N.J.
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Blueberry Leaf Extract by Solgar: Common Questions

Does Blueberry Leaf Extract by Solgar interact with any medications?
Yes. Based on its ingredients, Blueberry Leaf Extract has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blueberry Leaf Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on diabetes medication?
Maybe, but check first. Blueberry extract can theoretically lower blood sugar, so taking it with diabetes drugs could raise your risk of low blood sugar. Your doctor or pharmacist will tell you if it's safe for you or if you need to adjust your medication or monitor your levels more closely.
Does this actually help with brain health or memory?
The evidence we have doesn't establish that yet. For age-related cognitive decline, there isn't enough reliable evidence to say whether it works. If you're hoping to use it for that reason, talk it over with your doctor.
Is it safe to take if I'm pregnant or breastfeeding?
The rating is listed as likely safe, but concentrated supplements haven't been well studied in pregnancy, and the safety of high-dose extracts during breastfeeding is unknown. Talk with your doctor or pharmacist for advice tailored to your situation.
What are the side effects?
Blueberry extract is generally well tolerated. Some people taking freeze-dried blueberries have reported constipation, diarrhea, nausea, or vomiting — one study found about a quarter of participants dropped out in the first week due to stomach upset. Start low and see how you feel.
Does this have any fillers?
Yes. Along with the active blueberry ingredients, the capsule contains microcrystalline cellulose, vegetable cellulose, silica, vegetable magnesium stearate, and a PhytO2X blend — standard binder and filler materials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blueberry Leaf Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blueberry Leaf Extract label
Go deeper

The Full Monographs Behind Blueberry Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph →
Sources

Sources & How We Checked

Blueberry Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blueberry 7 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
  3. Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
  4. Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
  5. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
  6. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
  7. Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

See these in context on the Blueberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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