Bo He Alcohol Free Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Bo He Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bo He Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 798 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bo He herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bo He Alcohol Free by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Bo He Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bo He Alcohol Free by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient, a Bo He herb extract, which our data links to our peppermint monograph. It is listed as a dry extract in a liquid form.
The other ingredients are inactive: glycerin and water. These are listed as inactive ingredients only and are not counted as actives.
Does it work?
Strong evidence
Our data rates the peppermint-linked ingredient as Likely Effective for irritable bowel syndrome (IBS). It is rated Possibly Effective for dyspepsia, nausea and vomiting caused by chemotherapy, colon spasm related to barium enema, and adverse effects associated with endoscopy.
These ratings come from the peppermint data we hold, so they describe the peppermint-linked ingredient, not a guaranteed result from this specific product.
How safe is it?
Well-documented data
Our safety notes say peppermint tea and culinary use are generally well tolerated, while concentrated oil should be used carefully. Our adverse effect data for oral peppermint oil lists abdominal pain, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting as the most common effects.
A single case of a serious allergic reaction to peppermint candy has been reported, and large amounts may cause burns. For pregnancy and breastfeeding, our data rates this ingredient as Likely Safe.
Talk with your own doctor or pharmacist about whether it fits your situation.
Meds to double-check
Moderate interaction found
Double-check medications that are cleared by CYP3A4, CYP2C19, or CYP2C9 enzymes, and any cyclosporine, before taking this product. Each of these is rated Moderate in our data.
Drugs cleared by CYP1A2 enzymes carry a Minor rating. Confirm your exact medications with your own doctor or pharmacist, or use the search tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may suit adults looking for a peppermint-based liquid for the purposes our ratings cover, such as IBS. If you take any prescription medication, especially drugs cleared by CYP3A4 enzymes or cyclosporine, be careful and check the interaction details first.
Talk it over with your own doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bo He Alcohol Free, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 6175033371770 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 323991 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bo He Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bo He herb Extract, Dry | 1156 mg | -- |
Other ingredients: Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Mentha haplocalyx
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
General Statements
Organic raw material.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bo He Alcohol Free by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bo He Alcohol Free by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Bo He herb Extract, Dry
Interacts with798 drugs
Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...
Bo He herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Bo He Alcohol Free by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Herbal Terra's Bo He Alcohol Free interacts with medications through its Bo He herb extract, which our data links to peppermint.
The most serious interactions we list are rated Moderate. The worst of these is for drugs cleared by CYP3A4 enzymes (liver enzymes that break down many medications).
Theoretically, the extract could increase levels of these drugs.
Read the full breakdown — every affected drug type, severity by severity
The same Moderate rating applies to drugs cleared by CYP2C19 and CYP2C9 enzymes, and to cyclosporine, where the extract might raise levels and adverse effects. The CYP2C19 and CYP2C9 findings come from lab research and have not been reported in humans.
The cyclosporine finding comes from animal research. For drugs cleared by CYP1A2 enzymes, the severity is Minor, and clinical research on peppermint tea did not significantly change caffeine metabolism.
We hold data for this one active ingredient, and it does have documented interactions, so no ingredient is interaction-free in our data. Because the list is long and some effects are theoretical, check your exact medications with the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bo He Alcohol Free?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bo He Alcohol Free interact with 798 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bo He Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Bo He herb Extract, Dry
CapivasertibTruqap
How Capivasertib interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Capivasertib interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Carbamazepine interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionCarbetapentane, Chlorpheniramine, PhenylephrineRicotuss
How Carbetapentane, Chlorpheniramine, Phenylephrine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Carbetapentane, Chlorpheniramine, Phenylephrine interactionCarbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium GuaiacolsulfonateCophene-X
How Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Cariprazine Hydrochloride interactionCarisoprodolRela, Soma
How Carisoprodol interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
Read the full Bo He Herb Extract, Dry + Carisoprodol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Bo He Herb Extract, Dry + Carvedilol interactionCelecoxibCelebrex, Elyxyb
How Celecoxib interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Bo He Herb Extract, Dry + Celecoxib interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Bo He Herb Extract, Dry + Celecoxib, Tramadol interactionCevimelineEvoxac
How Cevimeline interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Cevimeline interactionChlorpheniramineChlor-Trimeton, Teldrin
How Chlorpheniramine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine interactionChlorpheniramine Maleate, Dextromethorphan HydrobromideCoricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief
How Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine Polistirex, Codeine Polistirex interactionChlorpheniramine Tannate, Phenylephrine TannateRicobid
How Chlorpheniramine Tannate, Phenylephrine Tannate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine Tannate, Phenylephrine Tannate interactionChlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine TannateHistatan, R Tannamine, R-Tannate, Rhinatate, Tri Tannate, Triotann +1 more
How Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate interactionChlorpheniramine, Hydrocodone, PseudoephedrineTussend
How Chlorpheniramine, Hydrocodone, Pseudoephedrine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Hydrocodone, Pseudoephedrine interactionChlorpheniramine, MethscopolamineAllerx
How Chlorpheniramine, Methscopolamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Methscopolamine interactionChlorpheniramine, Methscopolamine, PhenylephrineAH Chew, DA, DA II, Dallergy, Dallergy ER, Dura Vent DA +9 more
How Chlorpheniramine, Methscopolamine, Phenylephrine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Methscopolamine, Phenylephrine interactionChlorpheniramine, Methscopolamine, PhenylpropanolaminePannaz
How Chlorpheniramine, Methscopolamine, Phenylpropanolamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Methscopolamine, Phenylpropanolamine interactionChlorpheniramine, Methscopolamine, PseudoephedrineMescolor, Rescon-Mx, Xiral
How Chlorpheniramine, Methscopolamine, Pseudoephedrine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Methscopolamine, Pseudoephedrine interactionChlorpheniramine, Phenindamine, PhenylpropanolamineNolamine
How Chlorpheniramine, Phenindamine, Phenylpropanolamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenindamine, Phenylpropanolamine interactionChlorpheniramine, PhenylephrineDallergy JR, Ed A Hist, Histatab Plus, Rynatan
How Chlorpheniramine, Phenylephrine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenylephrine interactionChlorpheniramine, Phenylephrine, PhenylpropanolamineRutuss
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionChlorpheniramine, Phenylephrine, Phenylpropanolamine, PhenyltoloxamineDe Con, Decongest, Naldecon, Nalspan SR, Tri Phen Mine Sr, Uni Decon +1 more
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interactionChlorpheniramine, Phenylephrine, Phenylpropanolamine, PyrilamineHistalet Forte, Poly Hist Forte, Vanex Forte
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interactionChlorpheniramine, Phenylephrine, PhenyltoloxamineCom Time, Comhist, Comhist LA, Linhist LA, Q Hist LA
How Chlorpheniramine, Phenylephrine, Phenyltoloxamine interacts with Bo He Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Bo He Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Bo He Herb Extract, Dry + Chlorpheniramine, Phenylephrine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bo He Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bo He herb Extract, Dry
Cyclosporine (Neoral, Sandimmune)
Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.
Brand information
Manufacturer and brand details for Bo He Alcohol Free, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Bo He Alcohol Free by Herbal Terra: Common Questions
Does Bo He Alcohol Free by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product safe to take during pregnancy or while breastfeeding?
Does this product work for irritable bowel syndrome?
What side effects are most common?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bo He Alcohol Free is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bo He Alcohol Free’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bo He Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Peppermint 41 references
- Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
- Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
- Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
- Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
- May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
- Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
- Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
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