Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Brain Energy Ingredients & Drug Interactions

by Douglas Laboratories

Brain Energy label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brain Energy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brain Energy is a dietary supplement by Douglas Laboratories with 5 active ingredients. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.Based on those ingredients, 1,345 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola rosea extract, Octacosanol, L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Brain Energy by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Brain Energy by Douglas Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Brain Energy by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Brain Energy contains five active ingredients. L-Methionine, L-Tyrosine, Octacosanol, DL-Phenylalanine, and Rhodiola rosea extract are the working components of this formula.

The product also contains inactive ingredients—hydroxypropyl methylcellulose, microcystalline cellulose, vegetable stearate, and silica—which serve as capsule material and binders but don't provide therapeutic effects.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Energy and mental performance support.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Cognitive function, Depression, Fatigue, Generalized anxiety disorder (GAD) — and 4 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Memory.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

The evidence for these ingredients is mixed and in many cases limited. L-Tyrosine appears possibly effective for cognitive function and memory, though it's ineffective for athletic performance.

For Phenylketonuria (PKU), it's rated effective. L-Methionine is possibly effective for neural tube birth defects, but evidence is insufficient to rate it for acetaminophen poisoning, hay fever, asthma, or colorectal cancer.

Octacosanol and Rhodiola rosea have insufficient evidence in our data for the conditions they're studied for—including athletic performance, Parkinson disease, hyperlipidemia, altitude sickness, anxiety, and arrhythmia. The overall evidence to support Brain Energy for cognitive or energy benefits is not established in our data.

The evidence, ingredient by ingredient Methionine Tyrosine Octacosanol Rhodiola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Methionine is generally well tolerated when consumed in food amounts, but high-dose supplements may cause side effects like dizziness, drowsiness, headache, and vomiting; it's rated likely safe during pregnancy and lactation. L-Tyrosine is generally well tolerated in healthy adults but not well studied in pregnancy or while breastfeeding; common side effects at higher doses include headache, fatigue, nausea, and heartburn.

Octacosanol is generally well tolerated for the studied durations, but long-term safety is limited, and it's best avoided in pregnancy and while breastfeeding. Rhodiola is generally well tolerated for short-term use, though long-term safety hasn't been well studied; it should be avoided in pregnancy and while breastfeeding.

Common side effects of rhodiola include dizziness and changes in saliva production (dry mouth or excessive saliva). We hold no pregnancy/lactation data for DL-Phenylalanine.

Side effects, ingredient by ingredient Methionine Tyrosine Octacosanol Rhodiola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Octacosanol, Rhodiola, Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,346 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antihypertensive drugs, antidiabetes drugs, levodopa or levodopa/carbidopa, thyroid hormones, blood thinners or antiplatelet drugs, beta-blockers, or medications metabolized by your liver (especially CYP2C9 substrates, losartan, P-glycoprotein substrates, or immunosuppressants), check your exact medications with the tool below before using this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Brain Energy might interest you if you're exploring cognitive support, though evidence for its ingredients isn't robust. If you take any blood pressure medications, diabetes drugs, thyroid hormones, Parkinson medications, blood thinners, or drugs metabolized by your liver, you should talk to your pharmacist before starting this product.

Pregnancy and breastfeeding: several ingredients lack safety data—check with your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brain Energy, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539019559
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231987
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brain Energy by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
310539019559
IngredientAmount% DV
L-Methionine60 mg--
L-Tyrosine200 mg--
Octacosanol2 mg--
DL-Phenylalanine300 mg--
Rhodiola rosea extract75 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcystalline Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 capsule in the morning and 1 capsule with lunch, or as directed by your health professional.

Precautions

Warning:If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Phenylketonurics: Contains Phenylalanine.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Dopamine support

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brain Energy by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brain Energy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brain Energy by Douglas Laboratories

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Methionine

No known
interactions
60 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

L-Methionine monograph & interactions

L-Tyrosine

Interacts with
21 drugs
200 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Octacosanol

Interacts with
248 drugs
2 mg per serving

Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid huma...

Octacosanol monograph & interactions

DL-Phenylalanine

300 mg per serving

Rhodiola rosea extract

Interacts with
1,271 drugs
75 mg per serving Form: Rosavins, Salidrosides

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcystalline Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brain Energy by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Brain Energy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,345Drugs
734 Moderate 611 Minor

Ingredients driving the most interactions

Rhodiola rosea extract 1,271
Octacosanol 248
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Brain Energy interact with 1,345 drugs. Click any drug to see the details.

3 of the 5 ingredients in Brain Energy interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea extract Octacosanol L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Brain Energy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea extract full monograph & interactions

Octacosanol7 drug types · 248 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Octacosanol is the main component of policosanol. Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to initiating warfarin does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Octacosanol is the main component of policosanol. In humans, policosanol can decrease blood glucose. It is not clear if these effects occur with the use of octacosanol.

Likelihood Possible Evidence B
Beta-Blockers

Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.
Octacosanol is the main component of policosanol. Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the hypotensive effects of propranolol. It is not clear if these effects occur with the use of octacosanol.

Likelihood Probable Evidence A
Levodopa/Carbidopa (Sinemet)

Concomitant use may worsen symptoms of Parkinson disease.
One small clinical study suggests that octacosanol might worsen dyskinesias and increase nervous tension in some patients being treated with levodopa/carbidopa.

Likelihood Probable Evidence D
Nitroprusside (Nitropress)

Theoretically, octacosanol might enhance the hypotensive effects of nitroprusside.
Octacosanol is the main component of policosanol. Animal research shows that taking policosanol along with nitroprusside can increase the hypotensive effects of nitroprusside. It is not clear if these effects occur with the use of octacosanol.

Likelihood Possible Evidence D
Propranolol (Inderal)

Theoretically, octacosanol might enhance the hypotensive effects of propranolol.
Octacosanol is the main component of policosanol. Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol. It is not clear if these effects occur with the use of octacosanol.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Octacosanol is the main component of policosanol. Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Therefore, there is concern that taking policosanol with warfarin might increase the risk of bruising and bleeding. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. It is not clear if these effects occur with the use of octacosanol.

Likelihood Possible Evidence B
Octacosanol full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brain Energy, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Brain Energy by Douglas Laboratories: Common Questions

Does Brain Energy by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Brain Energy has a known interaction with 1,345 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brain Energy contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-Tyrosine do in this formula?
L-Tyrosine is possibly effective for cognitive function and memory and is effective for a condition called phenylketonuria (PKU). In this product, it's likely intended to support thinking and mental clarity, though the overall evidence for the formula as a whole isn't well established.
Is this safe to take during pregnancy?
No, not without talking to your doctor first. L-Methionine is rated likely safe, but Octacosanol and Rhodiola rosea should both be avoided during pregnancy due to insufficient safety data. We also lack pregnancy data for DL-Phenylalanine. Talk to your pharmacist or doctor before using this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
It's not recommended without guidance from your doctor or pharmacist. Octacosanol and Rhodiola rosea should be avoided while breastfeeding due to insufficient safety data, and we lack breastfeeding information for DL-Phenylalanine. L-Methionine and L-Tyrosine also haven't been well studied in breastfeeding.
What are the most common side effects?
L-Tyrosine may cause headache, fatigue, nausea, or heartburn. Rhodiola commonly causes dizziness and changes in saliva production (dry mouth or increased saliva). L-Methionine can cause dizziness, drowsiness, headache, and irritability at higher doses.
Does this product contain fillers?
Yes. The capsule contains inactive ingredients including hydroxypropyl methylcellulose, microcystalline cellulose, vegetable stearate, and silica, which serve as binders and capsule material.
Will this help my memory?
L-Tyrosine is rated possibly effective for memory, but the overall evidence supporting this product for memory or brain energy isn't well established in our data. Talk to your pharmacist about whether this is a good fit for your specific needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brain Energy label
Go deeper

The Full Monographs Behind Brain Energy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Octacosanol

Interacts with 248 drugs

Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid human evidence is limited and results are mi...

Read the full Octacosanol monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph →
Sources

Sources & How We Checked

Brain Energy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Octacosanol 16 references
  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. PubMed
  5. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  6. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  7. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  8. Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
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  10. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
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  12. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
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  15. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
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See these in context on the Octacosanol monograph →

Rhodiola 13 references
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  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
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See these in context on the Rhodiola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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