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Dietary supplement

Brain Health Support Ingredients & Drug Interactions

by Amandean

Brain Health Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brain Health Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Brain Health Support is a dietary supplement by Amandean with 3 active ingredients. Its ingredients are commonly taken for preventing or treating magnesium deficiency, constipation, muscle cramps.Based on those ingredients, 508 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lion's Mane extract, Magnesium, Alpha-Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brain Health Support by Amandean

Ask about any prescription or over-the-counter medication and we check it for interactions with Brain Health Support by Amandean — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Brain Health Support by Amandean

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Magnesium” is listed as a grouped ingredient — the label gives one combined amount (72 mg) without saying how much of each component you get.
  • “Alpha-Glycerylphosphorylcholine” is listed as a grouped ingredient — the label gives one combined amount (150 mg) without saying how much of each component you get.

Brain Health Support contains three active ingredients. Magnesium (as Magtein) is a mineral that supports numerous body functions and has established roles in constipation relief and heartburn.

Alpha-Glycerylphosphorylcholine and AlphaSize (alpha-GPC) is a compound naturally found in the brain, studied for its potential role in memory and cognitive decline. Lion's mane mushroom extract is derived from a medicinal fungus used in traditional medicine for brain health.

The capsules also contain inactive ingredients — rice extract blend and hydroxypropyl methylcellulose — that serve as fillers and the capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cognitive function and memory support.
  • We looked for evidence on: Cognitive function, Memory, Cognitive impairment, Alzheimer disease, Dementia, Anxiety — and 3 related terms.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Magnesium is rated "Insufficient Reliable Evidence To Rate" for Perioperative anxiety, Cognitive impairment.
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for this product's ingredients is mixed. Alpha-GPC is possibly effective for Alzheimer disease, but the evidence isn't established for brain tumor, general cognitive function, vascular dementia, or stroke.

Magnesium is effective for constipation, heartburn, magnesium deficiency, and pre-eclampsia in pregnancy — but those aren't the claims made here. Lion's mane mushroom hasn't been rated as effective for Alzheimer disease, anxiety, athletic performance, cancer, or general cognitive function; the evidence simply isn't there yet.

If you're considering this product for cognitive support or memory, the data we have doesn't show it works for those purposes in most of the ingredients.

The evidence, ingredient by ingredient Magnesium Alpha-gpc Lion's Mane Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnesium is generally well tolerated at recommended doses, though it can cause diarrhea, nausea, vomiting, and gastrointestinal irritation — which is common and usually mild. Alpha-GPC is usually well tolerated, but rarely causes dizziness, headache, insomnia, nausea, or vomiting.

One important concern: alpha-GPC taken for 2 months or longer has been rarely linked to an elevated risk of stroke compared with non-users or shorter-term use. Lion's mane mushroom is generally well tolerated when eaten as food, but long-term supplement safety hasn't been well studied.

The product's long-term safety overall is not fully established. For pregnancy, magnesium is likely safe at normal dietary amounts and possibly safe as a supplement under your doctor's guidance, but alpha-GPC and lion's mane lack enough safety data — talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Magnesium Alpha-gpc Lion's Mane Mushroom

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Magnesium, Alpha-gpc, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 508 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take levodopa/carbidopa (Parkinson's medication) — magnesium can significantly reduce its levels. Also double-check skeletal muscle relaxants, potassium-sparing diuretics, calcium channel blockers, acid reducers, sulfonylureas (diabetes drugs), quinolone antibiotics, bisphosphonates, blood thinners, antiplatelet drugs, other diabetes medications, or immunosuppressants.

Use the medication checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines three ingredients with different levels of evidence and different safety profiles. If you take levodopa/carbidopa, skeletal muscle relaxants, blood pressure medications, diabetes drugs, antibiotics, bisphosphonates, blood thinners, or immunosuppressants, you'll need to check your specific medications before using it.

Talk to your pharmacist, especially if you're pregnant, breastfeeding, or take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brain Health Support, straight from the product label.

Brand Amandean
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 335185
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brain Health Support by Amandean, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
IngredientAmount% DV
Magnesium72 mg17%
Alpha-Glycerylphosphorylcholine150 mg--
AlphaSize300 mg--
Magtein1000 mg--
Lion's Mane extract200 mg--

Other ingredients: Rice extract Blend, Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Selectively-Sourced ingredients Magtein is the only form of magnesium shown to cross the blood-brain barrier and support cognitive function. AlphaSize Alpha GPC is made from all-natural starting material in Italy. Our lion's mane is grown on certified organic maple logs, hand harvested, hot water-extracted and contains a minimum 25% of beta-glucans.

Magnesium L-Threonate Lion's Mane + Alpha GPC

Suggested/Recommended/Usage/Directions

Directions for use As a dietary supplement, take 3 capsules per day.

Precautions

Caution Use as directed. Discontinue use immediately if you experience any negative effects.

If you are pregnant or nursing, under the age of 18, or have a known medical condition, you should consult a physician prior to use.

If you are pregnant or nursing, under the age of 18, or have a known medical condition, you should consult a physician prior to use. Keep out of reach of children.

Seals/Symbols

Certified Plastic Neutral Product

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Cognition Focus Performance Sleep

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Magtein is protected under a family of US patents, pending patents, and is protected worldwide. Magtein is a trademark of and is licensed exclusively by ThreoTech LLC. AlphaSize is a Registered Trademark of Chemi Nutra, LLC in the USA and other jurisdictions.

Storage

Storage Store in a cool, dry place out of direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brain Health Support by Amandean label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brain Health Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brain Health Support by Amandean

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Magnesium

Interacts with
295 drugs
72 mg per serving

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
150 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Lion's Mane extract

Interacts with
327 drugs
200 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane extract monograph & interactions

Other (inactive) ingredients: Rice extract Blend, Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brain Health Support by Amandean Drug Interactions

Want to check YOUR meds against Brain Health Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
508Drugs
6 Major 484 Moderate 18 Minor

Ingredients driving the most interactions

Lion's Mane extract 327
Magnesium 295
Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Brain Health Support interact with 508 drugs. Click any drug to see the details.

3 of the 3 ingredients in Brain Health Support interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane extract Magnesium Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Brain Health Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane extract full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brain Health Support, from the product label.

Amandean

See all Amandean products
Name
Amandean
Web Address
AMANDEAN.com
Pharmacist Counseling Corner

Brain Health Support by Amandean: Common Questions

Does Brain Health Support by Amandean interact with any medications?
Yes. Based on its ingredients, Brain Health Support has a known interaction with 508 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brain Health Support contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is alpha-GPC safe to take long-term?
Alpha-GPC is generally well tolerated, but long-term safety isn't fully established. One concern: oral use for 2 months or longer has been rarely associated with an elevated stroke risk compared with non-users or shorter-term use. Talk with your pharmacist about how long you plan to use it.
Can I take this if I'm pregnant?
It depends on the ingredient. Magnesium is likely safe at normal dietary levels and possibly safe as a supplement under your doctor's guidance during pregnancy. However, alpha-GPC and lion's mane mushroom don't have enough safety data — the safety information advises against them in pregnancy. Talk with your doctor or pharmacist before using this product if you're pregnant.
What does lion's mane mushroom do in this product?
Lion's mane is included for potential brain health support, but the evidence isn't established yet for cognitive function, Alzheimer disease, anxiety, athletic performance, or cancer. It's a medicinal fungus used traditionally for the brain, but it hasn't been proven effective for these conditions in reliable studies.
Will magnesium in this product cause diarrhea?
Magnesium can cause diarrhea, nausea, vomiting, and gastrointestinal irritation, especially at higher doses — though many people tolerate it well. If you're sensitive to magnesium's effects, start with a lower dose or talk with your pharmacist about managing side effects.
Does this product actually improve memory or cognitive function?
The evidence is limited. Alpha-GPC is possibly effective for Alzheimer disease, but the data doesn't support it for general memory or cognitive function. Lion's mane and magnesium haven't been proven effective for those purposes. If cognitive support is your goal, the science behind this product isn't strong yet.
Can I take this while breastfeeding?
Magnesium in normal dietary amounts is fine, but check with your doctor before using supplements while breastfeeding. Alpha-GPC and lion's mane mushroom don't have enough safety data — the information advises against them while breastfeeding. Talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brain Health Support label
Go deeper

The Full Monographs Behind Brain Health Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Brain Health Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 92 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnesium 82 references
  1. Rodin SM, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
  2. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  3. Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80. PubMed
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257-63. PubMed
  6. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  7. Birrer RB, Shallash AJ, Totten V. Hypermagnesemia-induced fatality following epsom salt gargles. J Emerg Med 2002;22:185-8. PubMed
  8. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  9. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  10. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..
  11. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. Cephalalgia 1996;16:436-40.. PubMed
  12. Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003;43:601-10.. PubMed
  13. Sompolinsky D, Samra Z. Influence of magnesium and manganese on some biological and physical properties of tetracycline. J Bacteriol 1972;110:468-76.. PubMed
  14. Jeyabalan A, Caritis SN. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002;45:99-113. PubMed
  15. Mittendorf R, Dambrosia J, Pryde PG, et al. Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 2002;186:1111-8.. PubMed
  16. Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998;92:883-9.. DOI
  17. Crowther CA, Hiller JE, Doyle LW. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2002;4:CD001060. . PubMed
  18. Davey MJ, Teubner D. A randomized controlled trial of magnesium sulfate, in addition to usual care, for rate control in atrial fibrillation. Ann Emerg Med 2005;45:347-53.. PubMed
  19. L'Hommedieu CS, Nicholas D, Armes DA, et al. Potentiation of magnesium sulfate--induced neuromuscular weakness by gentamicin, tobramycin, and amikacin. J Pediatr 1983;102:629-31..
  20. Dunn CJ, Goa KL. Risedronate: a review of its pharmacological properties and clinical use in resorptive bone disease. Drugs 2001;61:685-712..
  21. Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr 2012;66:411-8. PubMed
  22. Koontz SL, Friedman SA, Schwartz ML. Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. Am J Obstet Gynecol. 2004;190(6):1773-6. PubMed
  23. Snyder SW, Cardwell MS. Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol. 1989;161(1):35-6. PubMed
  24. Waisman GD, Mayorga LM, Cámera MI, et al. Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia? Am J Obstet Gynecol. 1988;159(2):308-9. PubMed
  25. Brown DD, Juhl RP. Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med. 1976;295(19):1034-7. PubMed
  26. Allen MD, Greenblatt DJ, Harmatz JS, et al. Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules. J Clin Pharmacol. 1981;21(1):26-30. PubMed
  27. Ravn HB, Vissinger H, Kristensen SD, et al. Magnesium inhibits platelet activity--an in vitro study. Thromb Haemost. 1996;76(1):88-93. DOI
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Alpha-gpc 4 references
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See these in context on the Alpha-gpc monograph →

Lion's Mane Mushroom 6 references
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See these in context on the Lion's Mane Mushroom monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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