Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Vegan D3 125 mcg + K2 100 mcg Ingredients & Drug Interactions

by Amandean

Vegan D3 125 mcg + K2 100 mcg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vegan D3 125 mcg + K2 100 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vegan D3 125 mcg + K2 100 mcg is a dietary supplement by Amandean with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin D, Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vegan D3 125 mcg + K2 100 mcg by Amandean

Ask about any prescription or over-the-counter medication and we check it for interactions with Vegan D3 125 mcg + K2 100 mcg by Amandean — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vegan D3 125 mcg + K2 100 mcg by Amandean

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: vitamin D (125 mcg, or 5,000 IU) and vitamin K2 (100 mcg). Vitamin D supports bone and mineral health and helps your body absorb calcium, while vitamin K2 plays a role in bone metabolism and blood clotting.

The capsules also contain inactive ingredients — coconut oil, MCT oil, modified tapioca starch, vegetable glycerin, purified water, and natural tocopherols — which help deliver and preserve the active nutrients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cardiovascular health, bone strength, immune support, muscle.
  • We looked for evidence on: Cardiovascular disease (CVD), Fractures, Osteoporosis, Muscle strength, Bone density, Vascular health.
  • The strongest evidence on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis (Natural Medicines).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Cardiovascular disease (CVD), Fractures.

Vitamin D is established as effective for treating rickets, osteomalacia (soft bones), renal bone disease, hypoparathyroidism, and familial hypophosphatemia. Vitamin K2 is effective for vitamin K-dependent clotting factor deficiency and hemorrhagic disease, and is possibly effective for osteoporosis — though the evidence for that use isn't as strong.

If you're taking this for bone or mineral support, talk with your doctor about whether the dose and combination match your needs.

The evidence, ingredient by ingredient Vitamin D Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, though very high doses over time can cause toxicity with symptoms of high blood calcium, bone loss, and eye or kidney problems. Vitamin K2 taken by mouth is generally well tolerated; mild gastrointestinal side effects like nausea, stomach upset, and diarrhea are the most common concern.

Vitamin K2 is rated likely safe in pregnancy and lactation at normal dietary amounts, but the product's dose and your personal situation should be discussed with your doctor. Vitamin D has limited pregnancy and lactation data on file — talk with your doctor or pharmacist for personalized guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin D Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Most important: blood thinners, especially warfarin — vitamin K2 reduces their effect (Major severity). Also double-check thiazide diuretics, calcium-channel blockers (verapamil, diltiazem), digoxin, statin drugs like atorvastatin, and any vitamin D skin treatments, since the vitamin D dose here is above the standard upper limit and carries Moderate-level concerns.

If you're taking aluminum-containing antacids or have kidney disease, flag those too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take a blood thinner like warfarin, or any heart, bone, or kidney medication, run this product through the interaction checker below before you start — the vitamin D dose here is fairly high, and the vitamin K2 directly opposes blood thinners. Generally well-tolerated for most people at recommended use, but check with your pharmacist if you're on multiple medications or have kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vegan D3 125 mcg + K2 100 mcg, straight from the product label.

Brand Amandean
Barcode (UPC) X002RX9AAZ
Net contents 120 Vegan Softgel(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276040
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vegan D3 125 mcg + K2 100 mcg by Amandean, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Liquid Veggie Softgel
Maximum serving Sizes:
1 Liquid Veggie Softgel
Servings per container
120
UPC/BARCODE
X002RX9AAZ
IngredientAmount% DV
Vitamin D120 mcg625%
Vitamin K2100 mcg83%

Other ingredients: Coconut Oil, MCT Oil, non-GMO modified Tapioca Starch, non-GMO Vegetable Glycerin, Water, Purified, Tocopherols, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan D3+K2

Formulated with organic coconut oil in a carrageenan-free softgel for increased bioavailability.

100% vegan

Non-GMO

Sustainably sourced cGMP certified

Carrageenan free

Heart Bones Immunity Muscle

120 vegan softgels

Awesomely American

VegD3 is a plant-based, vegan vitamin D3 exclusively distributed by AIDP, Inc.

Formula

Vegan D3+K2 Vitamins D3 & K2, two essential nutrients that promote cardiovascular health, bone strength, immune support, & muscle. VegD3 is sustainably-sourced from lab-grown algal oil in the UK, not from lichen or lanolin sourced in China. K2Vital contains 99.7% all-trans MK-7, known as the purest bioactive form available. Formulated with organic coconut oil in a carrageenan-free softgel for increased bioavailability.

This product is intended for individuals with sub-optimal levels of vitamin D who don't get the recommended daily intake from their diet.

Formulated with organic coconut oil

125 mcg vitamin D3 5000 IU 100 mcg vitamin K2 as K2VITAL

VegD3 is a plant-based, vegan vitamin D3 exclusively distributed by AIDP, Inc.

Suggested/Recommended/Usage/Directions

Directions for use: Take 1 softgel daily, or as directed by a health professional.

Precautions

Do not exceed recommended daily dose.

Cautions: Use as directed.

If you are pregnant or nursing, under the age of 18, taking a blood-thinning medication, or have a known medical condition, you should consult a healthcare practitioner prior to use.

If you are pregnant or nursing, under the age of 18, taking a blood-thinning medication, or have a known medical condition, you should consult a healthcare practitioner prior to use. Keep out of the reach of children.

Allergen warning: Contains tree nuts (coconut).

General Statements

Certified plastic neutral product

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Featuring: VegD3 VegD3 is a trademark of Avlaan, Inc. VegD3 is a plant-based, vegan vitamin D3 exclusively distributed by AIDP, Inc.

K2VITAL K2VITAL is a registered trademark of Kappa Bioscience.

Storage

Storage: Store at room temperature, in a dry place. Protect product from excessive heat, freezing, humidity, and light.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vegan D3 125 mcg + K2 100 mcg by Amandean label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vegan D3 125 mcg + K2 100 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vegan D3 125 mcg + K2 100 mcg by Amandean

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Liquid Veggie Softgel Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
120 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Vitamin K2

Interacts with
2 drugs
100 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Coconut Oil, MCT Oil, Non-GMO modified Tapioca Starch, Non-GMO Vegetable Glycerin, Water, Purified, Tocopherols, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vegan D3 125 mcg + K2 100 mcg by Amandean Drug Interactions

Want to check YOUR meds against Vegan D3 125 mcg + K2 100 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
715Drugs
2 Major 80 Moderate 633 Minor

Ingredients driving the most interactions

Vitamin D 715
Vitamin K2 2

Individual Drug Interactions

The ingredients in Vegan D3 125 mcg + K2 100 mcg interact with 715 drugs. Click any drug to see the details.

2 of the 2 ingredients in Vegan D3 125 mcg + K2 100 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vegan D3 125 mcg + K2 100 mcg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vegan D3 125 mcg + K2 100 mcg, from the product label.

Amandean

See all Amandean products
Name
Amadean, LLC
Street Address
774 Mays Blvd. #10-427
City
Incline Village
State
NV
ZipCode
89451
Phone Number
+1 415-287-3377
Web Address
AMANDEAN.COM
Pharmacist Counseling Corner

Vegan D3 125 mcg + K2 100 mcg by Amandean: Common Questions

Does Vegan D3 125 mcg + K2 100 mcg by Amandean interact with any medications?
Yes. Based on its ingredients, Vegan D3 125 mcg + K2 100 mcg has a known interaction with 715 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vegan D3 125 mcg + K2 100 mcg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No — vitamin K2 directly counteracts warfarin's blood-thinning effect. Do not start this product without talking to your doctor or pharmacist first. They may need to adjust your warfarin dose or choose a different supplement.
What's the dose of vitamin D in this, and is it safe?
Each softgel contains 125 mcg, which is 5,000 IU — higher than the upper daily limit of 4,000 IU recommended for most adults. Vitamin D is well tolerated at recommended doses, but very high doses over time can cause toxicity. Talk with your doctor about whether this dose is right for you.
What are the side effects?
At normal doses, both vitamin D and K2 are generally well tolerated. Vitamin K2 may occasionally cause mild stomach upset, nausea, or diarrhea. Vitamin D toxicity is rare at moderate doses but can occur with excessive intake over time, causing high blood calcium, bone loss, and eye problems.
Is this safe to take if I'm pregnant or breastfeeding?
Vitamin K2 is rated likely safe during pregnancy and lactation at dietary amounts. Vitamin D has limited safety data on file for these periods. Talk with your doctor or pharmacist about whether this product and dose are appropriate for your situation.
What's the difference between vitamin D and vitamin K2?
Vitamin D helps your body absorb calcium and supports bone and mineral health. Vitamin K2 is involved in bone metabolism and blood clotting. Together they support bone strength, but they work through different mechanisms.
Why are there so many inactive ingredients?
The coconut oil, MCT oil, glycerin, and other inactive ingredients are there to help dissolve and deliver the vitamin D and K2 (which are fat-soluble), preserve freshness, and form the softgel capsule. They're standard in supplement manufacturing and aren't fillers in the sense of being useless — they're necessary for the product to work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vegan D3 125 mcg + K2 100 mcg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vegan D3 125 mcg + K2 100 mcg label
Go deeper

The Full Monographs Behind Vegan D3 125 mcg + K2 100 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vegan D3 125 mcg + K2 100 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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