Brain Support + Ingredients & Drug Interactions
by OmneDiem
What is this page for?
First and foremost: checking Brain Support + against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Brain Support + is a dietary supplement by OmneDiem with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Brain Support + by OmneDiem
Ask about any prescription or over-the-counter medication and we check it for interactions with Brain Support + by OmneDiem — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Brain Support + by OmneDiem
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Brain Support + contains two active ingredients. Vitamin B12 is an essential nutrient involved in nerve function and energy production — your body can't make it, so you need it from food or supplements.
Cerenx is a branded form of citicoline, a compound that plays a role in brain cell structure and may support cognitive function. The product also contains inactive ingredients like hypromellose, microcrystalline cellulose, silicon dioxide, and magnesium stearate, which are common capsule fillers and binders.
Does it work?
Moderate evidence
Vitamin B12 is effective for treating B12 deficiency and a rare inherited disorder called Imerslund-Grasbeck disease, and it's likely effective for cyanide poisoning. It's possibly effective for canker sores and a nerve pain condition called postherpetic neuralgia.
Citicoline (Cerenx) is possibly effective for age-related cognitive decline and glaucoma. For Alzheimer disease and traumatic brain injury, the evidence isn't established yet in our data.
For stroke, current evidence suggests it may not be effective.
How safe is it?
Well-documented data
Vitamin B12 is generally very well tolerated — your body clears excess through urine, so there's no established upper limit. The most common side effect with injections is irritation at the injection site.
Allergic reactions like rash or itching are rare but possible, especially in people with a cobalt allergy. B12 is needed during pregnancy and breastfeeding and is considered safe at normal recommended amounts — follow your provider's guidance.
Citicoline has been generally well tolerated in studies, though long-term safety isn't fully established. Common side effects may include abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, insomnia, nausea, and rash — most appear in a small number of trial participants.
The safety data advises against using this ingredient during pregnancy or breastfeeding because there isn't enough information to know it's safe.
Meds to double-check
Minor interactions only
If you take metformin (a diabetes medication), that's your main flag — B12 in this product may lower your metformin-related B12 levels. Check your full medication list with the search tool on this page to be thorough.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
This product may be worth considering if you have low B12 levels or want brain support and aren't pregnant or breastfeeding. If you take metformin for diabetes, check with your pharmacist first — this product could affect how well it works for B12 absorption.
Let your pharmacist know about any other medications or supplements you're on before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Brain Support +, straight from the product label.
| Brand | OmneDiem |
|---|---|
| Barcode (UPC) | 850023777553 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 334383 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Brain Support + by OmneDiem, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B12 | 1000 mcg | 41666% |
| Cerenx | 500 mg | -- |
Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take 1 to 2 capsules daily. For best results, take early in the day after eating.
Formula
OmneDiem Brain Support Plus features Cerenx brand Citicoline, a natural source of choline that promotes healthy brain structures and functions.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Manufactured in a GMP compliant facility.
This product is suitable for vegetarians/vegans.
Vegetarian caps
Dietary support for brain health, mood & mental function
Does not contain: wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
DRcaps
Brand IP Statement(s)
Cerenx is a registered trademark of OmneDiem MecobalActive is a registered trademark of Health Tech Bio Actives, S.L.U.
DRcaps is a trademark of Lonza or its affiliates.
General Statements
This package is completely recyclable
FDA Statement of Identity
Dietary Supplement
Storage
Storage: Keep closed in a cool, dry place out of reach of children.
Precautions
Storage: Keep closed in a cool, dry place out of reach of children.
Do not use if tamper seal is damaged.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Brain Support + by OmneDiem label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Brain Support + by OmneDiem
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsCerenx
No knowninteractions
Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...
Cerenx monograph & interactionsOther (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Brain Support + by OmneDiem Drug Interactions
HelloPharmacist Interaction Report
Brain Support + by OmneDiem contains two active ingredients, and one of them does interact with medications.
Vitamin B12 can lower levels in your blood if you're taking metformin (Glucophage), a common diabetes medication. Metformin interferes with how your digestive system absorbs B12, and over time this may lead to a deficiency — so if you take metformin, mention this product to your pharmacist or doctor before starting it.
Read the full breakdown — every affected drug type, severity by severity
Cerenx (citicoline), the second ingredient, shows no interactions documented in our data with the medications we've checked.
Altogether, these interactions span 19 individual medications. That count includes metformin plus related compounds and drug classes we hold interaction data for.
Run your exact medications through the checker on this page to be sure.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Brain Support +?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Brain Support + interact with 20 drugs. Click any drug to see the details.
1 of the 2 ingredients in Brain Support + interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Alogliptin, Metformin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Canagliflozin, Metformin Hydrochloride interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Metformin Hydrochloride interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Ertugliflozin, Metformin Hydrochloride interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Glyburide, Metformin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Linagliptin, Metformin Hydrochloride interactionMetforminGlucophage, Metformin
How Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Sitagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Saxagliptin, Metformin Xr interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Sitagliptin, Metformin interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with Brain Support + — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Pioglitazone, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Brain Support + with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
Brand information
Manufacturer and brand details for Brain Support +, from the product label.
OmneDiem
See all OmneDiem products- Name
- OmneDiem
- Street Address
- 221 Dino Drive Suite A
- City
- Ann Arbor
- State
- MI
- ZipCode
- 48103
Brain Support + by OmneDiem: Common Questions
Does Brain Support + by OmneDiem interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What is citicoline (Cerenx) and why is it in here?
Does this product actually work for memory or brain fog?
What side effects should I watch for?
Is there a limit to how much B12 I can take safely?
I take metformin for diabetes. Is this product okay for me?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Brain Support + is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Brain Support +’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin B12
Interacts with 20 drugsVitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...
Read the full Vitamin B12 monograph → Herb & supplement monographCiticoline
Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...
Read the full Citicoline monograph →Sources & How We Checked
Brain Support +'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B12 30 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
- Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
- Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
- Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
- Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
- Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
- Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
- Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
- Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
- Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
- Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
- Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
- Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
- Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
- Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
- Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
- Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
- Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
- Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
- Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
- Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
- Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
- Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
- Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
- Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
- Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
- Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed
Citicoline 11 references
- Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
- Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
- Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
- Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
- Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
- Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
- Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
- Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
- Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
- Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
- Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC